Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA-directed RNA polymerase II subunit RPB7


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).

STRUCTURE SIMILARITY:
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MFFHIVLERN MQLHPRFFGR NLKENLVSKL MKDVEGTCSG RHGFVVAITG IDTIGKGLIR
        70         80         90        100        110        120
DGTGFVTFPV KYQCVVFRPF KGEILEAVVT LVNKMGFFAE AGPVQIFVSK HLIPDDMEFQ
       130        140        150        160        170
AGDMPNYTTS DGSVKIQKEC EVRLKIIGTR VDATAIFCVG TIKDDFLGVI NDPAAA

Encoded by NRPB7 gene


OTHER NAME(S):
MNC17.16
MNC17_16
NRPB7


Nucleic acid sequence

        10         20         30         40         50         60
atgtttttcc acatagtatt ggagcggaac atgcagttgc atcctcgttt ctttggtcgt
        70         80         90        100        110        120
aacctaaaag aaaacctcgt atctaagctc atgaaagatg tcgaaggcac ttgcagtggc
       130        140        150        160        170        180
cgacatggat ttgtagtggc gataactgga atagatacaa taggaaaggg tttgatcaga
       190        200        210        220        230        240
gatgggactg gttttgtcac ctttccagtt aaataccaat gcgtcgtttt cagacctttc
       250        260        270        280        290        300
aaaggcgaga ttttggaagc tgttgtcact ttggtcaata agatgggatt cttcgctgaa
       310        320        330        340        350        360
gctggccctg ttcagatttt tgtgtctaag catttgattc cagatgatat ggagtttcaa
       370        380        390        400        410        420
gctggagaca tgcctaacta taccacatca gatggatcag ttaagatcca gaaggagtgt
       430        440        450        460        470        480
gaagtgagac taaagattat tggaacaaga gttgatgcca ctgcgatttt ttgtgtgggt
       490        500        510        520        530
accatcaaag acgatttttt gggagtcata aacgaccctg cagcggcata a

Last modification date: Oct. 2, 2011