Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: Cyclin CCL1


DESCRIPTION:
Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.

MISCELLANEOUS:
Present with 8700 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the cyclin family. Cyclin C subfamily.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MTDIQLNGKS TLDTPSATMS AKEKEAKLKS ADENNKPPNY KRISDDDLYR HSSQYRMWSY
        70         80         90        100        110        120
TKDQLQEKRV DTNARAIAYI EENLLKFREA HNLTEEEIKV LEAKAIPLTM EEELDLVNFY
       130        140        150        160        170        180
AKKVQVIAQH LNLPTEVVAT AISFFRRFFL ENSVMQIDPK SIVHTTIFLA CKSENYFISV
       190        200        210        220        230        240
DSFAQKAKST RDSVLKFEFK LLESLKFSLL NHHPYKPLHG FFLDIQNVLY GKVDLNYMGQ
       250        260        270        280        290        300
IYDRCKKRIT AALLTDVVYF YTPPQITLAT LLIEDEALVT RYLETKFPSR EGSQESVPGN
       310        320        330        340        350        360
EKEEPQNDAS TTEKNKEKST ESEEYSIDSA KLLTIIRECK SIIEDCKPPS TEEAKKIAAK
       370        380        390
NYYCQNPSTL IQKLKRKLNG EDTSSTVEKK QKT  

Encoded by CCL1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgacggata ttcaactaaa tggaaagagt acattagata ctccttctgc taccatgtca
        70         80         90        100        110        120
gcaaaagaaa aagaggcaaa attaaaatcg gctgatgaga ataacaagcc accgaactac
       130        140        150        160        170        180
aaaagaattt ctgacgatga tttatatagg cactcttctc agtatagaat gtggtcatac
       190        200        210        220        230        240
actaaagatc aacttcagga gaaaagggta gataccaatg cccgagcgat tgcttacatt
       250        260        270        280        290        300
gaggaaaatt tattaaaatt tagagaagca cacaatttaa cagaagaaga aataaaagta
       310        320        330        340        350        360
ctagaagcaa aggctatccc tttgacaatg gaagaagaac tcgatttggt gaatttctac
       370        380        390        400        410        420
gcaaaaaaag ttcaggtaat agcacagcat ctaaatttgc caaccgaagt agtggccact
       430        440        450        460        470        480
gcgatatcct tttttaggcg ttttttctta gaaaattctg ttatgcaaat agatcctaaa
       490        500        510        520        530        540
agtattgtac atactactat ctttctagcc tgcaaatcgg agaactattt tattagcgtg
       550        560        570        580        590        600
gactcgtttg ctcaaaaggc caaatctact agagatagtg ttctcaaatt cgagtttaag
       610        620        630        640        650        660
ttgttagaat cattgaaatt ttcactgttg aaccatcatc cttacaaacc gcttcatggg
       670        680        690        700        710        720
tttttcttag atatccagaa cgtcctttat ggtaaggttg atttaaatta catgggccaa
       730        740        750        760        770        780
atatacgata ggtgtaagaa gagaataact gccgcattat taaccgatgt cgtatatttc
       790        800        810        820        830        840
tacactccac cccaaataac actagcaaca ttattgattg aggatgaagc cttggtcaca
       850        860        870        880        890        900
aggtatttag aaacaaaatt tcccagcaga gaaggtagcc aggaatcagt accgggaaac
       910        920        930        940        950        960
gaaaaagaag aaccacaaaa tgatgccagt acaactgaga aaaacaaaga gaagtccaca
       970        980        990       1000       1010       1020
gagagcgaag aatattcgat agactccgcg aagttactaa ccataatacg cgagtgtaaa
      1030       1040       1050       1060       1070       1080
agtattattg aagattgtaa acctccgagt actgaagagg ccaagaaaat tgcggcaaaa
      1090       1100       1110       1120       1130       1140
aactattatt gtcaaaatcc atcaacactg attcagaaat taaaaaggaa gttgaatgga
      1150       1160       1170       1180
gaagatactt cgtccaccgt tgagaaaaag caaaaaacat ga 

Last modification date: Oct. 2, 2011