Mus musculus L. (mouse) [MMU]

FULL NAME: Cullin-4A


DESCRIPTION:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9 (By similarity).

STRUCTURE SIMILARITY:
Belongs to the cullin family.


POST-TRANSLATIONAL MODIFICATION:
Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated by murine cytomegalovirus M48 leading to a S-phase-like environment that is required for efficient replication of the viral genome.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MADEGPRKGS VSALMGRTNG LTKPAALAGG PAKPGGTGGS RKLVIKNFRD RPRLPDNYTQ
        70         80         90        100        110        120
DTWRKLHEAV KAIQSSTSIR YNLEELYQAV ENLCSHKVSP TLYKQLRQVC EDHVQAQILP
       130        140        150        160        170        180
FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY VLQNSMLPSI WDMGLELFRN
       190        200        210        220        230        240
HIISDRMVQS KTIDGILLLI GRERSGEAVD RSLLRSLLSM LSDLQVYKDS FELKFLEETN
       250        260        270        280        290        300
CLYAAEGQRL MQDREVPEYL NHVSKRLEEE ADRVITYLDH STQKPLIACV EKQLLGEHLT
       310        320        330        340        350        360
AILQKGLEHL LDENRVPDLT QMYQLFSRVK GGQHALLQHW SEYIKTFGTT IVINPEKDKD
       370        380        390        400        410        420
MVQDLLDFKD KVDHVVEVCF QRNERFINLM KESFETFINK RPNKPAELIA KHVDSKLRAG
       430        440        450        460        470        480
NKEATDEELE RILDKIMILF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK
       490        500        510        520        530        540
HECGAAFTSK LEGMFKDMEL SKDIMVHFKQ HMQNQSAPGP IDLTVNILTM GYWPTYTPME
       550        560        570        580        590        600
VHLPPEMVRL QEVFKTFYLG KHSGRKLQWQ TTLGHAVLKA DFKEGKKEFQ VSLFQTLVLL
       610        620        630        640        650        660
MFNEGDGFSF EEIKMATGIE DSELRRTLQS LACGKARVLI KSPKGKEVED GDKFIFNADF
       670        680        690        700        710        720
KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAI VRIMKMRKTL GHNLLVSELY
       730        740        750
NQLKFPVKPG DLKKRIESLI DRDYMERDKD SPNQYHYVA  

Encoded by Cul4a gene

FULL NAME: cullin 4A


OTHER NAME(S):
2810470J21Rik
AW495282
MGC36573


Nucleic acid sequence

        10         20         30         40         50         60
atggcggacg agggccctcg gaagggcagc gtctcggctc tcatgggccg caccaacggc
        70         80         90        100        110        120
ctcaccaagc ccgcggcgtt ggccggtggc cccgccaagc cggggggcac gggaggctcc
       130        140        150        160        170        180
aggaagctgg tcatcaagaa cttccgagac aggccgcggc tgcctgacaa ctacactcag
       190        200        210        220        230        240
gacacgtggc ggaagcttca cgaagcggtc aaggccatcc agagcagcac atccatcagg
       250        260        270        280        290        300
tacaacctgg aggagctgta ccaggctgtt gaaaatcttt gttctcacaa agtctcccca
       310        320        330        340        350        360
acgctctaca agcagctgcg ccaggtctgt gaagaccatg tccaggccca gatcctccca
       370        380        390        400        410        420
ttcagagaag actcactaga cagcgtttta tttctaaaga agattaacac atgctggcaa
       430        440        450        460        470        480
gatcactgca gacaaatgat catgatcaga agcatcttcc tgtttctgga tcgaacctac
       490        500        510        520        530        540
gtcctccaga attccatgct gccttctatc tgggacatgg gcctagagct gtttaggaac
       550        560        570        580        590        600
cacatcatca gcgacaggat ggtgcagagt aagaccattg atgggatcct gctgctgatt
       610        620        630        640        650        660
gggcgtgaac gaagtggaga ggctgtggac aggagtctgc ttcggagttt gctaagcatg
       670        680        690        700        710        720
ctctcagatc tccaggtgta caaagactca tttgagctga agttcttgga agagactaac
       730        740        750        760        770        780
tgtctatacg ctgctgaagg ccagaggctg atgcaggaca gggaggttcc agaatacctt
       790        800        810        820        830        840
aaccatgtga gcaaacgtct agaagaggaa gcagaccgag tgatcaccta cttagaccac
       850        860        870        880        890        900
agcacacaaa aaccgttgat tgcctgtgtg gagaaacagc tgttaggaga acatttgaca
       910        920        930        940        950        960
gcaattctac agaaaggcct agagcacctg ctggatgaga acagggtgcc cgacctcacc
       970        980        990       1000       1010       1020
cagatgtacc agctcttcag ccgggtgaaa ggagggcagc atgcgctgct gcagcactgg
      1030       1040       1050       1060       1070       1080
agcgagtaca tcaagacctt tggaacaacc attgtcatca atcctgagaa agacaaagac
      1090       1100       1110       1120       1130       1140
atggtccaag acctgctgga ctttaaggac aaagtggacc acgtggtgga ggtgtgcttc
      1150       1160       1170       1180       1190       1200
cagaggaacg agcgcttcat caacctgatg aaggagtcct tcgagacgtt catcaacaag
      1210       1220       1230       1240       1250       1260
agaccaaaca agcctgcaga gctcattgcc aagcacgtgg actcaaagtt acgggccggc
      1270       1280       1290       1300       1310       1320
aacaaagaag ccacagatga ggaactggag aggatcctgg acaagatcat gattctcttc
      1330       1340       1350       1360       1370       1380
cgtttcatcc atggtaaaga tgtctttgaa gcgttttata agaaagactt agcaaaaagg
      1390       1400       1410       1420       1430       1440
ctgctggtgg ggaagagcgc gtcggtggac gcggagaagt ccatgctgtc gaagctcaag
      1450       1460       1470       1480       1490       1500
cacgagtgcg gagctgcgtt taccagcaaa ctggagggca tgttcaagga catggagctc
      1510       1520       1530       1540       1550       1560
tccaaagaca tcatggttca cttcaagcag catatgcaga accagagtgc gccaggcccc
      1570       1580       1590       1600       1610       1620
attgacctca cggtgaacat actcaccatg ggctactggc ccacgtacac acccatggaa
      1630       1640       1650       1660       1670       1680
gtgcacctcc ctccagagat ggtcagactt caggaagtat tcaagacgtt ctacctgggc
      1690       1700       1710       1720       1730       1740
aagcacagtg ggcggaagct gcaatggcag acaacgctgg gacacgccgt gctgaaggcg
      1750       1760       1770       1780       1790       1800
gactttaagg aggggaagaa ggagttccag gtatccctct tccagacgct ggtgctgctc
      1810       1820       1830       1840       1850       1860
atgttcaacg aaggggatgg atttagcttt gaagaaataa aaatggccac tggcatagag
      1870       1880       1890       1900       1910       1920
gacagtgagt tgcgaagaac actacagtct ctggcctgtg gtaaagcacg ggtcctaatt
      1930       1940       1950       1960       1970       1980
aaaagtccca aaggaaagga ggtggaagat ggagataagt tcatcttcaa tgcagacttc
      1990       2000       2010       2020       2030       2040
aaacacaagt tgttcagaat aaagatcaat caaatccaga tgaaggagac cgttgaagaa
      2050       2060       2070       2080       2090       2100
caggttagca ctacagagag agtattccag gatagacagt accagatcga cgctgctata
      2110       2120       2130       2140       2150       2160
gtcagaataa tgaaaatgag gaagacactt ggtcataatc ttctagtttc tgaattatac
      2170       2180       2190       2200       2210       2220
aatcagctga aatttccagt gaagcctgga gatttgaaaa aaaggattga gtcacttata
      2230       2240       2250       2260       2270       2280
gacagagact atatggaacg agacaaagac agtccaaatc agtaccacta cgtggcatga

Last modification date: Oct. 2, 2011