Homo sapiens L. (human) [HSA]

FULL NAME: TFIIH basal transcription factor complex helicase XPB subunit


DESCRIPTION:
ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.

STRUCTURE SIMILARITY:
Contains 1 helicase C-terminal domain.
Contains 1 helicase ATP-binding domain.
Belongs to the helicase family. RAD25/XPB subfamily.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


PROTEIN TYPE(S):
3'-5' DNA helicase


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


RELATED DISEASE(S):
xeroderma pigmentosum, complementation group B (XPB)
TrichoThioDystrophy Photosensitive (TTDP)


Amino acids sequence

        10         20         30         40         50         60
MGKRDRADRD KKKSRKRHYE DEEDDEEDAP GNDPQEAVPS AAGKQVDESG TKVDEYGAKD
        70         80         90        100        110        120
YRLQMPLKDD HTSRPLWVAP DGHIFLEAFS PVYKYAQDFL VAIAEPVCRP THVHEYKLTA
       130        140        150        160        170        180
YSLYAAVSVG LQTSDITEYL RKLSKTGVPD GIMQFIKLCT VSYGKVKLVL KHNRYFVESC
       190        200        210        220        230        240
HPDVIQHLLQ DPVIRECRLR NSEGEATELI TETFTSKSAI SKTAESSGGP STSRVTDPQG
       250        260        270        280        290        300
KSDIPMDLFD FYEQMDKDEE EEEETQTVSF EVKQEMIEEL QKRCIHLEYP LLAEYDFRND
       310        320        330        340        350        360
SVNPDINIDL KPTAVLRPYQ EKSLRKMFGN GRARSGVIVL PCGAGKSLVG VTAACTVRKR
       370        380        390        400        410        420
CLVLGNSAVS VEQWKAQFKM WSTIDDSQIC RFTSDAKDKP IGCSVAISTY SMLGHTTKRS
       430        440        450        460        470        480
WEAERVMEWL KTQEWGLMIL DEVHTIPAKM FRRVLTIVQA HCKLGLTATL VREDDKIVDL
       490        500        510        520        530        540
NFLIGPKLYE ANWMELQNNG YIAKVQCAEV WCPMSPEFYR EYVAIKTKKR ILLYTMNPNK
       550        560        570        580        590        600
FRACQFLIKF HERRNDKIIV FADNVFALKE YAIRLNKPYI YGPTSQGERM QILQNFKHNP
       610        620        630        640        650        660
KINTIFISKV GDTSFDLPEA NVLIQISSHG GSRRQEAQRL GRVLRAKKGM VAEEYNAFFY
       670        680        690        700        710        720
SLVSQDTQEM AYSTKRQRFL VDQGYSFKVI TKLAGMEEED LAFSTKEEQQ QLLQKVLAAT
       730        740        750        760        770        780
DLDAEEEVVA GEFGSRSSQA SRRFGTMSSM SGADDTVYME YHSSRSKAPS KHVHPLFKRF

RK     

Encoded by ERCC3 gene

FULL NAME: excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)


OTHER NAME(S):
BTF2
GTF2H
RAD25
TFIIH
XPB


DESCRIPTION:
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgggcaaaa gagaccgagc ggaccgcgac aagaagaaat ccaggaagcg gcactatgag
        70         80         90        100        110        120
gatgaagagg atgatgaaga ggacgccccg gggaacgacc ctcaggaagc ggttccctcg
       130        140        150        160        170        180
gcggcgggga agcaggtgga tgagtcaggc accaaagtgg atgaatatgg agccaaggac
       190        200        210        220        230        240
tacaggctgc aaatgccgct gaaggacgac cacacctcca ggcccctctg ggtggctccc
       250        260        270        280        290        300
gatggccata tcttcttgga agccttctct ccagtttaca aatatgccca agacttcttg
       310        320        330        340        350        360
gtggctattg cagagccagt gtgccgacca acccatgtgc atgagtacaa actaactgcc
       370        380        390        400        410        420
tactccttgt atgcagctgt cagcgttggg ctgcaaacca gtgacatcac cgagtacctc
       430        440        450        460        470        480
aggaagctca gcaagactgg agtccctgat ggaattatgc agtttattaa gttgtgtact
       490        500        510        520        530        540
gtcagctatg gaaaagtcaa gctggtcttg aagcacaaca gatacttcgt tgaaagttgc
       550        560        570        580        590        600
caccctgatg taatccagca tcttctccag gaccccgtga tccgagaatg ccgcttaaga
       610        620        630        640        650        660
aactctgaag gggaggccac tgagctcatc acagagactt tcacaagcaa atctgccatt
       670        680        690        700        710        720
tctaagactg ctgaaagcag tggtgggccc tccacttccc gagtgacaga tccacagggt
       730        740        750        760        770        780
aaatctgaca tccccatgga cctgtttgac ttctatgagc aaatggacaa ggatgaagaa
       790        800        810        820        830        840
gaagaagaag agacacagac agtgtctttt gaagtcaagc aggaaatgat tgaggaactc
       850        860        870        880        890        900
cagaaacgtt gcatccacct ggagtaccct ctgttggcag aatatgactt ccggaatgat
       910        920        930        940        950        960
tctgtcaacc ctgatatcaa cattgaccta aagcccacag ctgtcctcag accctatcag
       970        980        990       1000       1010       1020
gagaagagct tgcgaaagat gtttggaaac gggcgtgcac gttcgggggt cattgttctt
      1030       1040       1050       1060       1070       1080
ccctgcggtg ctggaaagtc cctggttggt gtgactgctg catgcactgt cagaaaacgc
      1090       1100       1110       1120       1130       1140
tgtctggtgc tgggcaactc agctgtttct gtggagcagt ggaaagccca gttcaagatg
      1150       1160       1170       1180       1190       1200
tggtccacca ttgacgacag ccagatctgc cggttcacct ccgatgccaa ggacaagccc
      1210       1220       1230       1240       1250       1260
atcggctgct ccgttgccat tagcacctac tccatgctgg gccacaccac caaaaggtcc
      1270       1280       1290       1300       1310       1320
tgggaggccg agcgagtcat ggagtggctc aagacccagg agtggggcct catgatcctg
      1330       1340       1350       1360       1370       1380
gatgaagtgc acaccatacc agccaagatg ttccgaaggg tgctcaccat cgtgcaggcc
      1390       1400       1410       1420       1430       1440
cactgtaagc tgggtttgac tgcgaccctc gtccgcgaag atgacaaaat tgtggattta
      1450       1460       1470       1480       1490       1500
aattttctga ttgggcctaa gctctacgaa gccaactgga tggagctgca gaataatggc
      1510       1520       1530       1540       1550       1560
tacatcgcca aagtccagtg tgctgaggtc tggtgcccta tgtctcctga attttaccgg
      1570       1580       1590       1600       1610       1620
gaatatgtgg caatcaaaac caagaaacga atcttgctgt acaccatgaa ccccaacaaa
      1630       1640       1650       1660       1670       1680
tttagagctt gccagtttct gatcaagttt catgaaagga ggaatgacaa gattattgtc
      1690       1700       1710       1720       1730       1740
tttgctgaca atgtgtttgc cctaaaggaa tatgccattc gactgaacaa accctatatc
      1750       1760       1770       1780       1790       1800
tacggaccta cgtctcaggg ggaaaggatg caaattctcc agaatttcaa gcacaacccc
      1810       1820       1830       1840       1850       1860
aaaattaaca ccatcttcat atccaaggta ggtgacactt cgtttgatct gccggaagca
      1870       1880       1890       1900       1910       1920
aatgtcctca ttcagatctc atcccatggt ggctccaggc gtcaggaagc ccaaaggcta
      1930       1940       1950       1960       1970       1980
gggcgggtgc ttcgagctaa aaaagggatg gttgcagaag agtacaatgc ctttttctac
      1990       2000       2010       2020       2030       2040
tcactggtat cccaggacac acaggaaatg gcttactcaa ccaagcggca gagattcttg
      2050       2060       2070       2080       2090       2100
gtagatcaag gttatagctt caaggtgatc acgaaactcg ctggcatgga ggaggaagac
      2110       2120       2130       2140       2150       2160
ttggcgtttt cgacaaaaga agagcaacag cagctcttac agaaagtcct ggcagccact
      2170       2180       2190       2200       2210       2220
gacctggatg ccgaggagga ggtggtggct ggggaatttg gctccagatc cagccaggca
      2230       2240       2250       2260       2270       2280
tctcggcgct ttggcaccat gagttctatg tctggggccg acgacactgt gtacatggag
      2290       2300       2310       2320       2330       2340
taccactcat cgcggagcaa ggcgcccagc aaacatgtac acccgctctt caagcgcttt

aggaaatga     

Last modification date: Oct. 2, 2011