Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: RNA polymerase II transcription factor B subunit 4


DESCRIPTION:
Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.

STRUCTURE SIMILARITY:
Belongs to the TFB4 family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MDAISDPTFK HARSRKQVTE ESPSLLTVII EIAPKLWTTF DEEGNEKGSI IKVLEALIVF
        70         80         90        100        110        120
LNAHLAFNSA NKVAVIAAYS QGIKYLYPES TSALKASESE NKTRSDLKII NSDMYRRFRN
       130        140        150        160        170        180
VDETLVEEIY KLFELEKKQI EQNSQRSTLA GAMSAGLTYV NRISKESVTT SLKSRLLVLT
       190        200        210        220        230        240
CGSGSSKDEI FQYIPIMNCI FSATKMKCPI DVVKIGGSKE STFLQQTTDA TNGVYLHVES
       250        260        270        280        290        300
TEGLIQYLAT AMFIDPSLRP IIVKPNHGSV DFRTSCYLTG RVVAVGFICS VCLCVLSIIP
       310        320        330
PGNKCPACDS QFDEHVIAKL KRKPVVPRLK AKKKVTKP  

Encoded by TFB4 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggatgcaa tatctgatcc aacgtttaag catgctagat caagaaaaca ggttactgaa
        70         80         90        100        110        120
gaatcaccat ctttgcttac cgttattata gaaattgcac caaagttatg gacaactttt
       130        140        150        160        170        180
gatgaggaag gaaatgagaa aggaagtata ataaaggttt tagaggcatt gatagtattt
       190        200        210        220        230        240
ctcaatgctc acttagcgtt caatagcgcc aacaaagtag cagtcattgc tgcatactct
       250        260        270        280        290        300
cagggaatca aatatttata cccagagagc acatctgctc taaaagcctc tgaatctgaa
       310        320        330        340        350        360
aataaaaccc gtagtgatct taagattatt aactcagata tgtatagacg ttttagaaac
       370        380        390        400        410        420
gttgatgaga cgctagtgga agaaatatat aaactatttg agttagaaaa gaaacaaatc
       430        440        450        460        470        480
gaacaaaata gtcaaaggag cacgctagca ggtgccatgt cagctgggct gacttatgta
       490        500        510        520        530        540
aacagaatat caaaagagtc agtaactacc tcattaaaat caaggctact tgttcttacg
       550        560        570        580        590        600
tgcgggagtg gcagtagtaa agatgaaatt ttccaataca tccctataat gaactgtatt
       610        620        630        640        650        660
ttttccgcaa caaaaatgaa atgtcccatt gatgtcgtaa agattggtgg ttctaaggaa
       670        680        690        700        710        720
agcacgtttt tacagcaaac gacggatgcc acaaatggcg tttatttaca tgttgaatct
       730        740        750        760        770        780
acagaagggc taattcaata tttagcaact gcaatgttta ttgatccgtc gttaagacct
       790        800        810        820        830        840
ataattgtta agccaaacca tggatctgta gattttagga catcatgcta tttaacaggg
       850        860        870        880        890        900
agagttgttg ccgttggatt catctgttca gtttgcctat gtgtcttatc aatcataccg
       910        920        930        940        950        960
cccggaaata aatgtcctgc ttgtgattct caatttgatg agcacgtaat tgccaagttg
       970        980        990       1000       1010
aagaggaaac cagttgttcc aaggttgaaa gccaaaaaga aggtgacgaa accatga

Last modification date: Oct. 2, 2011