Homo sapiens L. (human) [HSA]

FULL NAME: Ribonuclease H2 subunit B


DESCRIPTION:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

STRUCTURE SIMILARITY:
Belongs to the RNase H2 subunit B family.


SUBUNIT STRUCTURE:
The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.


RELATED PATHWAY(S):
DNA replication


RELATED DISEASE(S):
Aicardi-Goutieres syndrome type 2 (AGS2)


Amino acids sequence

        10         20         30         40         50         60
MAAGVDCGDG VGARQHVFLV SEYLKDASKK MKNGLMFVKL VNPCSGEGAI YLFNMCLQQL
        70         80         90        100        110        120
FEVKVFKEKH HSWFINQSVQ SGGLLHFATP VDPLFLLLHY LIKADKEGKF QPLDQVVVDN
       130        140        150        160        170        180
VFPNCILLLK LPGLEKLLHH VTEEKGNPEI DNKKYYKYSK EKTLKWLEKK VNQTVAALKT
       190        200        210        220        230        240
NNVNVSSRVQ STAFFSGDQA STDKEEDYIR YAHGLISDYI PKELSDDLSK YLKLPEPSAS
       250
LPNPPSKMAA QRQKRGK    

Encoded by RNASEH2B gene

FULL NAME: ribonuclease H2, subunit B


OTHER NAME(S):
AGS2
DLEU8
FLJ11712


DESCRIPTION:
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggccgctg gcgtggactg cggggacggg gttggcgccc ggcagcacgt gttcctggtt
        70         80         90        100        110        120
tcagaatatt taaaagatgc ttcaaagaag atgaaaaatg ggctaatgtt tgtaaaactg
       130        140        150        160        170        180
gttaacccct gttcaggaga aggagccatt tacttgttca atatgtgtct acagcagctg
       190        200        210        220        230        240
tttgaagtaa aagttttcaa ggaaaaacac cattcttggt ttataaatca atcagttcaa
       250        260        270        280        290        300
tcaggaggtc ttctccattt tgccacacct gtggatcctc tatttctgct tctccactac
       310        320        330        340        350        360
ctcataaagg ctgataagga ggggaagttt cagccccttg atcaagttgt ggtggataac
       370        380        390        400        410        420
gtgtttccaa attgcatctt gttgctgaaa cttcctggac ttgagaagtt acttcatcat
       430        440        450        460        470        480
gtgacagagg aaaaaggtaa tccagaaata gacaacaaga aatattacaa gtacagcaaa
       490        500        510        520        530        540
gagaagacat taaagtggct ggaaaaaaag gttaatcaaa ctgtggcagc attaaaaacc
       550        560        570        580        590        600
aataatgtga atgtcagttc ccgggtacag tcaactgcat ttttctctgg tgaccaagct
       610        620        630        640        650        660
tccactgaca aggaagagga ttatattcgt tatgcccatg gtctgatatc tgactacatc
       670        680        690        700        710        720
cctaaagaat taagtgatga cttatctaaa tacttaaagc ttccagaacc ttcagcctca
       730        740        750        760        770
ttgccaaatc ctccatcaaa gatggcagca caaagacaga aaaggggcaa gtga

Last modification date: Oct. 19, 2011