Homo sapiens L. (human) [HSA]

FULL NAME: Cyclin-dependent kinase 7


DESCRIPTION:
Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.


ENZYME REGULATION:
Inactivated by phosphorylation.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylation of Thr-170 is required for activity.
Phosphorylation of Ser-164 during mitosis inactivates the enzyme.


PROTEIN TYPE(S):
kinase


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL
        70         80         90        100        110        120
REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM
       130        140        150        160        170        180
TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA
       190        200        210        220        230        240
PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM
       250        260        270        280        290        300
CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG
       310        320        330        340
PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF 

Encoded by CDK7 gene

FULL NAME: cyclin-dependent kinase 7


OTHER NAME(S):
CAK1
CDKN7
MO15
STK1
p39MO15
HCAK


DESCRIPTION:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggctctgg acgtgaagtc tcgggcaaag cgttatgaga agctggactt ccttggggag
        70         80         90        100        110        120
ggacagtttg ccaccgttta caaggccaga gataagaaca ccaaccaaat tgtcgccatt
       130        140        150        160        170        180
aagaaaatca aacttggaca tagatcagaa gctaaagatg gtataaatag aaccgcctta
       190        200        210        220        230        240
agagagataa aattattaca ggagctaagt catccaaata taattggtct ccttgatgct
       250        260        270        280        290        300
tttggacata aatctaatat tagccttgtc tttgatttta tggaaactga tctagaggtt
       310        320        330        340        350        360
ataataaagg ataatagtct tgtgctgaca ccatcacaca tcaaagccta catgttgatg
       370        380        390        400        410        420
actcttcaag gattagaata tttacatcaa cattggatcc tacataggga tctgaaacca
       430        440        450        460        470        480
aacaacttgt tgctagatga aaatggagtt ctaaaactgg cagattttgg cctggccaaa
       490        500        510        520        530        540
tcttttggga gccccaatag agcttataca catcaggttg taaccaggtg gtatcgggcc
       550        560        570        580        590        600
cccgagttac tatttggagc taggatgtat ggtgtaggtg tggacatgtg ggctgttggc
       610        620        630        640        650        660
tgtatattag cagagttact tctaagggtt ccttttttgc caggagattc agaccttgat
       670        680        690        700        710        720
cagctaacaa gaatatttga aactttgggc acaccaactg aggaacagtg gccggacatg
       730        740        750        760        770        780
tgtagtcttc cagattatgt gacatttaag agtttccctg gaataccttt gcatcacatc
       790        800        810        820        830        840
ttcagtgcag caggagacga cttactagat ctcatacaag gcttattctt atttaatcca
       850        860        870        880        890        900
tgtgctcgaa ttacggccac acaggcactg aaaatgaagt atttcagtaa tcggccaggg
       910        920        930        940        950        960
ccaacacctg gatgtcagct gccaagacca aactgtccag tggaaacctt aaaggagcaa
       970        980        990       1000       1010       1020
tcaaatccag ctttggcaat aaaaaggaaa agaacagagg ccttagaaca aggaggattg
      1030       1040
cccaagaaac taatttttta a   

Last modification date: Oct. 2, 2011