Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA polymerase III subunit epsilon


DESCRIPTION:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
3'-5' exonuclease


RELATED PATHWAY(S):
DNA replication
mismatch repair (MMR)
homologous recombination (HR)


RELATED DAMAGE:
3'-OH end


Amino acids sequence

        10         20         30         40         50         60
MSTAITRQIV LDTETTGMNQ IGAHYEGHKI IEIGAVEVVN RRLTGNNFHV YLKPDRLVDP
        70         80         90        100        110        120
EAFGVHGIAD EFLLDKPTFA EVADEFMDYI RGAELVIHNA AFDIGFMDYE FSLLKRDIPK
       130        140        150        160        170        180
TNTFCKVTDS LAVARKMFPG KRNSLDALCA RYEIDNSKRT LHGALLDAQI LAEVYLAMTG
       190        200        210        220        230        240
GQTSMAFAME GETQQQQGEA TIQRIVRQAS KLRVVFATDE EIAAHEARLD LVQKKGGSCL

WRA     

Encoded by dnaQ gene


OTHER NAME(S):
ECK0215
JW0205
mutD


DESCRIPTION:
The epsilon subunit of DNA polymerase III catalyzes the 3' to 5' proofreading exonuclease activity of the holoenzyme . [More information is available at EcoCyc: EG10243].


Nucleic acid sequence

        10         20         30         40         50         60
atgagcactg caattacacg ccagatcgtt ctcgataccg aaaccaccgg tatgaaccag
        70         80         90        100        110        120
attggtgcgc actatgaagg ccacaagatc attgagattg gtgccgttga agtggtgaac
       130        140        150        160        170        180
cgtcgcctga cgggcaataa cttccatgtt tatctcaaac ccgatcggct ggtggatccg
       190        200        210        220        230        240
gaagcctttg gcgtacatgg tattgccgat gaatttttgc tcgataagcc cacgtttgcc
       250        260        270        280        290        300
gaagtagccg atgagttcat ggactatatt cgcggcgcgg agttggtgat ccataacgca
       310        320        330        340        350        360
gcgttcgata tcggctttat ggactacgag ttttcgttgc ttaagcgcga tattccgaag
       370        380        390        400        410        420
accaatactt tctgtaaggt caccgatagc cttgcggtgg cgaggaaaat gtttcccggt
       430        440        450        460        470        480
aagcgcaaca gcctcgatgc gttatgtgct cgctacgaaa tagataacag taaacgaacg
       490        500        510        520        530        540
ctgcacgggg cattactcga tgcccagatc cttgcggaag tttatctggc gatgaccggt
       550        560        570        580        590        600
ggtcaaacgt cgatggcttt tgcgatggaa ggagagacac aacagcaaca aggtgaagca
       610        620        630        640        650        660
acaattcagc gcattgtacg tcaggcaagt aagttacgcg ttgtttttgc gacagatgaa
       670        680        690        700        710        720
gagattgcag ctcatgaagc ccgtctcgat ctggtgcaga agaaaggcgg aagttgcctc
       730
tggcgagcat aa    

Last modification date: Oct. 2, 2011