Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: RING-box protein 1


DESCRIPTION:
Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.

STRUCTURE SIMILARITY:
Contains 1 RING-type zinc finger.
Belongs to the RING-box family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAQASDSTAM EVEEATNQTV KKRFEVKKWS AVALWAWDIQ VDNCAICRNH IMDLCIECQA
        70         80         90        100        110
NQAAGLKDEC TVAWGNCNHA FHFHCISRWL KTRQVCPLDN REWEFQKYGH 

Encoded by rbx-1 gene

FULL NAME: yeast RBX (ring finger protein) homolog


Nucleic acid sequence

        10         20         30         40         50         60
atggcccaag caagcgacag cacagctatg gaggtcgagg aggccacaaa tcagacagtt
        70         80         90        100        110        120
aagaagcgtt tcgaggtcaa gaaatggagt gccgtcgcac tttgggcctg ggacattcag
       130        140        150        160        170        180
gtcgacaact gcgctatttg ccgcaatcac atcatggatc tgtgcatcga gtgccaagcg
       190        200        210        220        230        240
aatcaagcag ccgggctcaa ggatgagtgt accgttgcat ggggaaactg taatcacgct
       250        260        270        280        290        300
ttccacttcc attgcatttc tcgttggctg aagacacgac aggtatgccc attggacaat
       310        320        330
cgtgagtggg aattccaaaa gtacggacac taa  

Last modification date: Oct. 2, 2011