Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA polymerase III subunit tau


DESCRIPTION:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
The tau chain serves as a scaffold to help in the dimerizaton of the core complex.
The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA.

MISCELLANEOUS:
The production of the two protein products from this region is due to programmed ribosomal frameshifting.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MSYQVLARKW RPQTFADVVG QEHVLTALAN GLSLGRIHHA YLFSGTRGVG KTSIARLLAK
        70         80         90        100        110        120
GLNCETGITA TPCGVCDNCR EIEQGRFVDL IEIDAASRTK VEDTRDLLDN VQYAPARGRF
       130        140        150        160        170        180
KVYLIDEVHM LSRHSFNALL KTLEEPPEHV KFLLATTDPQ KLPVTILSRC LQFHLKALDV
       190        200        210        220        230        240
EQIRHQLEHI LNEEHIAHEP RALQLLARAA EGSLRDALSL TDQAIASGDG QVSTQAVSAM
       250        260        270        280        290        300
LGTLDDDQAL SLVEAMVEAN GERVMALINE AAARGIEWEA LLVEMLGLLH RIAMVQLSPA
       310        320        330        340        350        360
ALGNDMAAIE LRMRELARTI PPTDIQLYYQ TLLIGRKELP YAPDRRMGVE MTLLRALAFH
       370        380        390        400        410        420
PRMPLPEPEV PRQSFAPVAP TAVMTPTQVP PQPQSAPQQA PTVPLPETTS QVLAARQQLQ
       430        440        450        460        470        480
RVQGATKAKK SEPAAATRAR PVNNAALERL ASVTDRVQAR PVPSALEKAP AKKEAYRWKA
       490        500        510        520        530        540
TTPVMQQKEV VATPKALKKA LEHEKTPELA AKLAAEAIER DPWAAQVSQL SLPKLVEQVA
       550        560        570        580        590        600
LNAWKEESDN AVCLHLRSSQ RHLNNRGAQQ KLAEALSMLK GSTVELTIVE DDNPAVRTPL
       610        620        630        640
EWRQAIYEEK LAQARESIIA DNNIQTLRRF FDAELDEESI RPI 

Encoded by dnaX gene


OTHER NAME(S):
dnaZ
ECK0464
JW0459


DESCRIPTION:
The tau chain is the full length protein. [More information is available at EcoGene: EG10245]. The gamma subunit of polymerase III is generated by a programmed frameshift that occurs about half the time and leads to early termination of translation and a protein that lacks the final two domains found in tau. [More information is available at EcoCyc: EG10245].


Nucleic acid sequence

        10         20         30         40         50         60
atgagttatc aggtcttagc ccgaaaatgg cgcccacaaa cctttgctga cgtcgtcggc
        70         80         90        100        110        120
caggaacatg tgctgaccgc actggcgaac ggcttgtcgt tagggcgtat tcatcatgct
       130        140        150        160        170        180
tatctttttt ccggcacccg tggcgtcgga aaaacctcta tcgcccgact gctggcgaag
       190        200        210        220        230        240
gggctaaact gcgaaaccgg cattaccgcg acgccgtgcg gcgtgtgcga taactgtcgt
       250        260        270        280        290        300
gaaatcgagc aggggcgctt tgtcgatctg attgaaatcg acgccgcctc gcgcaccaaa
       310        320        330        340        350        360
gttgaagata cccgcgacct gctggataac gtccagtacg ctccggcgcg tggtcgtttc
       370        380        390        400        410        420
aaagtttatc tgatcgacga agtgcatatg ctgtcgcgcc acagctttaa cgcactgtta
       430        440        450        460        470        480
aaaacccttg aagagccgcc ggagcacgtt aagtttctgc tggcgacgac cgatccacag
       490        500        510        520        530        540
aaattgccgg tgacgatttt gtcacgctgt ctgcaatttc atctcaaggc gctggatgtc
       550        560        570        580        590        600
gagcaaattc gccatcagct tgagcacatc ctcaacgaag aacatatcgc tcacgagccg
       610        620        630        640        650        660
cgggcgctgc aattgctggc acgcgccgct gaaggcagcc tgcgagatgc cttaagtctg
       670        680        690        700        710        720
accgaccagg cgattgccag cggtgacggc caggtttcaa cccaggcggt cagtgcgatg
       730        740        750        760        770        780
ctgggtacgc ttgacgacga tcaggcgctg tcgctggttg aagcgatggt cgaggccaac
       790        800        810        820        830        840
ggcgagcgcg taatggcgct gattaatgaa gccgctgccc gtggtatcga gtgggaagcg
       850        860        870        880        890        900
ttgctggtgg aaatgctcgg cctgttgcat cgtattgcga tggtacaact ttcgcctgct
       910        920        930        940        950        960
gcacttggca acgacatggc cgccatcgag ctgcggatgc gtgaactggc gcgcaccata
       970        980        990       1000       1010       1020
ccgccgacgg atattcagct ttactatcag acgctgttga ttggtcgcaa agaattaccg
      1030       1040       1050       1060       1070       1080
tatgcgccgg accgtcgcat gggcgttgag atgacgctgc tgcgcgcgct ggcattccat
      1090       1100       1110       1120       1130       1140
ccgcgtatgc cgctgcctga gccagaagtg ccacgacagt cctttgcacc cgtcgcgcca
      1150       1160       1170       1180       1190       1200
acggcagtaa tgacgccaac ccaggtgccg ccgcaaccgc aatcagcgcc gcagcaggca
      1210       1220       1230       1240       1250       1260
ccgactgtac cgctcccgga aaccaccagc caggtgctgg cggcgcgcca gcagttgcag
      1270       1280       1290       1300       1310       1320
cgcgtgcagg gagcaaccaa agcaaaaaag agtgaaccgg cagccgctac ccgcgcgcgg
      1330       1340       1350       1360       1370       1380
ccggtgaata acgctgcgct ggaaagactg gcttcggtca ccgatcgcgt tcaggcgcgt
      1390       1400       1410       1420       1430       1440
ccggtgccat cggcgctgga aaaagcgcca gccaaaaaag aagcgtatcg ctggaaggcg
      1450       1460       1470       1480       1490       1500
accactccgg tgatgcagca aaaagaagtg gtcgccacgc cgaaggcgct gaaaaaagcg
      1510       1520       1530       1540       1550       1560
ctggaacatg aaaaaacgcc ggaactggcg gcgaagctag cggcagaagc cattgagcgc
      1570       1580       1590       1600       1610       1620
gacccgtggg cggcacaggt gagccaactt tcgctaccaa aactggtcga acaggtggcg
      1630       1640       1650       1660       1670       1680
ttaaatgcct ggaaagagga gagcgacaac gcagtatgtc tgcatttgcg ctcctctcag
      1690       1700       1710       1720       1730       1740
cggcatttga acaaccgcgg tgcacagcaa aaactggctg aagcgttgag catgttaaaa
      1750       1760       1770       1780       1790       1800
ggttcaacgg ttgaactgac tatcgttgaa gatgataatc ccgcggtgcg tacgccgctg
      1810       1820       1830       1840       1850       1860
gagtggcgtc aggcgatata cgaagaaaaa cttgcgcagg cgcgcgagtc cattattgcg
      1870       1880       1890       1900       1910       1920
gataataata ttcagaccct gcgtcggttc ttcgatgcgg agctggatga agaaagtatc
      1930
cgccccattt ga    

Last modification date: Oct. 2, 2011