Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: RING-box protein pip1


DESCRIPTION:
Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.

STRUCTURE SIMILARITY:
Contains 1 RING-type zinc finger.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MEDEMQIDKK EVEIEQKPPR FEIKKWNAVA LWQWDIVVDN CAICRNHIMD LCIECQANTD
        70         80         90        100
SAAAQECTVA WGTCNHAFHF HCISRWLNTR NVCPLDNREW EFQRYGH 

Encoded by rbx1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggaagatg aaatgcaaat agacaagaag gaggtggaaa ttgaacaaaa acctcctcga
        70         80         90        100        110        120
tttgaaatta aaaagtggaa tgctgtagca ttatggcaat gggacattgt tgtagataac
       130        140        150        160        170        180
tgtgctatct gcagaaatca tattatggac ttatgtattg agtgtcaagc taacaccgat
       190        200        210        220        230        240
tctgctgctg ctcaagagtg cacagtggca tggggaactt gtaatcatgc atttcacttt
       250        260        270        280        290        300
cactgcatct caagatggtt aaacactagg aatgtttgtc ctttggacaa tcgtgaatgg
       310        320
gagttccaac gttatggtca ttaa   

Last modification date: Oct. 2, 2011