Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: Regulator of telomere elongation helicase 1 homolog


DESCRIPTION:
ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates (By similarity).

STRUCTURE SIMILARITY:
Belongs to the helicase family. RAD3/XPD subfamily.
Contains 1 helicase ATP-binding domain.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
telomere maintenance


Amino acids sequence

        10         20         30         40         50         60
MPESLIAGIP VHFPFEPYPV QRAYMEKVIH CLRDGTNGVL ESPTGTGKTL SLLCSSLAWI
        70         80         90        100        110        120
RTRQSEHQKQ MVKMEKADFS GLGGGAPGGD LSELAKTMGR ANNWGVPKVI YASRTHSQLT
       130        140        150        160        170        180
QAMRELKRTA YANMRSVVLG SRDQLCIHPE VMREQGNSNK TNMCKLRVHS KTCSFQMRVE
       190        200        210        220        230        240
SRKDHPDLRG PTIMDIEDLV KVGQRLKICP YFASRELVPQ ADITFMPYNY LLDPKARKAN
       250        260        270        280        290        300
KIELGNTIVI LDEAHNIEKI CEESASVQIK SSDVAMAIED VTHIMQVFAS GESQDMAGDE
       310        320        330        340        350        360
PKDFTLDDLT LLKEMLLELE KAIDAIVVDN AVDGTTFPAS MMYELLGKAN FTYGNVATIV
       370        380        390        400        410        420
SLLDKLVQYL LVASQQMSIR KGGTFTLLSD LLTIVFANKE DVMSKVYASF KVHVLVEESK
       430        440        450        460        470        480
QGHGKQQGAK QQGGWLGKGT IAAATGLSKV AKIINFWCFN PGFGMEQLLN TQVRSVILTS
       490        500        510        520        530        540
GTLAPLKPLI AELAIPVAQH LENPHIVDQS QVYVKIIGTG PDRQQLISNY ANRDNPKYIS
       550        560        570        580        590        600
SLGQTILNVA RIVPDGLLVF FPSYPMLNKC VDAWQASGLW ADISCKKPIF LEPRSKDQFT
       610        620        630        640        650        660
STMEEFYQAI RDSKGAVFMA VCRGKVSEGL DFADRNGRAV IITGLPFPPL KDPKVILKRR
       670        680        690        700        710        720
YLEANRTREN QLLSGQEWYN LDATRAVNQA IGRVIRHRND YGAILLCDSR FKDASQVQQL
       730        740        750        760        770        780
SKWIRGHLGD RPQCSPFGPI VRELRQFFKN AEANMKLPDE RETDSPLETV CKTEDEPLAA
       790        800        810        820        830        840
IPKVKREPGS NATFKSANES AIKVEMANSI KTWTPADYAS AAGHKLGGAA PNAMDFMSRL
       850        860        870        880        890        900
DSNVSSIDFN CCTDSKSGSS GLVKIHKRER SSPTAPESSS QVTKKRYKLV ENIKVEPSSS
       910        920        930        940        950        960
QAKEAPEERA AFLRELRSLV TQDQFRRFGK ALLEYKNGTY ESFQALMAIL LDVLSAPKVR
       970        980
YMLVGMRKYL KNEHKDEFDR RVGNL   

Encoded by CG4078 gene


OTHER NAME(S):
Dmel\CG4078


Nucleic acid sequence

        10         20         30         40         50         60
atgccggaga gcctgatcgc cggcattccg gtgcactttc cgttcgagcc gtacccggtt
        70         80         90        100        110        120
caacgggcgt acatggagaa ggtgatccat tgtctccgcg atggcacgaa tggagtcctg
       130        140        150        160        170        180
gaatcgccaa ccggcacggg caagacccta agcttgctgt gctcatcctt ggcctggatc
       190        200        210        220        230        240
cgcaccaggc aatcggagca ccaaaagcag atggttaaga tggagaaggc agatttttcg
       250        260        270        280        290        300
ggtcttggag gcggagcacc tgggggagac ctgtccgagc tggccaagac catgggtcgt
       310        320        330        340        350        360
gcgaataact ggggcgtgcc caaggtcatc tacgcctcgc gcacccactc ccaattgacg
       370        380        390        400        410        420
caggcgatgc gggaactcaa gaggacagcg tacgctaaca tgagatccgt ggttctgggc
       430        440        450        460        470        480
tcccgcgatc agctatgcat tcatccggag gtcatgcggg agcagggcaa ctccaacaag
       490        500        510        520        530        540
accaacatgt gcaagctacg ggtgcactcc aagacctgtt catttcaaat gcgcgttgag
       550        560        570        580        590        600
tcgcgaaagg atcatcccga tttgcgcgga cccaccatca tggacattga ggacctggtc
       610        620        630        640        650        660
aaggtgggcc agcgactcaa gatctgtccc tacttcgcgt ctcgggagtt ggttccccag
       670        680        690        700        710        720
gcggatatca ccttcatgcc ctacaattat ctactcgatc ccaaggctcg caaggccaac
       730        740        750        760        770        780
aaaatcgaac tgggcaacac tattgtgatc ctggatgagg cccacaacat cgagaagatc
       790        800        810        820        830        840
tgcgaggagt ccgcttcggt gcagattaag tcctctgatg tggccatggc catcgaggac
       850        860        870        880        890        900
gtcacgcata tcatgcaagt ctttgcgagc ggcgagtcgc aggatatggc tggagatgag
       910        920        930        940        950        960
ccaaaggact tcacactgga cgaccttaca ctgctcaagg agatgctgct cgagctcgaa
       970        980        990       1000       1010       1020
aaggccatcg atgccatcgt tgtggacaac gccgtcgatg gaactacctt tcccgcctcc
      1030       1040       1050       1060       1070       1080
atgatgtacg aactgcttgg caaggcgaat ttcacctacg gcaacgttgc aacgatagta
      1090       1100       1110       1120       1130       1140
tccctgctgg acaaactggt gcaatacctc ctagtggcct cccagcagat gagcatccgc
      1150       1160       1170       1180       1190       1200
aagggcggca ccttcacgtt gcttagcgat ctactgacca ttgtgtttgc caacaaggag
      1210       1220       1230       1240       1250       1260
gatgtgatga gcaaggtgta cgcaagcttc aaagtgcatg tcctggtgga ggagtccaag
      1270       1280       1290       1300       1310       1320
cagggacacg gtaagcagca gggtgctaaa cagcagggcg gttggcttgg caagggaacg
      1330       1340       1350       1360       1370       1380
attgcagcag cgactggctt aagcaaggtc gcaaaaatca ttaacttctg gtgcttcaat
      1390       1400       1410       1420       1430       1440
cctggcttcg gaatggagca actgctcaac acccaagtgc gcagcgtaat cctgaccagc
      1450       1460       1470       1480       1490       1500
ggcacactag ctcccctcaa gccgctaatc gccgagcttg ccattccggt ggcccagcat
      1510       1520       1530       1540       1550       1560
ctggagaatc cgcacatcgt cgaccagtcg caggtttatg tcaagatcat cggcaccgga
      1570       1580       1590       1600       1610       1620
cccgatcggc agcaactgat atcgaactat gcgaaccgtg ataatccaaa gtacatcagc
      1630       1640       1650       1660       1670       1680
tccctgggac agacgattct gaatgtagcg cgtatagtgc ccgacggcct ccttgtcttt
      1690       1700       1710       1720       1730       1740
ttcccatcgt atcccatgtt gaacaagtgc gtggacgcgt ggcaggccag tggtttgtgg
      1750       1760       1770       1780       1790       1800
gcggacatat cgtgcaagaa accgattttt ctggagccgc gcagcaagga ccagttcacc
      1810       1820       1830       1840       1850       1860
agcacgatgg aagagttcta ccaggcgata cgcgactcca agggtgccgt attcatggct
      1870       1880       1890       1900       1910       1920
gtttgtcgcg gcaaagtctc cgaaggtctg gactttgctg atcgcaatgg ccgcgcggtg
      1930       1940       1950       1960       1970       1980
attattactg gtctgccatt cccaccgcta aaggatccca aggtgatact gaaacgtcgc
      1990       2000       2010       2020       2030       2040
tacctggagg cgaatcggac tcgtgagaat cagctgttaa gtgggcagga atggtacaat
      2050       2060       2070       2080       2090       2100
ctagatgcca cgagggcagt caatcaagcc atcggtcgtg tgattcggca tcgcaacgat
      2110       2120       2130       2140       2150       2160
tatggtgcca ttctgctttg cgactcgcga tttaaggacg cctcacaggt ccagcagcta
      2170       2180       2190       2200       2210       2220
tccaaatgga ttcggggtca cctgggcgac cggccacagt gctcaccctt tggtcctatc
      2230       2240       2250       2260       2270       2280
gtccgggaac tgcgtcagtt ctttaagaac gccgaagcga atatgaaact accggatgaa
      2290       2300       2310       2320       2330       2340
agggaaaccg attcgccttt ggaaaccgtc tgcaagacag aggatgaacc actagccgcc
      2350       2360       2370       2380       2390       2400
attccaaaag tgaaacggga gcctggctcc aatgccacct tcaaatcagc caatgaatcc
      2410       2420       2430       2440       2450       2460
gcaatcaaag tggagatggc caattccatc aagacatgga cacccgccga ttatgcgagt
      2470       2480       2490       2500       2510       2520
gccgctggac ataaattggg tggtgcggcg ccgaatgcca tggactttat gagtcgactg
      2530       2540       2550       2560       2570       2580
gactcaaatg tctcgagtat cgatttcaac tgctgcacag atagtaaaag tggctcctct
      2590       2600       2610       2620       2630       2640
ggtctggtga agattcacaa gcgggagcga agctcaccaa cggcgccgga atcctccagc
      2650       2660       2670       2680       2690       2700
caggtgacca aaaagcgata caagttggtg gagaacatca aggtggagcc aagtagttcg
      2710       2720       2730       2740       2750       2760
caggctaagg aggcacccga ggaaagggcc gcgtttctcc gggagctacg cagcctggtc
      2770       2780       2790       2800       2810       2820
acccaagatc aattccgccg ctttggcaag gcgctgctgg agtacaagaa tggcacctat
      2830       2840       2850       2860       2870       2880
gagagctttc aggccctgat ggccatactc ctggatgtcc tgtccgcacc caaagtgcgc
      2890       2900       2910       2920       2930       2940
tacatgctcg tcgggatgcg gaagtatcta aagaacgagc acaaggacga gtttgatcgt
      2950
agggtgggca atctttaa    

Last modification date: Oct. 2, 2011