Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Serine/threonine-protein kinase crk1


DESCRIPTION:
Protein kinase essential for cell proliferation, where it is required for completion of cytokinesis. Phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MDIEKSDKWT YVKERKVGEG TYAVVFLGRQ KETNRRVAIK KIKVGQFKDG IDISALREIK
        70         80         90        100        110        120
FLRESRHDNV IELVDVFSTK SNLNIILEFL DSDLEMLIKD KFIVFQPAHI KSWMVMLLRG
       130        140        150        160        170        180
LHHIHSRFIL HRDLKPNNLL ISSDGVLKLA DFGLSRDFGT PSHMSHQVIT RWYRPPELFM
       190        200        210        220        230        240
GCRSYGTGVD MWSVGCIFAE LMLRTPYLPG ESDLDQLNVI FRALGTPEPE VIKSMQQLPN
       250        260        270        280        290        300
YVEMKHIPPP NGGMEALFSA AGHEEIDLLK MMLDYNPYRR PTAQQALEHH YFSALPKPTH
       310        320        330
PSLLPRKGGE EGIKHVSSDL QRQNNFPMRA NIKFV  

Encoded by mcs6 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggatatcg aaaagtctga caagtggacg tatgtgaagg agcgcaaagt tggtgaagga
        70         80         90        100        110        120
acgtatgccg tcgtgttcct gggtcgccaa aaagaaacta atcggcgtgt ggctattaaa
       130        140        150        160        170        180
aagattaaag tgggccagtt caaagatggt atcgatataa gtgctttacg agagatcaaa
       190        200        210        220        230        240
tttcttcggg agtcaaggca cgacaatgtc atcgagttag ttgatgtatt ctccacaaag
       250        260        270        280        290        300
tccaacctca acatcatctt ggaattcctg gacagtgatt tggaaatgct gatcaaagac
       310        320        330        340        350        360
aaattcatcg tttttcaacc tgcccacatc aaatcgtgga tggtcatgtt gttacgcggt
       370        380        390        400        410        420
ttgcatcaca ttcattctcg cttcatcctt catcgagatt tgaagcctaa taacctttta
       430        440        450        460        470        480
atttcgagtg acggtgtcct aaaattggct gattttggcc tttctcgtga ttttggcacc
       490        500        510        520        530        540
ccaagccaca tgagtcatca ggtcattaca cgatggtaca ggcctccaga gctatttatg
       550        560        570        580        590        600
ggttgtcgaa gctatggcac cggtgttgat atgtggagtg taggctgcat ttttgcagag
       610        620        630        640        650        660
ttgatgctta ggaccccgta tttgccaggc gaatctgatc tggatcagct taacgtaatt
       670        680        690        700        710        720
ttccgcgctc ttggaactcc tgaaccagag gtcattaaaa gcatgcaaca gcttcccaac
       730        740        750        760        770        780
tacgttgaga tgaaacacat tcctcctcct aacggtggta tggaggctct tttttcggca
       790        800        810        820        830        840
gctggccatg aagaaattga tttactcaag atgatgttgg attacaatcc atatcgtcgt
       850        860        870        880        890        900
cccactgctc aacaagccct tgagcatcat tatttttctg cccttcctaa acccacacat
       910        920        930        940        950        960
ccttctcttc tcccacgcaa agggggtgag gaaggaatca agcacgtctc tagtgacctg
       970        980        990       1000
cagcgacaaa acaactttcc aatgcgtgca aatattaaat ttgtttaa 

Last modification date: Oct. 2, 2011