Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA repair protein rad13


DESCRIPTION:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair (Probable).

STRUCTURE SIMILARITY:
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
Contains 1 UIM (ubiquitin-interacting motif) repeat.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MGVSGLWDIL EPVKRPVKLE TLVNKRLAID ASIWIYQFLK AVRDKEGNQL KSSHVVGFFR
        70         80         90        100        110        120
RICKLLFFGI KPVFVFDGGA PSLKRQTIQK RQARRLDREE NATVTANKLL ALQMRHQAML
       130        140        150        160        170        180
LEENNKKATA LANASVQNER QMPSSMTLDN SEIKPVLNQR KNYLKPDPYQ LPEMDVSFDK
       190        200        210        220        230        240
LGSSYDPRIM SQDELTQYVS SFTKIEDINL FDFSNIDFDS ELFQSLPDTD KYSILSAARL
       250        260        270        280        290        300
RSRLRMGLSS EQLSEMFPNR MDFSRFQIER LKERNDLTQR LMDFTGMNEF GPSRVVSEKN
       310        320        330        340        350        360
REYILVKNEG AEGGWALGVI SGSTNNEPII IDDEATKLSS NLIDEDEDEA FYDVPLPSRS
       370        380        390        400        410        420
HSMNPRELVA AKLKEIKENS FSENQQSDEA DYNVTDDLIL QLATQQSLEE NKKSKELFSL
       430        440        450        460        470        480
SASEFDKLNS EKKTFEILST DIPAEDSMNS LLNDEENLKL EHVGDVSNDS LAFAEKKHPE
       490        500        510        520        530        540
NGTSIFMDAL PSASREKKTN DLIDPLPFQP MDWGKSIFFE KLKKPTETFM DSKTDIPSEA
       550        560        570        580        590        600
PDNSKLVEDT NLHTINATVN IESDLDAAKP GIENPIISPL LPVKDDEKDL DLRELNPLEP
       610        620        630        640        650        660
FENMKEQADD GTVTNPLNVS SDKAMSVYLL SSENAKDTGD IKSESIDAVL PTLETSSPSL
       670        680        690        700        710        720
SIPTDFQKEA SPNKGAAALS SKVEPEVVEK LLDEEEEEMI IRMAEEEKEY DRFVSELNQR
       730        740        750        760        770        780
HETEEWNQEA FEKRLKELKN QKRSEKRDAD EVTQVMIKEC QELLRLFGLP YIVAPQEAEA
       790        800        810        820        830        840
QCSKLLELKL VDGIVTDDSD VFLFGGTRVY RNMFNQNKFV ELYLMDDMKR EFNVNQMDLI
       850        860        870        880        890        900
KLAHLLGSDY TMGLSRVGPV LALEILHEFP GDTGLFEFKK WFQRLSTGHA SKNDVNTPVK
       910        920        930        940        950        960
KRINKLVGKI ILPSEFPNPL VDEAYLHPAV DDSKQSFQWG IPDLDELRQF LMATVGWSKQ
       970        980        990       1000       1010       1020
RTNEVLLPVI QDMHKKQFVG TQSNLTQFFE GGNTNVYAPR VAYHFKSKRL ENALSSFKNQ
      1030       1040       1050       1060       1070       1080
ISNQSPMSEE IQADADAFGE SKGSDELQSR ILRRKKMMAS KNSSDSDSDS EDNFLASLTP
      1090       1100       1110
KTNSSSISIE NLPRKTKLST SLLKKPSKRR RK  

Encoded by rad13 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgggggttt caggtctttg ggatatttta gaaccggtaa aaaggcctgt caagctagaa
        70         80         90        100        110        120
acacttgtta acaaacggtt ggcaattgac gcttcaattt ggatttatca attcttaaag
       130        140        150        160        170        180
gccgtacgtg acaaagaagg aaaccagctg aaaagcagtc atgttgtagg attttttaga
       190        200        210        220        230        240
aggatatgca aactattatt ttttgggatt aaacctgtat ttgtttttga tggaggagcg
       250        260        270        280        290        300
ccgtcattga aacgccaaac tatccaaaaa agacaagcca gaagactcga cagggaggaa
       310        320        330        340        350        360
aatgccacgg tcacggccaa taaacttctg gctttgcaaa tgaggcatca ggcaatgctt
       370        380        390        400        410        420
ttagaggaaa ataataaaaa agctactgca ttggcaaatg cctcggttca aaatgagaga
       430        440        450        460        470        480
caaatgcctt catctatgac attggataat tcagaaatta agccagtact taatcaaaga
       490        500        510        520        530        540
aaaaattatt tgaagcctga tccataccaa ctacctgaaa tggacgtttc gtttgataag
       550        560        570        580        590        600
ttagggtcga gttacgaccc tcgaattatg tcccaggatg agcttacaca atatgtctct
       610        620        630        640        650        660
agttttacta aaattgaaga tataaattta tttgattttt caaatattga ttttgactct
       670        680        690        700        710        720
gaattatttc aatcattacc cgatacggat aaatatagta ttttaagtgc agcaagatta
       730        740        750        760        770        780
cgctctcgtt tacgaatggg tttaagctct gaacaacttt ccgagatgtt tcctaataga
       790        800        810        820        830        840
atggatttct ctcgttttca aattgagaga ctgaaggaac gtaacgattt aactcagaga
       850        860        870        880        890        900
ttaatggact ttactggaat gaatgagttt ggaccctcta gagtagtaag tgaaaaaaac
       910        920        930        940        950        960
cgagaatata ttttagtaaa aaacgaaggt gctgaaggtg gatgggctct cggtgttatc
       970        980        990       1000       1010       1020
tcaggatcta caaacaatga acctattatt attgatgatg aggctacaaa acttagcagc
      1030       1040       1050       1060       1070       1080
aatcttatag acgaagacga ggatgaggca ttctacgatg tgcctttacc tagccgatct
      1090       1100       1110       1120       1130       1140
catagcatga accctagaga attggtagcc gctaaattaa aggaaataaa agaaaattca
      1150       1160       1170       1180       1190       1200
ttttcggaaa atcagcaatc agatgaagca gattataatg ttactgatga tttaatactt
      1210       1220       1230       1240       1250       1260
caattagcaa cccagcaatc tctagaggaa aacaaaaaat caaaagagct gtttagtctt
      1270       1280       1290       1300       1310       1320
tcggcttctg agtttgataa gttgaatagc gagaaaaaga cgtttgaaat tttgtcgacc
      1330       1340       1350       1360       1370       1380
gatattcctg cagaggattc aatgaattca cttcttaacg acgaggaaaa tttgaaactt
      1390       1400       1410       1420       1430       1440
gaacatgttg gagatgtttc caatgattca ttagcattcg cggaaaaaaa gcatcctgaa
      1450       1460       1470       1480       1490       1500
aatgggactt caatttttat ggatgccctt ccatctgcga gtagagagaa aaaaaccaat
      1510       1520       1530       1540       1550       1560
gatttaattg atcctttacc ttttcagcct atggattggg gaaagtctat ttttttcgag
      1570       1580       1590       1600       1610       1620
aaattaaaga aaccaactga aacatttatg gattctaaaa ctgatatacc aagtgaggca
      1630       1640       1650       1660       1670       1680
ccggataatt ctaaacttgt ggaagataca aatttacata ctattaatgc aacagttaat
      1690       1700       1710       1720       1730       1740
attgaatccg atttagacgc tgctaaacct ggaattgaaa atccaattat ttcacctctt
      1750       1760       1770       1780       1790       1800
cttccggtaa aagatgatga aaaagattta gacttacgtg aactcaatcc tttggaaccc
      1810       1820       1830       1840       1850       1860
tttgagaata tgaaagaaca agctgatgat ggcacagtta ccaacccatt aaatgtttct
      1870       1880       1890       1900       1910       1920
agtgataagg ccatgtcagt gtatttattg agctccgaaa atgctaagga tactggggat
      1930       1940       1950       1960       1970       1980
atcaaatccg aatcaattga cgctgttctt cctactttag agaccagcag cccttcactt
      1990       2000       2010       2020       2030       2040
agcattccaa ctgactttca aaaagaagcc tctccaaata aaggagctgc tgccttgagt
      2050       2060       2070       2080       2090       2100
tcgaaagtag agcctgaagt ggttgaaaaa cttttagatg aggaagaaga ggaaatgatt
      2110       2120       2130       2140       2150       2160
atcaggatgg cagaagaaga aaaggaatat gatcggtttg tttcagaact caatcaacga
      2170       2180       2190       2200       2210       2220
catgaaactg aagagtggaa tcaagaggcc tttgaaaaaa ggttgaaaga gctcaaaaat
      2230       2240       2250       2260       2270       2280
caaaaaaggt ctgaaaaacg tgatgcggat gaggtcactc aagtaatgat taaagaatgt
      2290       2300       2310       2320       2330       2340
caagaacttc tgcgtttatt tggcttacca tatatcgttg ctcctcaaga agcagaagcc
      2350       2360       2370       2380       2390       2400
cagtgttcta aacttttgga gctaaagctg gttgatggga ttgttactga tgactcagac
      2410       2420       2430       2440       2450       2460
gtgtttcttt ttggtggaac tcgggtatat cgaaatatgt ttaatcagaa caaatttgtc
      2470       2480       2490       2500       2510       2520
gaactctatt taatggatga tatgaaaaga gaatttaatg tgaatcaaat ggatttaatt
      2530       2540       2550       2560       2570       2580
aagttggcac atcttttggg aagtgattat actatgggac tttctagggt aggtccagtt
      2590       2600       2610       2620       2630       2640
cttgcactgg agattttaca tgaatttcct ggtgacactg gactttttga atttaaaaaa
      2650       2660       2670       2680       2690       2700
tggtttcaac gtttatcaac tggacacgca tcaaaaaatg atgttaatac gccagtaaaa
      2710       2720       2730       2740       2750       2760
aagagaatta acaagttggt tggaaaaatt attttaccat cagaatttcc taatccgtta
      2770       2780       2790       2800       2810       2820
gttgatgaag cttatcttca tccggccgtg gatgatagca agcaatcgtt tcaatggggc
      2830       2840       2850       2860       2870       2880
atacccgacc ttgacgagtt acgccagttt ttgatggcta ctgtgggttg gtcaaaacaa
      2890       2900       2910       2920       2930       2940
cgaactaatg aagttttact tccggttata caagacatgc ataaaaagca attcgtgggt
      2950       2960       2970       2980       2990       3000
acacagtcca atttgactca gttttttgaa ggtggtaata ctaatgtata tgcgccgaga
      3010       3020       3030       3040       3050       3060
gttgcatacc attttaagag taaacggctt gaaaatgctc tttcatcttt taaaaatcag
      3070       3080       3090       3100       3110       3120
attagcaatc aaagcccaat gagtgaagaa attcaggcag acgcagatgc atttggtgaa
      3130       3140       3150       3160       3170       3180
tctaaaggat cagatgaact acaaagccgt attcttagaa ggaagaaaat gatggcaagc
      3190       3200       3210       3220       3230       3240
aaaaattcct ctgattcaga ttcagactct gaagataact ttttagcaag tttaactccg
      3250       3260       3270       3280       3290       3300
aagacgaatt cttcttcaat ttctattgag aatctaccta gaaaaaccaa gcttagtact
      3310       3320       3330
agcttactaa aaaaacccag caaaagaaga agaaaataa  

Last modification date: Oct. 2, 2011