Homo sapiens L. (human) [HSA]

FULL NAME: General transcription factor IIH subunit 3


DESCRIPTION:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.

STRUCTURE SIMILARITY:
Belongs to the TFB4 family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MVSDEDELNL LVIVVDANPI WWGKQALKES QFTLSKCIDA VMVLGNSHLF MNRSNKLAVI
        70         80         90        100        110        120
ASHIQESRFL YPGKNGRLGD FFGDPGNPPE FNPSGSKDGK YELLTSANEV IVEEIKDLMT
       130        140        150        160        170        180
KSDIKGQHTE TLLAGSLAKA LCYIHRMNKE VKDNQEMKSR ILVIKAAEDS ALQYMNFMNV
       190        200        210        220        230        240
IFAAQKQNIL IDACVLDSDS GLLQQACDIT GGLYLKVPQM PSLLQYLLWV FLPDQDQRSQ
       250        260        270        280        290        300
LILPPPVHVD YRAACFCHRN LIEIGYVCSV CLSIFCNFSP ICTTCETAFK ISLPPVLKAK

KKKLKVSA     

Encoded by GTF2H3 gene

FULL NAME: general transcription factor IIH, polypeptide 3, 34kDa


OTHER NAME(S):
BTF2
TFB4
TFIIH


Nucleic acid sequence

        10         20         30         40         50         60
atggtttcag acgaagatga attgaatctt ctggttattg tagttgatgc caacccaatt
        70         80         90        100        110        120
tggtggggaa agcaagcatt aaaggaatct cagttcactt tatccaaatg catagatgcc
       130        140        150        160        170        180
gtgatggtgc tgggaaattc gcatttattc atgaatcgtt ccaacaaact tgctgtgata
       190        200        210        220        230        240
gcaagtcaca ttcaagaaag ccgattctta tatcctggaa agaatggcag acttggagac
       250        260        270        280        290        300
ttcttcggag accctggcaa ccctcctgaa tttaatccct ctgggagtaa agatggaaaa
       310        320        330        340        350        360
tacgaacttt taacctcagc aaatgaagtt attgttgaag agattaaaga tctaatgacc
       370        380        390        400        410        420
aaaagtgaca taaagggtca acatacagaa actttgctgg caggatccct ggccaaagcc
       430        440        450        460        470        480
ctttgctaca ttcatagaat gaacaaggaa gttaaagaca atcaggaaat gaaatcaagg
       490        500        510        520        530        540
atattggtga ttaaggctgc agaagacagt gcgttgcagt atatgaactt catgaatgtc
       550        560        570        580        590        600
atctttgcag cacagaaaca gaatattttg attgatgcct gtgttttaga ctccgactca
       610        620        630        640        650        660
gggctcctcc aacaggcttg tgacatcacg ggaggactgt acctgaaggt gcctcagatg
       670        680        690        700        710        720
ccttctcttc tgcagtattt gctgtgggtg tttcttcccg atcaagatca gagatctcag
       730        740        750        760        770        780
ttaatcctcc cacccccagt tcatgttgac tacagggctg cttgcttctg tcatcgaaat
       790        800        810        820        830        840
ctcattgaaa ttggttatgt ctgttctgtg tgtttgtcaa tattctgcaa tttcagcccc
       850        860        870        880        890        900
atttgtacta cgtgcgagac agcctttaaa atttctctgc ctccagtgct gaaagccaag
       910        920
aaaaagaaac tgaaagtgtc tgcctga   

Last modification date: Oct. 2, 2011