Homo sapiens L. (human) [HSA]

FULL NAME: General transcription factor IIH subunit 1


DESCRIPTION:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

STRUCTURE SIMILARITY:
Contains 2 BSD domains.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MATSSEEVLL IVKKVRQKKQ DGALYLMAER IAWAPEGKDR FTISHMYADI KCQKISPEGK
        70         80         90        100        110        120
AKIQLQLVLH AGDTTNFHFS NESTAVKERD AVKDLLQQLL PKFKRKANKE LEEKNRMLQE
       130        140        150        160        170        180
DPVLFQLYKD LVVSQVISAE EFWANRLNVN ATDSSSTSNH KQDVGISAAF LADVRPQTDG
       190        200        210        220        230        240
CNGLRYNLTS DIIESIFRTY PAVKMKYAEN VPHNMTEKEF WTRFFQSHYF HRDRLNTGSK
       250        260        270        280        290        300
DLFAECAKID EKGLKTMVSL GVKNPLLDLT ALEDKPLDEG YGISSVPSAS NSKSIKENSN
       310        320        330        340        350        360
AAIIKRFNHH SAMVLAAGLR KQEAQNEQTS EPSNMDGNSG DADCFQPAVK RAKLQESIEY
       370        380        390        400        410        420
EDLGKNNSVK TIALNLKKSD RYYHGPTPIQ SLQYATSQDI INSFQSIRQE MEAYTPKLTQ
       430        440        450        460        470        480
VLSSSAASST ITALSPGGAL MQGGTQQAIN QMVPNDIQSE LKHLYVAVGE LLRHFWSCFP
       490        500        510        520        530        540
VNTPFLEEKV VKMKSNLERF QVTKLCPFQE KIRRQYLSTN LVSHIEEMLQ TAYNKLHTWQ

SRRLMKKT     

Encoded by GTF2H1 gene

FULL NAME: general transcription factor IIH, polypeptide 1, 62kDa


OTHER NAME(S):
BTF2
TFB1
TFIIH


Nucleic acid sequence

        10         20         30         40         50         60
atggcaacct catctgaaga agttttgctg attgtaaaga aagtgcgtca aaagaagcag
        70         80         90        100        110        120
gatggagctc tgtacctcat ggcagaaaga attgcttggg cacctgaagg caaagataga
       130        140        150        160        170        180
tttacaatca gccatatgta tgcagatatt aaatgccaga aaattagtcc agaaggaaaa
       190        200        210        220        230        240
gctaaaattc agcttcagct ggtcctacat gcaggggaca caactaactt ccatttttcc
       250        260        270        280        290        300
aatgaaagca cagcagtgaa agagcgagat gcagtaaaag accttcttca gcagctgctg
       310        320        330        340        350        360
cccaaattca agaggaaagc aaataaagaa ctggaagaga agaacagaat gctgcaagaa
       370        380        390        400        410        420
gatcctgttt tgtttcagct ttataaagac cttgttgtga gtcaagtgat cagtgctgag
       430        440        450        460        470        480
gaattctggg ccaatcgttt aaatgtgaat gcaacagata gttcttccac atccaatcat
       490        500        510        520        530        540
aagcaggatg ttggcatttc tgctgcattt ctggctgatg tccggcccca aactgatggc
       550        560        570        580        590        600
tgtaacggtc taagatataa tttaacttct gatatcattg agtccatatt taggacctat
       610        620        630        640        650        660
ccagcagtaa aaatgaaata tgcagaaaat gttccccaca acatgacaga gaaggaattc
       670        680        690        700        710        720
tggacacgtt ttttccagtc ccattatttt cacagggatc ggctgaatac agggtcaaag
       730        740        750        760        770        780
gatctctttg cagaatgtgc caaaatagat gaaaaaggcc taaaaacaat ggtttcatta
       790        800        810        820        830        840
ggagtgaaaa acccactact agatttaaca gctttggaag ataaaccatt agatgagggc
       850        860        870        880        890        900
tatggcattt cctctgtgcc atctgcttcc aattctaaat ccataaaaga gaatagtaat
       910        920        930        940        950        960
gctgccatca tcaagagatt taaccatcac agtgccatgg tcctggcagc tggactcaga
       970        980        990       1000       1010       1020
aaacaagaag cacaaaatga acaaactagt gagcccagca acatggatgg aaattccgga
      1030       1040       1050       1060       1070       1080
gatgcagact gctttcagcc agcagtcaaa agggcgaaat tacaagagtc cattgaatat
      1090       1100       1110       1120       1130       1140
gaagacttgg ggaaaaataa ttctgtaaaa acgattgcac taaacctcaa gaagtcagat
      1150       1160       1170       1180       1190       1200
aggtattatc atggtccaac tccaatccag tcactacagt atgcaacaag tcaggacatt
      1210       1220       1230       1240       1250       1260
attaattctt ttcaaagtat tagacaagaa atggaagctt atacacccaa gttaactcag
      1270       1280       1290       1300       1310       1320
gttctctcaa gtagtgctgc cagtagtacc atcacagcac tgtcacctgg aggggcactt
      1330       1340       1350       1360       1370       1380
atgcagggag gaacacagca agccataaac cagatggtgc caaatgatat tcaatctgaa
      1390       1400       1410       1420       1430       1440
ttgaaacact tatatgtagc tgttggagaa cttctacgac atttctggtc ctgctttcct
      1450       1460       1470       1480       1490       1500
gttaatacgc cattcctaga agaaaaggta gtgaaaatga aaagtaattt ggaacgattc
      1510       1520       1530       1540       1550       1560
caagttacga agctctgtcc attccaagaa aagattcgga gacagtattt aagcacaaat
      1570       1580       1590       1600       1610       1620
ttggtaagtc acatagaaga gatgctccag acagcctaca acaagctcca cacatggcag
      1630       1640
tcacggcgtc tgatgaagaa aacgtga   

Last modification date: Oct. 2, 2011