Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: RING-box protein HRT1


DESCRIPTION:
Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like CDC34/UBC3, to the complex and brings it into close proximity to the substrate. Also stimulates CDC34/UBC3 autoubiquitination and promotes the neddylation of CDC53.

STRUCTURE SIMILARITY:
Contains 1 RING-type zinc finger.
Belongs to the RING-box family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSNEVDRMDV DEDESQNIAQ SSNQSAPVET KKKRFEIKKW TAVAFWSWDI AVDNCAICRN
        70         80         90        100        110        120
HIMEPCIECQ PKAMTDTDNE CVAAWGVCNH AFHLHCINKW IKTRDACPLD NQPWQLARCG

R     

Encoded by HRT1 gene


OTHER NAME(S):
HRT2
RBX1
ROC1


Nucleic acid sequence

        10         20         30         40         50         60
atgagcaacg aagttgacag gatggatgtt gatgaagatg aatcgcaaaa tattgcgcaa
        70         80         90        100        110        120
agctcaaacc aaagtgcgcc agtggaaacc aaaaagaaga gatttgaaat taagaaatgg
       130        140        150        160        170        180
accgcagtgg cgttttggtc atgggatata gctgttgaca actgtgctat ttgcaggaac
       190        200        210        220        230        240
catataatgg aaccatgcat tgaatgccag ccaaaggcca tgacggacac tgataatgaa
       250        260        270        280        290        300
tgtgtagcag cctggggtgt ctgtaatcac gctttccatt tgcactgtat taataaatgg
       310        320        330        340        350        360
atcaagacaa gagacgcatg cccattagat aaccaacctt ggcagttagc aagatgcggt

aggtga     

Last modification date: Oct. 2, 2011