Mus musculus L. (mouse) [MMU]

FULL NAME: Cullin-4B


DESCRIPTION:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity).

STRUCTURE SIMILARITY:
Belongs to the cullin family.


POST-TRANSLATIONAL MODIFICATION:
Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSRSTRSKER RENDTDSEDN SSETSNQERR RCRQGPPRPP YPPLLPPVFP PPTPPPQVRR
        70         80         90        100        110        120
TRGLQDLGAM KSVCPGTSGF SSPNPSAASA AAQEVRSATD GNTSTTPPTS AKKRKLNSSS
       130        140        150        160        170        180
SSSNSSNERE DFDSTSSSST PPQPRDSASP STSSFCLGVP VATSSHVPIQ KKLRFEDTLE
       190        200        210        220        230        240
FVGIDTKMAE ESSSSSSSSS PTAATSQQQQ QQQLKTKSIL ISSVASVHHA NGLAKSSTAV
       250        260        270        280        290        300
SSFANSKPGS AKKLVIKNFK DKPKLPENYT DETWQKLKEA VEAIQNSTSI KYNLEELYQA
       310        320        330        340        350        360
VENLCSHKIS ANLYKQLRQI CEDHIKAQIH QFREDSLDSV LFLKKIDRCW QNHCRQMIMI
       370        380        390        400        410        420
RSIFLFLDRT YVLQNSMLPS IWDMGLELFR AHIISDQKVQ TKTIDGILLL IERERNGEAI
       430        440        450        460        470        480
DRSLLRSLLS MLSDLQIYQD SFEQQFLQET NRLYAAEGQK LMQEREVPEY LHHVNKRLEE
       490        500        510        520        530        540
EADRLITYLD QTTQKSLIAS VEKQLLGEHL TAILQKGLNS LLDENRIQDL SLLYQLFSRV
       550        560        570        580        590        600
RGGVQVLLQQ WIEYIKAFGS TIVINPEKDK TMVQELLDFK DKVDHIIDTC FLKNEKFINA
       610        620        630        640        650        660
MKEAFETFIN KRPNKPAELI AKYVDSKLRA GNKEATDEEL EKMLDKIMII FRFIYGKDVF
       670        680        690        700        710        720
EAFYKKDLAK RLLVGKSASV DAEKSMLSKL KHECGAAFTS KLEGMFKDME LSKDIMIQFK
       730        740        750        760        770        780
QYMQNQNVPG NIELTVNILT MGYWPTYVPM EVHLPPEMVK LQEIFKTFYL GKHSGRKLQW
       790        800        810        820        830        840
QSTLGHCVLK AEFKEGKKEL QVSLFQTMVL LMFNEGEEFS LEEIKHATGI EDGELRRTLQ
       850        860        870        880        890        900
SLACGKARVL AKNPKGKDIE DGDKFICNDD FKHKLFRIKI NQIQMKETVE EQASTTERVF
       910        920        930        940        950        960
QDRQYQIDAA IVRIMKMRKT LSHNLLVSEV YNQLKFPVKP ADLKKRIESL IDRDYMERDK
       970
ENPNQYNYIA     

Encoded by Cul4b gene

FULL NAME: cullin 4B


OTHER NAME(S):
2700050M05Rik
AA409770
KIAA0695
mKIAA0695


Nucleic acid sequence

        10         20         30         40         50         60
atgtcacgtt caactaggtc taaagaaaga agagagaatg acaccgactc agaagataac
        70         80         90        100        110        120
agttcggaaa cctccaatca agagcgccga aggtgtcgcc aaggtccgcc ccgccctccc
       130        140        150        160        170        180
tatccacctc ttttaccccc cgtgttccct cccccaaccc ccccacctca agtccggcgg
       190        200        210        220        230        240
acccgggggc ttcaggatct gggagctatg aaaagtgtct gcccaggcac ttccggtttt
       250        260        270        280        290        300
tcttccccca atccctctgc tgcttctgct gctgctcagg aggtcagatc tgccactgat
       310        320        330        340        350        360
ggtaatacca gcaccactcc gcccacctct gccaagaaga gaaagttaaa cagcagcagt
       370        380        390        400        410        420
agcagcagta acagtagtaa cgagagagaa gactttgatt ccacctcttc ctcttccacc
       430        440        450        460        470        480
cctccacaac ccagagattc ggcgtcccct tcaacctcgt ccttctgcct tggggttcca
       490        500        510        520        530        540
gtggccactt ccagccacgt acctatacag aagaagctgc ggtttgaaga caccctggag
       550        560        570        580        590        600
tttgtaggga ttgatacgaa aatggctgag gaatcttcct cctcatcttc ctcatcttcg
       610        620        630        640        650        660
ccaactgctg caacctcaca gcagcagcag cagcaacaac ttaaaactaa gagtatatta
       670        680        690        700        710        720
atttcttctg tggcttcagt gcaccatgca aacggcctgg ctaaatcttc taccgcggtc
       730        740        750        760        770        780
tctagctttg ctaacagcaa gcccggctca gctaagaagt tagtgatcaa gaactttaaa
       790        800        810        820        830        840
gataagccta aattaccaga aaactatacg gatgagacat ggcaaaagct aaaagaagca
       850        860        870        880        890        900
gtggaagcca ttcagaatag tacttcaatt aagtacaatt tagaagaact ctaccaggct
       910        920        930        940        950        960
gtagaaaatc tttgttctca taagatttct gcaaatttgt ataagcagct gaggcagata
       970        980        990       1000       1010       1020
tgtgaagatc acatcaaagc acagattcat cagttcagag aggattcatt ggatagtgtt
      1030       1040       1050       1060       1070       1080
ctttttctca aaaagatcga tagatgctgg caaaaccact gtaggcaaat gataatgatc
      1090       1100       1110       1120       1130       1140
aggagcattt ttttgtttct ggatagaact tatgttcttc agaattcaat gctaccctcc
      1150       1160       1170       1180       1190       1200
atttgggaca tgggattaga gttatttagg gctcatatta taagtgatca aaaagtacag
      1210       1220       1230       1240       1250       1260
acaaaaacga ttgatggcat ccttctcttg attgagagag agcggaatgg tgaagcaatt
      1270       1280       1290       1300       1310       1320
gatagaagtt tacttcgaag ccttttaagt atgctgtctg atttgcaaat ttaccaagat
      1330       1340       1350       1360       1370       1380
tcttttgaac agcaattttt gcaagaaact aatcggcttt acgcagccga aggtcagaag
      1390       1400       1410       1420       1430       1440
ttaatgcaag aaagagaggt tcctgagtat cttcatcatg ttaataaacg cctagaagaa
      1450       1460       1470       1480       1490       1500
gaagctgaca gacttattac ttacttagat cagaccaccc agaagtcact aattgcttct
      1510       1520       1530       1540       1550       1560
gttgaaaaac aacttctagg tgaacactta acggcaattc ttcaaaaagg tttaaatagc
      1570       1580       1590       1600       1610       1620
ctccttgatg aaaaccgaat tcaagatttg tctctcctgt atcagctctt cagtagagtt
      1630       1640       1650       1660       1670       1680
cggggtggag ttcaggttct cttacagcag tggattgagt atatcaaggc ttttggaagt
      1690       1700       1710       1720       1730       1740
accattgtta ttaatcctga aaaagataaa actatggttc aagaattatt ggactttaaa
      1750       1760       1770       1780       1790       1800
gataaagttg accatataat tgatacctgc tttctgaaaa atgaaaaatt tatcaatgcc
      1810       1820       1830       1840       1850       1860
atgaaagaag cttttgaaac attcattaat aaaagaccaa ataagccagc tgaactgata
      1870       1880       1890       1900       1910       1920
gctaagtatg tggattcaaa acttcgtgca ggcaacaaag aagctacaga tgaagagctt
      1930       1940       1950       1960       1970       1980
gagaaaatgt tggataaaat aatgattata tttagattta tctatggtaa agatgttttt
      1990       2000       2010       2020       2030       2040
gaggccttct ataagaaaga tttagccaaa cgcctattag ttggcaagag tgcatcagta
      2050       2060       2070       2080       2090       2100
gatgctgaaa aatcaatgct gtccaaactg aaacacgaat gtggagccgc ttttaccagc
      2110       2120       2130       2140       2150       2160
aagcttgaag gaatgttcaa agacatggag ctttctaaag atatcatgat tcagtttaaa
      2170       2180       2190       2200       2210       2220
cagtatatgc agaaccagaa tgtacctggc aatattgaat taactgttaa tatcctgaca
      2230       2240       2250       2260       2270       2280
atgggttact ggccaacata tgtgcctatg gaagtccatt tgccgccaga gatggtaaag
      2290       2300       2310       2320       2330       2340
cttcaggaaa ttttcaagac attttactta ggcaagcaca gtggcaggaa actccagtgg
      2350       2360       2370       2380       2390       2400
cagtcaacct tgggacactg tgtgctaaaa gctgaattta aagagggcaa aaaagaactt
      2410       2420       2430       2440       2450       2460
caggtctctc tttttcaaac catggtgctg ctaatgttta atgaaggaga agaattcagt
      2470       2480       2490       2500       2510       2520
ttagaagaga tcaagcatgc tactgggata gaggatggag aattaagaag aacactgcag
      2530       2540       2550       2560       2570       2580
tcactagcct gtggcaaagc tagagttctg gctaaaaatc ctaagggcaa agatattgaa
      2590       2600       2610       2620       2630       2640
gatggtgaca aatttatttg taatgacgat ttcaaacaca aactattcag gataaagatc
      2650       2660       2670       2680       2690       2700
aatcaaatcc agatgaaaga aacggttgaa gaacaagcaa gcactacaga aagagtattt
      2710       2720       2730       2740       2750       2760
caagacagac agtaccaaat tgatgctgcg atcgttcgaa ttatgaagat gagaaaaaca
      2770       2780       2790       2800       2810       2820
cttagccaca atcttcttgt ttcagaagtc tacaatcagc taaaatttcc agttaaacct
      2830       2840       2850       2860       2870       2880
gctgatctta agaagagaat agaatccctc attgaccggg actacatgga aagagataaa
      2890       2900       2910
gaaaatccaa atcagtacaa ctatattgca tag  

Last modification date: Oct. 2, 2011