Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA polymerase III subunit theta


DESCRIPTION:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
The exact function of the theta subunit is unknown.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MLKNLAKLDQ TEMDKVNVDL AAAGVAFKER YNMPVIAEAV EREQPEHLRS WFRERLIAHR
        70
LASVNLSRLP YEPKLK    

Encoded by holE gene


OTHER NAME(S):
ECK1843
JW1831


DESCRIPTION:
The theta subunit of DNA polymerase III binds tightly to the epsilon subunit but not to the alpha subunit . [More information is available at EcoCyc: EG11505].


Nucleic acid sequence

        10         20         30         40         50         60
atgctgaaga atctggctaa actggatcaa acagaaatgg ataaagtgaa tgtcgatttg
        70         80         90        100        110        120
gcggcggccg gggtggcatt taaagaacgc tacaatatgc cggtgatcgc tgaagcggtt
       130        140        150        160        170        180
gaacgtgaac agcctgaaca tttgcgcagc tggtttcgcg agcggcttat tgcccaccgt
       190        200        210        220        230
ttggcttcgg tcaatctgtc acgtttacct tacgagccca aacttaaata a

Last modification date: Oct. 2, 2011