Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA polymerase III subunit delta'


DESCRIPTION:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MRWYPWLRPD FEKLVASYQA GRGHHALLIQ ALPGMGDDAL IYALSRYLLC QQPQGHKSCG
        70         80         90        100        110        120
HCRGCQLMQA GTHPDYYTLA PEKGKNTLGV DAVREVTEKL NEHARLGGAK VVWVTDAALL
       130        140        150        160        170        180
TDAAANALLK TLEEPPAETW FFLATREPER LLATLRSRCR LHYLAPPPEQ YAVTWLSREV
       190        200        210        220        230        240
TMSQDALLAA LRLSAGSPGA ALALFQGDNW QARETLCQAL AYSVPSGDWY SLLAALNHEQ
       250        260        270        280        290        300
APARLHWLAT LLMDALKRHH GAAQVTNVDV PGLVAELANH LSPSRLQAIL GDVCHIREQL
       310        320        330
MSVTGINREL LITDLLLRIE HYLQPGVVLP VPHL  

Encoded by holB gene


OTHER NAME(S):
ECK1085
JW1085


DESCRIPTION:
The crystal structure of delta' has been determined. [More information is available at EcoCyc: EG11500].


Nucleic acid sequence

        10         20         30         40         50         60
atgagatggt atccatggtt acgacctgat ttcgaaaaac tggtagccag ctatcaggcc
        70         80         90        100        110        120
ggaagaggtc accatgcgct actcattcag gcgttaccgg gcatgggcga tgatgcttta
       130        140        150        160        170        180
atctacgccc tgagccgtta tttactctgc caacaaccgc agggccacaa aagttgcggt
       190        200        210        220        230        240
cactgtcgtg gatgtcagtt gatgcaggct ggcacgcatc ccgattacta caccctggct
       250        260        270        280        290        300
cccgaaaaag gaaaaaatac gctgggcgtt gatgcggtac gtgaggtcac cgaaaagctg
       310        320        330        340        350        360
aatgagcacg cacgcttagg tggtgcgaaa gtcgtttggg taaccgatgc tgccttacta
       370        380        390        400        410        420
accgacgccg cggctaacgc attgctgaaa acgcttgaag agccaccagc agaaacttgg
       430        440        450        460        470        480
tttttcctgg ctacccgcga gcctgaacgt ttactggcaa cattacgtag tcgttgtcgg
       490        500        510        520        530        540
ttacattacc ttgcgccgcc gccggaacag tacgccgtga cctggctttc acgcgaagtg
       550        560        570        580        590        600
acaatgtcac aggatgcatt acttgccgca ttgcgcttaa gcgccggttc gcctggcgcg
       610        620        630        640        650        660
gcactggcgt tgtttcaggg agataactgg caggctcgtg aaacattgtg tcaggcgttg
       670        680        690        700        710        720
gcatatagcg tgccatcggg cgactggtat tcgctgctag cggcccttaa tcatgaacaa
       730        740        750        760        770        780
gctccggcgc gtttacactg gctggcaacg ttgctgatgg atgcgctaaa acgccatcat
       790        800        810        820        830        840
ggtgctgcgc aggtgaccaa tgttgatgtg ccgggcctgg tcgccgaact ggcaaaccat
       850        860        870        880        890        900
ctttctccct cgcgcctgca ggctatactg ggggatgttt gccacattcg tgaacagtta
       910        920        930        940        950        960
atgtctgtta caggcatcaa ccgcgagctt ctcatcaccg atcttttact gcgtattgag
       970        980        990       1000
cattacctgc aaccgggcgt tgtgctaccg gttcctcatc tttaa 

Last modification date: Oct. 2, 2011