Homo sapiens L. (human) [HSA]

FULL NAME: Cyclin-H


DESCRIPTION:
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

STRUCTURE SIMILARITY:
Belongs to the cyclin family. Cyclin C subfamily.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY
        70         80         90        100        110        120
EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV
       130        140        150        160        170        180
SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI
       190        200        210        220        230        240
LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE
       250        260        270        280        290        300
NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD
       310        320
DYVSKKSKHE EEEWTDDDLV ESL   

Encoded by CCNH gene

FULL NAME: cyclin H


OTHER NAME(S):
CAK
p34
p37


DESCRIPTION:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atgtaccaca acagtagtca gaagcggcac tggaccttct ccagcgagga gcagctggca
        70         80         90        100        110        120
agactgcggg ctgacgccaa ccgcaaattc agatgcaaag ccgtggccaa cgggaaggtt
       130        140        150        160        170        180
cttccgaatg atccagtctt tcttgagcct catgaagaaa tgacactctg caaatactat
       190        200        210        220        230        240
gagaaaaggt tattggaatt ctgttcggtg tttaagccag caatgccaag atctgttgtg
       250        260        270        280        290        300
ggtacggctt gtatgtattt caaacgtttt tatcttaata actcagtaat ggaatatcac
       310        320        330        340        350        360
cccaggataa taatgctcac ttgtgcattt ttggcctgca aagtagatga attcaatgta
       370        380        390        400        410        420
tctagtcctc agtttgttgg aaacctccgg gagagtcctc ttggacagga gaaggcactt
       430        440        450        460        470        480
gaacagatac tggaatatga actacttctt atacagcaac ttaatttcca ccttattgtc
       490        500        510        520        530        540
cacaatcctt acagaccatt tgagggcttc ctcatcgact taaagacccg ctatcccata
       550        560        570        580        590        600
ttggagaatc cagagatttt gaggaaaaca gctgatgact ttcttaatag aattgcattg
       610        620        630        640        650        660
acggatgctt accttttata cacaccttcc caaattgccc tgactgccat tttatctagt
       670        680        690        700        710        720
gcctccaggg ctggaattac tatggaaagt tatttatcag agagtctgat gctgaaagag
       730        740        750        760        770        780
aacagaactt gcctgtcaca gttactagat ataatgaaaa gcatgagaaa cttagtaaag
       790        800        810        820        830        840
aagtatgaac cacccagatc tgaagaagtt gctgttctga aacagaagtt ggagcgatgt
       850        860        870        880        890        900
cattctgctg agcttgcact taacgtaatc acgaagaaga ggaaaggcta tgaagatgat
       910        920        930        940        950        960
gattacgtct caaagaaatc caaacatgag gaggaagaat ggactgatga cgacctggta
       970
gaatctctct aa    

Last modification date: Oct. 2, 2011