Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Cullin-4


DESCRIPTION:
Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1.

STRUCTURE SIMILARITY:
Belongs to the cullin family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MTSGAPPTIS TEKSRSKQLR KSSKRTASTV EGTEAKQMRG DTENRSDGEM DDVSTSSEIR
        70         80         90        100        110        120
HGNGFIENFR SQTGNSSRTT ATNERIKKKL VIKNFKANAN QNDVAMGDTN IDSTDGSVGR
       130        140        150        160        170        180
DWAVLSDNVF AILEDRKTVT TLEGLFSKVR SVCDKNQSKV LYDRLVAIVV QFAKSLKESL
       190        200        210        220        230        240
NAVEQVPLAE DNCEQYLEKF GQIWQAYPVK INLIRNIFLH LDRIALGATD TEILPLWECF
       250        260        270        280        290        300
MQIFQKTFFP NIFKEFKATK LFNALYMAMQ KIMQRYPVDS PLRSLVDMLQ TVHVSEEFAK
       310        320        330        340        350        360
FLISQLREHY NNERIDKVPK MNCNDYMEYC EDQINRYSQL VKVNFDEPSA LKDVQATVTN
       370        380        390        400        410        420
CLIQQAIPEI LTHDFDDLID SDNISDIGRM FNLCRQCVGG EDEVRTQFSK YLKKRGEKLI
       430        440        450        460        470        480
ATCPDEDLVS ELLAFKKKVD FIMTGSFKSA NDPVKMRQCL SDAFESFVNK QVDRSAELIS
       490        500        510        520        530        540
KHFHTLLHSS NKNVSDDTTL DQMVDEAIVL FRYLRGKDVF EAYYKRGLAK RLFLERSASV
       550        560        570        580        590        600
DAEKMVLCKL KTECGSAFTY KLEGMFKDMD ASENYGRLFN QYLEHMNKEK ANFTARVITP
       610        620        630        640        650        660
EYWPTYDTYE INIPKEMRDT LTDYQDFYRV QHGNRNVKWH HGLASAVISA SFRPGCKKEL
       670        680        690        700        710        720
IATMYQTVIL LLFNKCETWT VAEIVEHTKI LEIEVVKNVL ALLGGRDKPK VLQRVEGGGS
       730        740        750        760        770        780
EKKEGTVENL KNEKFVVNSK FTEKRCRVRI AQVNIKTAVE ETKEVKEEVN SDRQYKIDAA
       790        800        810        820        830        840
VVRIMKARKQ LNHQTLMTEL LQQLRFPVST ADIKKRLESL IEREYISRDP EEASSYNYVA

Encoded by cul-4 gene

FULL NAME: CULlin


Nucleic acid sequence

        10         20         30         40         50         60
atgacatctg gagcaccacc gactatttca acagaaaaaa gtcgaagtaa acagcttcga
        70         80         90        100        110        120
aaatcgtcaa agcgcacagc cagcaccgtt gaaggtacag aggctaagca aatgcgcggc
       130        140        150        160        170        180
gacactgaaa atcgttccga cggagaaatg gacgatgttt caacaagcag cgaaatcaga
       190        200        210        220        230        240
catggaaatg gatttattga gaatttcaga agtcaaaccg gcaattcttc acgcacaacc
       250        260        270        280        290        300
gcaacaaatg aacgcatcaa aaagaaactt gtgataaaga actttaaagc gaacgcgaat
       310        320        330        340        350        360
caaaatgatg ttgcgatggg ggacaccaat attgatagta cagacggatc agttggtaga
       370        380        390        400        410        420
gattgggctg ttctttcgga taatgttttc gctattcttg aagataggaa aacagtaacc
       430        440        450        460        470        480
actttggaag gcttattcag caaggtcaga tctgtgtgcg ataaaaatca atcaaaagta
       490        500        510        520        530        540
ctttacgatc gtctcgttgc aattgttgtt cagtttgcaa aatcattaaa ggagtcgtta
       550        560        570        580        590        600
aatgcggttg agcaagttcc tcttgcagaa gacaattgtg agcaatattt ggaaaagttt
       610        620        630        640        650        660
gggcagatct ggcaagcata tccagttaaa atcaatctca tcaggaatat ttttcttcat
       670        680        690        700        710        720
ctggaccgaa ttgcgctcgg cgctacagac acagaaattc tccctttgtg ggaatgtttc
       730        740        750        760        770        780
atgcaaatat ttcaaaaaac attcttcccg aacattttca aggaattcaa agcaacaaaa
       790        800        810        820        830        840
ctgttcaatg ctctctatat ggcgatgcag aaaattatgc agaggtatcc agtggacagt
       850        860        870        880        890        900
cctctcagaa gtcttgtaga tatgcttcaa acagttcatg tgtctgaaga atttgcaaaa
       910        920        930        940        950        960
ttccttatta gccaacttcg agagcactat aacaatgaga gaatcgataa agttccaaaa
       970        980        990       1000       1010       1020
atgaattgca acgattacat ggaatactgt gaagaccaga taaatcgata ttcgcaatta
      1030       1040       1050       1060       1070       1080
gtgaaagtga actttgatga accgtcggct ctaaaagatg ttcaggcaac agtgacaaac
      1090       1100       1110       1120       1130       1140
tgtctcattc aacaagcaat tcctgaaatt ctcacacatg attttgacga tcttatcgat
      1150       1160       1170       1180       1190       1200
tctgataaca tttcggatat cggccgaatg tttaatttgt gccgtcaatg cgttggtgga
      1210       1220       1230       1240       1250       1260
gaggatgaag tacgtacaca attctcaaag tatttgaaaa aacgcggaga gaaattgatt
      1270       1280       1290       1300       1310       1320
gctacgtgtc ctgatgaaga tcttgtttct gagctacttg ctttcaagaa gaaagttgat
      1330       1340       1350       1360       1370       1380
tttatcatga ctggaagctt caaatccgca aatgatccag taaaaatgag acaatgtttg
      1390       1400       1410       1420       1430       1440
tcagatgcct ttgaatcttt tgtaaataaa caagtcgatc gatctgcaga acttatttca
      1450       1460       1470       1480       1490       1500
aagcacttcc acacacttct tcacagtagc aataaaaatg tatcagacga cacaactctc
      1510       1520       1530       1540       1550       1560
gatcaaatgg tagatgaagc tattgtgttg ttccgatatc ttcgtggaaa agacgttttt
      1570       1580       1590       1600       1610       1620
gaagcatatt ataaaagagg tcttgctaag cggcttttcc ttgaaagaag tgcatctgtt
      1630       1640       1650       1660       1670       1680
gatgctgaaa agatggtttt atgcaagtta aagacagagt gtggctcggc gttcacatac
      1690       1700       1710       1720       1730       1740
aaattggaag gaatgttcaa agatatggat gcatctgaaa attatggaag attattcaac
      1750       1760       1770       1780       1790       1800
caatatctag aacatatgaa caaagaaaaa gcgaatttca ctgctcgagt cataactcca
      1810       1820       1830       1840       1850       1860
gaatattggc caacctatga cacatatgaa attaatattc caaaagagat gagagataca
      1870       1880       1890       1900       1910       1920
cttaccgatt atcaagattt ttaccgtgtt caacatggaa atcggaatgt taaatggcat
      1930       1940       1950       1960       1970       1980
cacggactgg cttctgcggt tatttctgct tcattcaggc ctggatgtaa gaaagaatta
      1990       2000       2010       2020       2030       2040
attgcaacaa tgtatcaaac tgtcattctt cttcttttca acaaatgtga gacatggact
      2050       2060       2070       2080       2090       2100
gtcgctgaaa ttgttgagca cactaagatt ctggaaattg aagtcgtcaa aaatgtgctt
      2110       2120       2130       2140       2150       2160
gcacttcttg gtggacgtga taagcctaag gttttgcaga gagtcgaagg aggtggatcc
      2170       2180       2190       2200       2210       2220
gaaaagaagg aaggtactgt ggaaaatttg aaaaacgaga aatttgttgt aaattctaaa
      2230       2240       2250       2260       2270       2280
ttcacggaga agcgctgccg agttaggatt gctcaggtca atataaagac agctgtggaa
      2290       2300       2310       2320       2330       2340
gagacgaagg aagtgaaaga agaagtgaat tctgatcgac aatacaaaat tgacgctgct
      2350       2360       2370       2380       2390       2400
gttgtaagaa ttatgaaggc tcgaaagcag ctaaaccatc aaactctaat gacggagtta
      2410       2420       2430       2440       2450       2460
ttgcaacaat tgagattccc cgtgagcacc gccgatatca agaaacgcct ggaatcactc
      2470       2480       2490       2500       2510       2520
atcgaacgtg aatatatatc gagggatcct gaagaggcat ctagctataa ttatgttgcg

taa     

Last modification date: Oct. 2, 2011