Homo sapiens L. (human) [HSA]

FULL NAME: DNA ligase 1


DESCRIPTION:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


PROTEIN TYPE(S):
DNA ligase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA
        70         80         90        100        110        120
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK
       130        140        150        160        170        180
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEEETP KESLTEAEVA TEKEGEDGDQ
       190        200        210        220        230        240
PTTPPKPLKT SKAETPTESV SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK
       250        260        270        280        290        300
KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE
       310        320        330        340        350        360
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ
       370        380        390        400        410        420
ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT ASGVFSKFRD IARLTGSAST
       430        440        450        460        470        480
AKKIDIIKGL FVACRHSEAR FIARSLSGRL RLGLAEQSVL AALSQAVSLT PPGQEFPPAM
       490        500        510        520        530        540
VDAGKGKTAE ARKTWLEEQG MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL
       550        560        570        580        590        600
KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD
       610        620        630        640        650        660
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE IQVQVCLYAF
       670        680        690        700        710        720
DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD TKDIEQIAEF LEQSVKDSCE
       730        740        750        760        770        780
GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL
       790        800        810        820        830        840
ASYDEDSEEL QAICKLGTGF SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA
       850        860        870        880        890        900
VWEVKCADLS LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ
       910
SQIQNQQGED SGSDPEDTY    

Encoded by LIG1 gene

FULL NAME: ligase I, DNA, ATP-dependent


OTHER NAME(S):
MGC117397
MGC130025


DESCRIPTION:
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgcagcgaa gtatcatgtc atttttccac cccaagaaag agggtaaagc aaagaagcct
        70         80         90        100        110        120
gagaaggagg catccaatag cagcagagag acggagcccc ctccaaaggc ggcactgaag
       130        140        150        160        170        180
gagtggaatg gagtggtgtc cgagagtgac tctccggtga agaggccagg gaggaaggcg
       190        200        210        220        230        240
gcccgggtcc tgggcagcga aggggaagag gaggatgaag cccttagccc tgctaaaggc
       250        260        270        280        290        300
cagaagcctg ccctggactg ctcacaggtc tccccgcccc gtcctgccac atctcctgag
       310        320        330        340        350        360
aacaatgctt ccctctctga cacctctccc atggacagtt ccccatcagg gattccgaag
       370        380        390        400        410        420
cgtcgcacag ctcggaagca gctcccgaaa cggaccattc aggaagtcct ggaagagcag
       430        440        450        460        470        480
agtgaggacg aggacagaga agccaagagg aagaaggagg aggaagaaga ggagaccccg
       490        500        510        520        530        540
aaagaaagcc tcacagaggc tgaagtggca acagagaagg aaggagaaga cggggaccag
       550        560        570        580        590        600
cccaccacgc ctcccaagcc cctaaagacc tccaaagcag agaccccgac ggaaagcgtt
       610        620        630        640        650        660
tcagagcctg aggtggccac gaagcaggaa ctgcaggagg aggaagagca gaccaagcct
       670        680        690        700        710        720
ccccgcagag ctcccaagac gctcagcagc ttcttcaccc cccggaagcc agcagtcaaa
       730        740        750        760        770        780
aaagaagtga aggaagagga gccaggggct ccaggaaagg agggagctgc tgagggaccc
       790        800        810        820        830        840
ctggatccat ctggttacaa tcctgccaag aacaactatc atcccgtgga agatgcctgc
       850        860        870        880        890        900
tggaaaccgg gccagaaggt tccttacctg gctgtggccc ggacgtttga gaagatcgag
       910        920        930        940        950        960
gaggtgtctg ctcggctccg gatggtggag acgctgagca acttgctgcg ctccgtggtg
       970        980        990       1000       1010       1020
gccctgtcgc ctccagacct cctccctgtc ctctacctca gcctcaacca ccttgggcca
      1030       1040       1050       1060       1070       1080
ccccagcagg gcctggagct tggcgtgggt gatggtgtcc ttctcaaggc agtggcccag
      1090       1100       1110       1120       1130       1140
gccacaggtc ggcagctgga gtccgtccgg gctgaggcag ccgagaaagg cgacgtgggg
      1150       1160       1170       1180       1190       1200
ctggtggccg agaacagccg cagcacccag aggctcatgc tgccaccacc tccgctcact
      1210       1220       1230       1240       1250       1260
gcctccgggg tcttcagcaa gttccgcgac atcgccaggc tcactggcag tgcttccaca
      1270       1280       1290       1300       1310       1320
gccaagaaga tagacatcat caaaggcctc tttgtggcct gccgccactc agaagcccgg
      1330       1340       1350       1360       1370       1380
ttcatcgcta ggtccctgag cggacggctg cgccttgggc tggcagagca gtcggtgctg
      1390       1400       1410       1420       1430       1440
gctgccctct cccaggcagt gagcctcacg cccccgggcc aagaattccc accagccatg
      1450       1460       1470       1480       1490       1500
gtggatgctg ggaagggcaa gacagcagag gccagaaaga cgtggctgga ggagcaaggc
      1510       1520       1530       1540       1550       1560
atgatcctga agcagacgtt ctgcgaggtt cccgacctgg accgaattat ccccgtgctg
      1570       1580       1590       1600       1610       1620
ctggagcacg gcctggaacg tctcccggag cactgcaagc tgagcccagg gattcccctg
      1630       1640       1650       1660       1670       1680
aaaccaatgt tggcccatcc cacccggggc atcagcgagg tcctgaaacg ctttgaggag
      1690       1700       1710       1720       1730       1740
gcagctttca cctgcgaata caaatatgac gggcagaggg cacagatcca cgccctggaa
      1750       1760       1770       1780       1790       1800
ggcggggagg tgaagatctt cagcaggaat caggaagaca acactgggaa gtacccggac
      1810       1820       1830       1840       1850       1860
atcatcagcc gcatccccaa gattaaactc ccatcggtca catccttcat cctggacacc
      1870       1880       1890       1900       1910       1920
gaagccgtgg cttgggaccg ggaaaagaag cagatccagc cattccaagt gctcaccacc
      1930       1940       1950       1960       1970       1980
cgcaaacgca aggaggtgga tgcgtctgag atccaggtgc aggtgtgttt gtacgccttc
      1990       2000       2010       2020       2030       2040
gacctcatct acctcaatgg agagtccctg gtacgtgagc ccctttcccg gcgccggcag
      2050       2060       2070       2080       2090       2100
ctgctccggg agaactttgt ggagacagag ggcgagtttg tcttcgccac ctccctggac
      2110       2120       2130       2140       2150       2160
accaaggaca tcgagcagat cgccgagttc ctggagcagt cagtgaaaga ctcctgcgag
      2170       2180       2190       2200       2210       2220
gggctgatgg tgaagaccct ggatgttgat gccacctacg agatcgccaa gagatcgcac
      2230       2240       2250       2260       2270       2280
aactggctca agctgaagaa ggactacctt gatggcgtgg gtgacaccct ggacctggtg
      2290       2300       2310       2320       2330       2340
gtgatcggcg cctacctggg ccgggggaag cgggccggcc ggtacggggg cttcctgctg
      2350       2360       2370       2380       2390       2400
gcctcctacg acgaggacag tgaggagctg caggccatat gcaagcttgg aactggcttc
      2410       2420       2430       2440       2450       2460
agtgatgagg agctggagga gcatcaccag agcctcaagg cgctggtgct gcccagccca
      2470       2480       2490       2500       2510       2520
cgcccttacg tgcggataga tggcgctgtg attcccgacc actggctgga ccccagcgct
      2530       2540       2550       2560       2570       2580
gtgtgggagg tgaagtgcgc tgacctctcc ctctctccca tctaccctgc tgcgcggggc
      2590       2600       2610       2620       2630       2640
ctggtggata gtgacaaggg catctccctt cgcttccctc ggtttattcg agtccgtgaa
      2650       2660       2670       2680       2690       2700
gacaagcagc cggagcaggc caccaccagt gctcaggtgg cctgtttgta ccggaagcaa
      2710       2720       2730       2740       2750       2760
agtcagattc agaaccaaca aggcgaggac tcaggctctg accctgaaga tacctactaa

Last modification date: Oct. 2, 2011