Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA repair protein RAD2


DESCRIPTION:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.

MISCELLANEOUS:
Present with 846 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MGVHSFWDIA GPTARPVRLE SLEDKRMAVD ASIWIYQFLK AVRDQEGNAV KNSHITGFFR
        70         80         90        100        110        120
RICKLLYFGI RPVFVFDGGV PVLKRETIRQ RKERRQGKRE SAKSTARKLL ALQLQNGSND
       130        140        150        160        170        180
NVKNSTPSSG SSVQIFKPQD EWDLPDIPGF KYDKEDARVN SNKTFEKLMN SINGDGLEDI
       190        200        210        220        230        240
DLDTINPASA EFEELPKATQ YLILSSLRLK SRLRMGYSKE QLETIFPNSM DFSRFQIDMV
       250        260        270        280        290        300
KRRNFFTQKL INTTGFQDGG ASKLNEEVIN RISGQKSKEY KLTKTNNGWI LGLGANDGSD
       310        320        330        340        350        360
AQKAIVIDDK DAGALVKQLD SNAEDGDVLR WDDLEDNSLK IVRHESSNAT TAPQKRSNRS
       370        380        390        400        410        420
EDEGCDSDEC EWEEVELKPK NVKFVEDFSL KAARLPYMGQ SLNNAGSKSF LDKRHDQASP
       430        440        450        460        470        480
SKTTPTMRIS RISVEDDDED YLKQIEEIEM MEAVQLSKME KKPEADDKSK IAKPVTSKGT
       490        500        510        520        530        540
EARPPIVQYG LLGAQPDSKQ PYHVTNLNSK SESVIKRTSK TVLSEFRPPS QQEDKGAILT
       550        560        570        580        590        600
EGEQNLNFIS HKIPQFDFNN ENSLLFQKNT ESNVSQEATK EKSPIPEMPS WFSSTASQQL
       610        620        630        640        650        660
YNPYNTTNFV EDKNVRNEQE SGAETTNKGS SYELLTGLNA TEILERESEK ESSNDENKDD
       670        680        690        700        710        720
DLEVLSEELF EDVPTKSQIS KEAEDNDSRK VESINKEHRK PLIFDYDFSE DEEDNIVENM
       730        740        750        760        770        780
IKEQEEFDTF KNTTLSTSAE RNVAENAFVE DELFEQQMKD KRDSDEVTMD MIKEVQELLS
       790        800        810        820        830        840
RFGIPYITAP MEAEAQCAEL LQLNLVDGII TDDSDVFLFG GTKIYKNMFH EKNYVEFYDA
       850        860        870        880        890        900
ESILKLLGLD RKNMIELAQL LGSDYTNGLK GMGPVSSIEV IAEFGNLKNF KDWYNNGQFD
       910        920        930        940        950        960
KRKQETENKF EKDLRKKLVN NEIILDDDFP SVMVYDAYMR PEVDHDTTPF VWGVPDLDML
       970        980        990       1000       1010       1020
RSFMKTQLGW PHEKSDEILI PLIRDVNKRK KKGKQKRINE FFPREYISGD KKLNTSKRIS
      1030
TATGKLKKRK M    

Encoded by RAD2 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgggtgtgc attcattttg ggatattgca ggtcctacgg caagaccggt caggctggaa
        70         80         90        100        110        120
tccttggaag ataagagaat ggcagtagat gcctccattt ggatatatca gtttttgaaa
       130        140        150        160        170        180
gctgtccgtg atcaggaggg gaatgcagtg aagaattctc atattactgg gttctttaga
       190        200        210        220        230        240
agaatttgta agctattata ctttggcatt aggccggtat tcgtctttga tggtggtgtg
       250        260        270        280        290        300
cccgtattga aaagggaaac aatacggcag aggaaagaaa gaagacaggg aaaacgagag
       310        320        330        340        350        360
agtgcgaaat ccaccgctag gaagctgctg gctttacaat tgcaaaacgg ctcaaacgat
       370        380        390        400        410        420
aacgtaaaaa actctacacc gagtagtggc agtagtgtgc agatcttcaa acctcaggac
       430        440        450        460        470        480
gagtgggact tgcccgatat accgggattc aaatacgata aggaagatgc aagagttaac
       490        500        510        520        530        540
tctaataaaa cttttgaaaa actgatgaat tcgataaacg gtgatggact ggaagacatt
       550        560        570        580        590        600
gatttagaca ctataaatcc agcatcggcc gaatttgaag agctgccaaa ggccacacag
       610        620        630        640        650        660
tatttgatat tatcgtcgtt gaggttgaaa tcaagactga ggatgggata ctcgaaagaa
       670        680        690        700        710        720
caattggaga ccatcttccc aaatagtatg gatttctcaa gatttcaaat agacatggtg
       730        740        750        760        770        780
aaaaggagga atttttttac tcaaaagtta atcaacacta ctgggtttca ggatggtgga
       790        800        810        820        830        840
gcgtctaagc tgaacgagga ggtgatcaat aggatatccg gccaaaagag taaagagtac
       850        860        870        880        890        900
aagttgacta agactaataa cgggtggatt cttggactag gggcaaacga tggctctgat
       910        920        930        940        950        960
gcgcaaaaag caatcgtaat agacgataaa gatgcaggcg ctttggtaaa gcagttagat
       970        980        990       1000       1010       1020
agtaatgctg aggacgggga cgtgctccga tgggatgatt tggaagataa ttccttaaaa
      1030       1040       1050       1060       1070       1080
atagtgcgac atgagtcttc taacgcgacg acagctccac agaaaaggag taaccggtca
      1090       1100       1110       1120       1130       1140
gaagatgagg gatgtgactc tgatgaatgt gagtgggaag aagttgaact caagcccaag
      1150       1160       1170       1180       1190       1200
aacgtcaagt ttgtggaaga tttttctttg aaagctgcaa ggttgcctta catgggccaa
      1210       1220       1230       1240       1250       1260
tccctaaaca acgctggcag taaatcgttt ttggacaaaa gacatgatca ggcatcgccc
      1270       1280       1290       1300       1310       1320
tccaagacta ctccaacaat gagaattagc agaatcagcg tggaagacga cgatgaggat
      1330       1340       1350       1360       1370       1380
tacctgaaac aaattgagga aattgaaatg atggaggcag tgcaactttc taagatggaa
      1390       1400       1410       1420       1430       1440
aagaaacctg aagcggacga caaatcaaaa atcgctaagc cggtaacgtc aaaaggtaca
      1450       1460       1470       1480       1490       1500
gaggctcgtc caccaatagt acagtatgga ttacttggcg cacaaccgga tagtaagcaa
      1510       1520       1530       1540       1550       1560
ccgtatcatg tcacaaattt gaatagcaaa tcagagtcgg tcatcaaaag gaccagcaag
      1570       1580       1590       1600       1610       1620
acagttcttt ctgagtttag gccaccgtct cagcaggagg ataaaggggc tattttaaca
      1630       1640       1650       1660       1670       1680
gagggggagc aaaacctgaa ttttatttct cacaagatac cacagtttga ttttaacaat
      1690       1700       1710       1720       1730       1740
gaaaattccc tgctttttca aaagaatacc gagagtaatg tgtcccaaga agccacgaag
      1750       1760       1770       1780       1790       1800
gaaaagtctc caattcctga aatgccgagc tggttttctt caactgcttc ccagcagttg
      1810       1820       1830       1840       1850       1860
tataatccct ataacacaac aaatttcgtg gaagataaaa acgtaagaaa tgaacaagaa
      1870       1880       1890       1900       1910       1920
agtggagcag aaactaccaa taaagggagt agctatgaac tcttgacagg cttaaatgct
      1930       1940       1950       1960       1970       1980
acggaaatat tagaaagaga aagcgagaaa gagagctcca atgatgaaaa caaggacgat
      1990       2000       2010       2020       2030       2040
gacttagaag ttttatcaga agaactattt gaggacgttc ccactaaatc tcagatttca
      2050       2060       2070       2080       2090       2100
aaagaagcag aggataacga tagtagaaaa gtcgaatcta taaataagga gcatagaaag
      2110       2120       2130       2140       2150       2160
cctcttatat tcgactatga cttctccgaa gatgaagaag ataacatagt agaaaatatg
      2170       2180       2190       2200       2210       2220
ataaaggaac aagaagagtt tgatacattt aaaaacacga ctttgtccac ttctgctgaa
      2230       2240       2250       2260       2270       2280
agaaacgttg ccgagaacgc ttttgtggag gatgaattat tcgaacaaca gatgaaggat
      2290       2300       2310       2320       2330       2340
aaaagagatt cggatgaggt aactatggat atgatcaaag aagtgcaaga attactatcg
      2350       2360       2370       2380       2390       2400
aggtttggaa tcccctatat cactgcgcct atggaagctg aagcacagtg tgcggaattg
      2410       2420       2430       2440       2450       2460
ttacaactaa accttgtcga tggtataatt accgatgaca gtgatgtttt cctatttgga
      2470       2480       2490       2500       2510       2520
ggtacaaaga tctacaaaaa tatgttccac gaaaagaact atgttgaatt ttatgatgcg
      2530       2540       2550       2560       2570       2580
gaatctattt taaaattatt gggcttggat agaaagaata tgattgagtt ggcacagctt
      2590       2600       2610       2620       2630       2640
ttagggagcg attacacgaa tggattgaag ggtatgggtc ccgtttcaag cattgaagtg
      2650       2660       2670       2680       2690       2700
attgcagaat ttggaaacct aaaaaatttt aaagactggt ataataatgg gcagtttgat
      2710       2720       2730       2740       2750       2760
aaacgtaagc aagaaacgga aaataaattt gaaaaagacc tgagaaaaaa actggtaaat
      2770       2780       2790       2800       2810       2820
aacgaaatta tcttagatga tgattttcct agcgtcatgg tttatgatgc gtatatgaga
      2830       2840       2850       2860       2870       2880
ccagaagtcg atcacgatac cacgccgttt gtttgggggg taccagatct cgatatgctt
      2890       2900       2910       2920       2930       2940
cgttcattca tgaagactca actaggttgg ccacacgaaa agtctgatga aattctcatt
      2950       2960       2970       2980       2990       3000
cccttaatta gagatgttaa taaacgcaaa aagaagggga agcaaaaaag gattaatgaa
      3010       3020       3030       3040       3050       3060
ttttttccaa gggagtacat atctggtgat aagaagctca atacaagtaa gagaatttca
      3070       3080       3090
accgcaacag gtaaactaaa gaaaagaaag atgtaa  

Last modification date: Oct. 2, 2011