Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: UvrABC system protein C


DESCRIPTION:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

STRUCTURE SIMILARITY:
Contains 1 UVR domain.
Belongs to the uvrC family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
prokaryotic (SOS) response


RELATED DAMAGE:
DNA-psoralen
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
8-oxoG
AP-site
M3dA
M1dG
CPD
B[a]P-guanine
M1A (OPA)
M2G
(6-4)PP
intErstrand crosslinks (ICLs)
intrAstrand crosslink
M1C (OPC)
M3C
OEG
p-BQ-C
p-BQ-A
p-BQ-G
aflatoxin-G


Amino acids sequence

        10         20         30         40         50         60
MSDQFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN LASRKTEALV
        70         80         90        100        110        120
AQIQQIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPFIFLSGD THPRLAMHRG
       130        140        150        160        170        180
AKHAKGEYFG PFPNGYAVRE TLALLQKIFP IRQCENSVYR NRSRPCLQYQ IGRCLGPCVE
       190        200        210        220        230        240
GLVSEEEYAQ QVEYVRLFLS GKDDQVLTQL ISRMETASQN LEFEEAARIR DQIQAVRRVT
       250        260        270        280        290        300
EKQFVSNTGD DLDVIGVAFD AGMACVHVLF IRQGKVLGSR SYFPKVPGGT ELSEVVETFV
       310        320        330        340        350        360
GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRK INVQTKPRGD RARYLKLART
       370        380        390        400        410        420
NAATALTSKL SQQSTVHQRL TALASVLKLP EVKRMECFDI SHTMGEQTVA SCVVFDANGP
       430        440        450        460        470        480
LRAEYRRYNI TGITPGDDYA AMNQVLRRRY GKAIDDSKIP DVILIDGGKG QLAQAKNVFA
       490        500        510        520        530        540
ELDVSWDKNH PLLLGVAKGA DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH
       550        560        570        580        590        600
AIGGHRKKRA KVKNTSSLET IEGVGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL
       610
AEKIFWSLKH     

Encoded by uvrC gene


OTHER NAME(S):
ECK1912
JW1898


DESCRIPTION:
UvrC is one of three (along with UvrA and UvrB) enzyme components participating in the nucleotide excision repair (NER) process. [More information is available at EcoCyc: EG11063].


Nucleic acid sequence

        10         20         30         40         50         60
gtgagtgatc agtttgacgc aaaagcgttt ttaaaaaccg taaccagcca gccaggcgtt
        70         80         90        100        110        120
tatcgcatgt acgatgctgg tggtacggtt atctatgtcg gcaaagcgaa agacctgaaa
       130        140        150        160        170        180
aaacggcttt ccagctattt ccgtagcaac ctcgcttcgc gcaaaaccga agcgctggtc
       190        200        210        220        230        240
gcccagatcc agcaaattga tgtaacggtt actcacacag aaaccgaagc gctgttgctg
       250        260        270        280        290        300
gaacacaact acatcaaact ctatcagccg cgttacaacg ttttgctacg cgatgataaa
       310        320        330        340        350        360
tcatatcctt ttatcttcct gagtggtgat acccacccgc gtctggcgat gcatcgtggt
       370        380        390        400        410        420
gcgaagcatg ccaaaggtga atatttcggc ccgttcccga atggctatgc cgtacgtgaa
       430        440        450        460        470        480
acactggcgc tactgcaaaa gattttcccc attcgccagt gcgaaaatag tgtttatcgc
       490        500        510        520        530        540
aatcgctcgc gtccgtgtct gcaataccag atagggcgct gtctgggacc gtgcgttgaa
       550        560        570        580        590        600
ggactggtga gtgaagaaga atacgctcag caggtcgagt atgtgcgcct gtttttgtct
       610        620        630        640        650        660
ggcaaagatg atcaggtgct tacgcaactc attagtcgta tggaaactgc cagccagaat
       670        680        690        700        710        720
ctggagtttg aagaagctgc acgtattcgc gaccaaattc aggcggtgcg acgcgtcacc
       730        740        750        760        770        780
gaaaaacaat tcgtttccaa taccggcgac gacctcgacg ttattggtgt ggcgttcgat
       790        800        810        820        830        840
gcgggcatgg cttgtgtcca cgtattgttc attcgtcagg gcaaagtgct cggcagccgc
       850        860        870        880        890        900
agctatttcc cgaaagtgcc tggcggtacg gaactgagcg aggtggtaga aaccttcgta
       910        920        930        940        950        960
ggccagttct atttacaagg cagccagatg cgcaccttac cgggtgagat cctgctcgat
       970        980        990       1000       1010       1020
tttaatctta gcgataaaac gctgctcgcc gattcccttt cagaactggc gggacgcaag
      1030       1040       1050       1060       1070       1080
attaatgttc aaaccaaacc tcgcggcgat agggcgcgtt atctgaaact cgcgcgcacc
      1090       1100       1110       1120       1130       1140
aatgcggcga cggccttaac cagcaaactt tcgcagcaat ctaccgttca ccagcgactg
      1150       1160       1170       1180       1190       1200
accgcgcttg ccagcgtgtt gaaattgccg gaagtgaagc ggatggagtg ctttgacatc
      1210       1220       1230       1240       1250       1260
agccatacca tgggcgaaca aaccgtcgct tcctgtgtgg tgtttgatgc taacggcccg
      1270       1280       1290       1300       1310       1320
ctgcgtgcgg agtatcggcg ctataacatt acaggcatca cgccgggcga tgattatgcg
      1330       1340       1350       1360       1370       1380
gcgatgaatc aggtgctgcg tcggcgttat ggtaaagcca ttgacgacag taagatcccg
      1390       1400       1410       1420       1430       1440
gatgtgatcc ttatcgacgg cggcaaaggc cagcttgcgc aggcgaaaaa tgtcttcgcc
      1450       1460       1470       1480       1490       1500
gaactggatg tctcatggga taaaaatcat ccgctgctac ttggcgttgc caaaggagca
      1510       1520       1530       1540       1550       1560
gatcgtaagg ctggactgga aacgctgttc tttgagccgg aaggtgaggg atttagtttg
      1570       1580       1590       1600       1610       1620
ccgccagatt cacccgcgct gcatgttatc cagcatattc gcgatgaatc acatgatcac
      1630       1640       1650       1660       1670       1680
gcgattggcg ggcaccgtaa aaaacgggcg aaggtcaaaa ataccagttc cctggaaacc
      1690       1700       1710       1720       1730       1740
attgaaggcg tcgggccaaa acgtcggcaa atgttgttga aatatatggg cggtttgcaa
      1750       1760       1770       1780       1790       1800
ggtttacgta acgccagcgt cgaggaaatt gcaaaagtgc cgggtatttc gcaaggtctg
      1810       1820       1830
gcagaaaaga tcttctggtc gttgaaacat tga  

Last modification date: Oct. 2, 2011