Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: RNA polymerase II transcription factor B subunit 1


DESCRIPTION:
Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.

MISCELLANEOUS:
Present with 5150 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Contains 2 BSD domains.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MSHSGAAIFE KVSGIIAINE DVSPAELTWR STDGDKVHTV VLSTIDKLQA TPASSEKMML
        70         80         90        100        110        120
RLIGKVDESK KRKDNEGNEV VPKPQRHMFS FNNRTVMDNI KMTLQQIISR YKDADIYEEK
       130        140        150        160        170        180
RRREESAQHT ETPMSSSSVT AGTPTPHLDT PQLNNGAPLI NTAKLDDSLS KEKLLTNLKL
       190        200        210        220        230        240
QQSLLKGNKV LMKVFQETVI NAGLPPSEFW STRIPLLRAF ALSTSQKVGP YNVLSTIKPV
       250        260        270        280        290        300
ASSENKVNVN LSREKILNIF ENYPIVKKAY TDNVPKNFKE PEFWARFFSS KLFRKLRGEK
       310        320        330        340        350        360
IMQNDRGDVI IDRYLTLDQE FDRKDDDMLL HPVKKIIDLD GNIQDDPVVR GNRPDFTMQP
       370        380        390        400        410        420
GVDINGNSDG TVDILKGMNR LSEKMIMALK NEYSRTNLQN KSNITNDEED EDNDERNELK
       430        440        450        460        470        480
IDDLNESYKT NYAIIHLKRN AHEKTTDNDA KSSADSIKNA DLKVSNQQML QQLSLVMDNL
       490        500        510        520        530        540
INKLDLNQVV PNNEVSNKIN KRVITAIKIN AKQAKHNNVN SALGSFVDNT SQANELEVKS
       550        560        570        580        590        600
TLPIDLLESC RMLHTTCCEF LKHFYIHFQS GEQKQASTVK KLYNHLKDCI EKLNELFQDV
       610        620        630        640
LNGDGESMSN TCTAYLKPVL NSITLATHKY DEYFNEYNNN SN 

Encoded by TFB1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcacatt ccggagctgc catttttgag aaagtttctg ggataattgc cataaatgag
        70         80         90        100        110        120
gatgtttcac ccgcagaatt gacatggagg tctacggacg gtgacaaggt tcacacagtt
       130        140        150        160        170        180
gtcttatcca ctattgacaa gttacaagct acccctgctt ccagtgaaaa aatgatgttg
       190        200        210        220        230        240
aggctaatcg ggaaagtgga tgagtcaaaa aagagaaaag acaacgaagg aaatgaggtt
       250        260        270        280        290        300
gtgcccaaac cgcaacgtca tatgttttcg tttaacaata gaacagttat ggataatatc
       310        320        330        340        350        360
aagatgaccc ttcaacaaat catctcacgg tataaagatg cagatatcta cgaagaaaag
       370        380        390        400        410        420
agaagaagag aggagtctgc gcaacacaca gaaacaccaa tgagctcttc ttctgttact
       430        440        450        460        470        480
gcagggactc ccacaccaca tctcgataca ccacaattga ataatggggc tccgttgatt
       490        500        510        520        530        540
aatacagcca aactagatga ttctctctct aaagaaaaat tgttgaccaa tttaaagcta
       550        560        570        580        590        600
cagcaatctt tactgaaagg aaacaaagtt ctaatgaagg tttttcagga aacagtcatt
       610        620        630        640        650        660
aacgccggtt tgcctccatc tgaattttgg tcaactagaa ttccgttatt gagggctttt
       670        680        690        700        710        720
gccttatcta cttctcaaaa agttgggcct tacaacgttt tgtcaactat caagccggtg
       730        740        750        760        770        780
gcttcatcgg aaaacaaagt caatgttaat ttgtcaagag aaaaaatttt gaatattttt
       790        800        810        820        830        840
gagaactatc caattgtaaa gaaagcttac actgataatg tgcccaaaaa tttcaaagaa
       850        860        870        880        890        900
ccagagttct gggcaaggtt cttctcttcg aagttattca gaaaattaag gggtgaaaag
       910        920        930        940        950        960
atcatgcaaa atgatagagg tgacgtaatc attgacaggt acttgacatt ggatcaagag
       970        980        990       1000       1010       1020
ttcgacagaa aagatgatga catgctattg catcctgtga aaaaaattat agatttagat
      1030       1040       1050       1060       1070       1080
ggtaacatac aggacgaccc agttgtacga ggcaacaggc ccgacttcac tatgcagcca
      1090       1100       1110       1120       1130       1140
ggtgtggata ttaatggtaa tagcgatggt accgtggaca tcttaaaggg tatgaataga
      1150       1160       1170       1180       1190       1200
ttgagtgaaa aaatgattat ggctttgaag aatgagtatt caaggacaaa tctacagaac
      1210       1220       1230       1240       1250       1260
aaatctaata ttacaaacga tgaggaagat gaagataatg atgaaagaaa tgaactgaaa
      1270       1280       1290       1300       1310       1320
atcgatgact taaacgaaag ctacaagaca aactatgcaa tcatacatct gaaaaggaac
      1330       1340       1350       1360       1370       1380
gcacatgaaa agacaaccga caacgatgcg aaaagctcgg cagactcgat aaagaatgca
      1390       1400       1410       1420       1430       1440
gatttgaagg tttctaatca acaaatgtta caacagttgt cattggtcat ggataattta
      1450       1460       1470       1480       1490       1500
attaataagc tagacttgaa ccaagtagtt cctaacaacg aagtcagcaa caagatcaat
      1510       1520       1530       1540       1550       1560
aaaagagtca taactgcaat caagattaac gccaaacagg ctaagcataa caatgttaat
      1570       1580       1590       1600       1610       1620
tcagcactcg gctcttttgt cgacaacact tctcaagcaa atgaattaga ggtgaaaagt
      1630       1640       1650       1660       1670       1680
accctaccaa tagacctatt agaaagttgt agaatgctac acacaacgtg ctgtgaattt
      1690       1700       1710       1720       1730       1740
ctaaagcact tttatattca ttttcagagc ggtgaacaaa agcaagccag taccgtcaaa
      1750       1760       1770       1780       1790       1800
aaactttata atcatttgaa ggactgtatt gaaaagctga atgagctatt tcaagacgtc
      1810       1820       1830       1840       1850       1860
cttaatggtg atggtgaatc tatgtcaaac acatgtaccg cctatttgaa gccagttttg
      1870       1880       1890       1900       1910       1920
aactccatta ctttggctac tcataagtac gatgagtact tcaacgaata taacaacaat

tcgaactag     

Last modification date: Oct. 2, 2011