Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA repair protein rad14


DESCRIPTION:
Involved in nucleotide excision repair (NER). Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance. Binds damaged DNA. Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides. Maintains GT repeat stability. Functions as a part of the short-patch excision repair system.

STRUCTURE SIMILARITY:
Belongs to the XPA family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MENSSIVKSP NPTIEEQRNE IEKLKNLTGI EEVHVDGAKV NKRKRTFDEQ SEITKDYIEY
        70         80         90        100        110        120
DFSKIEDTKG GYLLEEKKVE DLREKPAERE LREQEERQKK LRLAPLNLDP ETAPKCFECD
       130        140        150        160        170        180
SIELDTKYFD IFHCRVCHTC REKYPDKYSL LTKTECKLDY LLTEPELQDQ ELLPRLLKAN
       190        200        210        220        230        240
PHQQGWSNMM LYLRYQVEEF AKKKWGSMEA LDAEFERREV QKKEMKEKKF EKQLLELRKR
       250        260        270        280
TRTSNYSRMS IREKRKHVHS YDEEFEKPNE PGVIVQRCKC GLEIEQLEI 

Encoded by rhp14 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggaaaatt cgtcaattgt caagtcaccg aatccaacaa tcgaggagca aagaaatgaa
        70         80         90        100        110        120
attgaaaagt taaagaatct cacaggtata gaagaggttc acgttgatgg tgcaaaagtt
       130        140        150        160        170        180
aataaaagga agcgtacttt tgatgagcag tcggagataa ccaaagatta catcgagtat
       190        200        210        220        230        240
gatttttcca agattgaaga tactaaaggt ggttatcttc ttgaagaaaa gaaagttgaa
       250        260        270        280        290        300
gacttaaggg agaaaccggc tgagcgagag cttagagagc aagaagaacg ccaaaaaaag
       310        320        330        340        350        360
cttaggctag cacctcttaa tctagaccca gaaacggcac caaaatgctt cgagtgcgac
       370        380        390        400        410        420
tccatagaat tagacacaaa atattttgac atttttcatt gtagggtgtg tcatacgtgt
       430        440        450        460        470        480
cgggagaaat atccggataa atactccttg ctaaccaaaa cggagtgcaa gttagattat
       490        500        510        520        530        540
ttgcttacgg aaccggaatt gcaagatcaa gaacttttac ctcgactgtt aaaggcaaat
       550        560        570        580        590        600
ccacatcagc aaggctggtc caacatgatg ttatatcttc gctatcaagt tgaggaattt
       610        620        630        640        650        660
gcaaagaaaa aatggggttc tatggaagct cttgacgcgg aatttgagag gagagaagta
       670        680        690        700        710        720
caaaagaagg agatgaaaga gaagaagttt gaaaagcagc ttttggagct tcgaaagaga
       730        740        750        760        770        780
acacggacaa gtaattacag tcgaatgagt attcgtgaaa agcgaaaaca tgttcattct
       790        800        810        820        830        840
tatgatgagg aatttgagaa acctaatgaa cccggtgtaa ttgtacaaag atgtaaatgt
       850        860        870
ggcttggaaa ttgagcagct ggaaatttaa   

Last modification date: Oct. 2, 2011