Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Probable Werner syndrome ATP-dependent helicase homolog 1


DESCRIPTION:
Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).

STRUCTURE SIMILARITY:
Contains 1 helicase C-terminal domain.
Contains 1 HRDC domain.
Contains 1 helicase ATP-binding domain.
Belongs to the helicase family. RecQ subfamily.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


Amino acids sequence

        10         20         30         40         50         60
MISDDDDLPS TRPGSVNEEL PETEPEDNDE LPETEPESDS DKPTVTSNKT ENQVADEDYD
        70         80         90        100        110        120
SFDDFVPSQT HTASKIPVKN KRAKKCTVES DSSSSDDSDQ GDDCEFIPAC DETQEVPKIK
       130        140        150        160        170        180
RGYTLRTRAS VKNKCDDSWD DGIDEEDVSK RSEDTLNDSF VDPEFMDSVL DNQLTIKGKK
       190        200        210        220        230        240
QFLDDGEFFT DRNVPQIDEA TKMKWASMTS PPQEALNALN EFFGHKGFRE KQWDVVRNVL
       250        260        270        280        290        300
GGKDQFVLMS TGYGKSVCYQ LPSLLLNSMT VVVSPLISLM NDQVTTLVSK GIDAVKLDGH
       310        320        330        340        350        360
STQIEWDQVA NNMHRIRFIY MSPEMVTSQK GLELLTSCRK HISLLAIDEA HCVSQWGHDF
       370        380        390        400        410        420
RNSYRHLAEI RNRSDLCNIP MIALTATATV RVRDDVIANL RLRKPLITTT SFDRKNLYIS
       430        440        450        460        470        480
VHSSKDMAED LGLFMKTDEV KGRHFGGPTI IYCQTKQMVD DVNCVLRRIG VRSAHYHAGL
       490        500        510        520        530        540
TKNQREKAHT DFMRDKITTI VATVAFGMGI DKPDVRNVIH YGCPNNIESY YQEIGRAGRD
       550        560        570        580        590        600
GSPSICRVFW APKDLNTIKF KLRNSQQKEE VVENLTMMLR QLELVLTTVG CRRYQLLKHF
       610        620        630        640        650        660
DPSYAKPPTM QADCCDRCTE MLNGNQDSSS SIVDVTTESK WLFQVINEMY NGKTGIGKPI
       670        680        690        700        710        720
EFLRGSSKED WRIKTTSQQK LFGIGKHIPD KWWKALAASL RIAGYLGEVR LMQMKFGSCI
       730        740        750        760        770        780
TLSELGERWL LTGKEMKIDA TPILLQGKKE KAAPSTVPGA SRSQSTKSST EIPTKILGAN
       790        800        810        820        830        840
KIREYEPANE NEQLMNLKKQ EVTGLPEKID QLRSRLDDIR VGIANMHEVA PFQIVSNTVL
       850        860        870        880        890        900
DCFANLRPTS ASNLEMIDGM SAQQKSRYGK RFVDCVVQFS KETGIATNVN ANDMIPPELI
       910        920        930        940        950        960
SKMQKVLSDA VRRVYTEHLI SRSTAKEVAT ARGISEGTVY SYLAMAVEKG LPLHLDKLNV
       970        980        990       1000       1010       1020
SRKNIAMALN AVRVHLGSNV AVLTPWVEAM GVVPDFNQLK LIRAILIYEY GLDTSENQEK
      1030       1040       1050
PDIQSMPSTS NPSTIKTVPS TPSSSLRAPP LKKFKL  

Encoded by wrn-1 gene

FULL NAME: human WRN (Werner's syndrome) related


Nucleic acid sequence

        10         20         30         40         50         60
atgataagtg atgatgacga tctaccatct actcgcccgg gatctgtgaa tgaggaatta
        70         80         90        100        110        120
ccagaaaccg aacccgaaga taatgatgag ttgcctgaaa cagaacctga aagcgattcc
       130        140        150        160        170        180
gataaaccta ccgtaacctc gaataaaaca gaaaaccaag ttgctgatga agattatgat
       190        200        210        220        230        240
tcattcgacg attttgtgcc cagtcaaaca cacacagcct ccaaaatacc tgtaaaaaat
       250        260        270        280        290        300
aaacgagcca aaaagtgcac tgtagaatct gattcatcat cttcggatga ttccgatcaa
       310        320        330        340        350        360
ggagatgatt gtgaatttat cccagcttgt gatgagacac aggaagttcc gaaaatcaaa
       370        380        390        400        410        420
agaggataca ctctgagaac tcgagcaagt gtaaagaaca aatgtgatga ttcatgggat
       430        440        450        460        470        480
gatggaatag acgaagaaga tgtctcaaaa agatcagaag acacgttaaa tgattcattt
       490        500        510        520        530        540
gttgatcctg aattcatgga ttctgttcta gataatcaat taacgatcaa aggcaaaaag
       550        560        570        580        590        600
caatttctcg atgatggaga gtttttcaca gaccggaatg ttcctcagat tgatgaagct
       610        620        630        640        650        660
acaaaaatga agtgggcatc aatgacgtca cctcctcaag aagctttgaa cgcattgaac
       670        680        690        700        710        720
gaattcttcg gtcataaagg attccgagaa aagcagtggg atgttgtcag aaatgttttg
       730        740        750        760        770        780
ggaggaaaag accaatttgt tcttatgtcc actggttatg gtaaaagtgt atgttatcag
       790        800        810        820        830        840
ctaccatcac ttcttctcaa ttcgatgact gtcgtggtat ctccattaat ttcattgatg
       850        860        870        880        890        900
aatgatcaag taactacatt ggtttctaaa ggtattgatg cagtgaaact agatggacat
       910        920        930        940        950        960
tctacacaaa ttgaatggga tcaagttgcg aataatatgc accgaattag gttcatctac
       970        980        990       1000       1010       1020
atgtcacctg aaatggttac gagccaaaag ggtttggaat tattaacttc ttgccgaaaa
      1030       1040       1050       1060       1070       1080
catatctccc tcctcgctat tgatgaagct cattgtgttt ctcaatgggg acacgacttt
      1090       1100       1110       1120       1130       1140
cgaaactcgt acaggcatct cgcagaaatt agaaaccgat ctgatctatg caatattcca
      1150       1160       1170       1180       1190       1200
atgattgctc ttaccgctac tgccacagtt agagttcgtg atgacgtcat tgctaattta
      1210       1220       1230       1240       1250       1260
agactccgca agccattaat cacaactacg tcgtttgata gaaagaatct ctacatttct
      1270       1280       1290       1300       1310       1320
gtgcattctt caaaggacat ggctgaagat ttaggattat tcatgaaaac cgatgaagtt
      1330       1340       1350       1360       1370       1380
aaaggaagac actttggtgg acctactatt atttattgcc aaacgaaaca aatggtcgat
      1390       1400       1410       1420       1430       1440
gatgtgaact gtgttttgag aagaatcgga gttcgttctg ctcattatca cgcaggactc
      1450       1460       1470       1480       1490       1500
actaaaaatc aacgagaaaa agcacacacc gattttatga gagataagat tacaacaatc
      1510       1520       1530       1540       1550       1560
gttgcgacag ttgcatttgg tatgggaatt gacaaacccg acgttcgaaa tgtgattcat
      1570       1580       1590       1600       1610       1620
tacggatgcc cgaacaatat cgaatcatat tatcaagaaa tcggaagagc tggtcgagat
      1630       1640       1650       1660       1670       1680
ggatctccaa gtatttgtcg tgtattctgg gctccgaaag atttgaatac tataaaattt
      1690       1700       1710       1720       1730       1740
aaacttcgaa attcgcagca aaaagaagaa gtagttgaaa atcttacaat gatgctaaga
      1750       1760       1770       1780       1790       1800
caactcgagt tggttctgac aaccgttgga tgtagaagat accaacttct gaagcacttt
      1810       1820       1830       1840       1850       1860
gacccatcat acgcgaaacc tccaactatg caagctgatt gttgtgatag atgtactgaa
      1870       1880       1890       1900       1910       1920
atgctcaatg gaaatcaaga ttcatcatcc agtattgttg atgttacaac agaatcgaag
      1930       1940       1950       1960       1970       1980
tggttgtttc aagttattaa cgaaatgtac aacgggaaaa ctggtatcgg aaaaccaatc
      1990       2000       2010       2020       2030       2040
gaatttctga ggggatcgag taaagaagac tggcgaatca agaccacatc tcaacaaaaa
      2050       2060       2070       2080       2090       2100
ttgtttggaa ttggaaaaca tattcctgat aaatggtgga aagcacttgc agcatcactt
      2110       2120       2130       2140       2150       2160
cgaattgctg gttatcttgg agaagttagg ctgatgcaaa tgaaatttgg aagttgtatc
      2170       2180       2190       2200       2210       2220
actttgtccg aactcgggga acgatggctt ttgactggaa aagagatgaa aatcgatgcg
      2230       2240       2250       2260       2270       2280
acaccgattt tattgcaagg gaagaaagaa aaagccgcac cttcaactgt ccccggagct
      2290       2300       2310       2320       2330       2340
tcaagatctc agtcaactaa atcaagtaca gagattccaa ccaagattct cggagcgaat
      2350       2360       2370       2380       2390       2400
aagattcgtg aatacgagcc tgcaaatgaa aacgagcagc tgatgaactt gaaaaagcaa
      2410       2420       2430       2440       2450       2460
gaagtcactg gtcttccaga gaagattgat caactgcgct ctcgtcttga cgacattcgt
      2470       2480       2490       2500       2510       2520
gtaggaattg caaacatgca tgaagtagca ccattccaaa ttgtatcgaa tactgttctt
      2530       2540       2550       2560       2570       2580
gattgttttg ccaacttgag acctacctca gcctcgaatc tcgaaatgat tgatggaatg
      2590       2600       2610       2620       2630       2640
tcggctcagc agaaatctag atacggaaaa cgatttgtcg attgtgttgt acaattttca
      2650       2660       2670       2680       2690       2700
aaggaaactg gcattgcaac aaacgtcaat gccaacgata tgataccccc tgaacttatt
      2710       2720       2730       2740       2750       2760
tcaaaaatgc agaaagttct ctcggatgcg gtgagaagag tatacacaga gcatcttatt
      2770       2780       2790       2800       2810       2820
tcgagatcca ctgcgaaaga agtggcaact gctcgaggaa ttagtgaggg tactgtatat
      2830       2840       2850       2860       2870       2880
tcatatctcg cgatggcggt agaaaaagga ttacctcttc acttagacaa gttaaatgtc
      2890       2900       2910       2920       2930       2940
tccagaaaga atattgcaat ggctctaaat gcagttagag tacatttagg atcaaatgtt
      2950       2960       2970       2980       2990       3000
gccgtactga caccatgggt tgaagctatg ggagtcgtac ctgattttaa tcagttgaaa
      3010       3020       3030       3040       3050       3060
ttgatccggg caattcttat ttacgaatat ggattggata cgagtgagaa ccaagagaag
      3070       3080       3090       3100       3110       3120
ccagacatcc aatctatgcc gtccacttca aatccatcca ccatcaaaac agttccatca
      3130       3140       3150       3160       3170
acaccttcat cctctctcag agctcctcca ttgaagaaat tcaaacttta a

Last modification date: Oct. 2, 2011