Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: UV excision repair protein RAD23


DESCRIPTION:
Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.

MISCELLANEOUS:
Present with 10900 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Contains 2 UBA domains.
Contains 1 ubiquitin-like domain.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MVSLTFKNFK KEKVPLDLEP SNTILETKTK LAQSISCEES QIKLIYSGKV LQDSKTVSEC
        70         80         90        100        110        120
GLKDGDQVVF MVSQKKSTKT KVTEPPIAPE SATTPGRENS TEASPSTDAS AAPAATAPEG
       130        140        150        160        170        180
SQPQEEQTAT TERTESASTP GFVVGTERNE TIERIMEMGY QREEVERALR AAFNNPDRAV
       190        200        210        220        230        240
EYLLMGIPEN LRQPEPQQQT AAAAEQPSTA ATTAEQPAED DLFAQAAQGG NASSGALGTT
       250        260        270        280        290        300
GGATDAAQGG PPGSIGLTVE DLLSLRQVVS GNPEALAPLL ENISARYPQL REHIMANPEV
       310        320        330        340        350        360
FVSMLLEAVG DNMQDVMEGA DDMVEGEDIE VTGEAAAAGL GQGEGEGSFQ VDYTPEDDQA
       370        380        390
ISRLCELGFE RDLVIQVYFA CDKNEEAAAN ILFSDHAD  

Encoded by RAD23 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggttagct taacctttaa aaatttcaag aaggaaaaag ttcctttaga tctggaacct
        70         80         90        100        110        120
tcaaacacaa ttttagagac caagaccaag cttgctcaat ccatttcttg tgaagaatct
       130        140        150        160        170        180
caaataaaac tgatctactc gggtaaagtg ctacaagatt ccaaaaccgt atcggaatgc
       190        200        210        220        230        240
gggctaaaag atggggacca agttgtcttc atggtttctc aaaaaaagtc cacgaagacc
       250        260        270        280        290        300
aaagtaacag aacctccaat tgctcctgag agcgccacta cccccggaag agaaaattct
       310        320        330        340        350        360
acagaagcat cccccagtac ggatgcttct gcagctcctg cagccactgc tcccgaaggc
       370        380        390        400        410        420
tcacaaccgc aagaagaaca aaccgccact acagaacgta ctgaatctgc ctctacaccg
       430        440        450        460        470        480
ggattcgtgg tgggaaccga gaggaacgag accatcgaga gaatcatgga aatgggctac
       490        500        510        520        530        540
caaagagagg aagtcgaacg agccttgaga gcagccttta ataatccaga tagagcggtg
       550        560        570        580        590        600
gaatatctac tgatgggtat tccagaaaat ctgcgtcaac cggaaccaca gcaacaaaca
       610        620        630        640        650        660
gccgccgcag cggaacaacc atcgacagcc gccaccactg cggaacaacc ggctgaagac
       670        680        690        700        710        720
gacttatttg cacaagctgc ccaaggcggt aatgcttcat ccggtgcgct tggcacaact
       730        740        750        760        770        780
ggaggagcta cagatgctgc gcaaggtgga cctccaggtt ccattggcct cactgtagaa
       790        800        810        820        830        840
gatttactat cgttgagaca ggtcgtttca ggtaacccag aagctttagc cccattgttg
       850        860        870        880        890        900
gaaaacataa gtgctagata tcctcaatta cgtgaacata tcatggcaaa cccagaagtg
       910        920        930        940        950        960
tttgtgtcca tgttgctaga agccgtgggt gacaatatgc aagatgttat ggaaggtgcg
       970        980        990       1000       1010       1020
gatgatatgg tggaaggaga ggatatagaa gttacaggag aggctgctgc tgcaggactg
      1030       1040       1050       1060       1070       1080
ggacaaggtg aaggtgaagg ttctttccaa gttgactata cccccgaaga cgatcaagct
      1090       1100       1110       1120       1130       1140
atttcgcgcc tctgtgaatt gggctttgaa agagatcttg ttatccaggt gtattttgcg
      1150       1160       1170       1180       1190
tgcgataaaa acgaagaagc tgcagcaaat attctattca gcgatcatgc cgactga

Last modification date: Oct. 2, 2011