Homo sapiens L. (human) [HSA]

FULL NAME: Centrin-2


DESCRIPTION:
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110.

MISCELLANEOUS:
Binds two moles of calcium per mole of protein.


STRUCTURE SIMILARITY:
Contains 4 EF-hand domains.
Belongs to the centrin family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL
        70         80         90        100        110        120
GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK
       130        140        150        160        170
ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY

Encoded by CETN2 gene

FULL NAME: centrin, EF-hand protein, 2


OTHER NAME(S):
CALT
CEN2


DESCRIPTION:
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcctcca actttaagaa ggcaaacatg gcatcaagtt ctcagcgaaa aagaatgagc
        70         80         90        100        110        120
cctaagcctg agcttactga agagcaaaag caggagatcc gggaagcttt tgatcttttc
       130        140        150        160        170        180
gatgcggatg gaactggcac catagatgtt aaagaactga aggtggcaat gagggccctg
       190        200        210        220        230        240
ggctttgaac ccaagaaaga agaaattaag aaaatgataa gtgaaattga taaggaaggg
       250        260        270        280        290        300
acaggaaaaa tgaactttgg tgacttttta actgtgatga cccagaaaat gtctgagaaa
       310        320        330        340        350        360
gatactaaag aagaaatcct gaaagctttc aagctctttg atgatgatga aactgggaag
       370        380        390        400        410        420
atttcgttca aaaatctgaa acgcgtggcc aaggagttgg gtgagaacct gactgatgag
       430        440        450        460        470        480
gagctgcagg aaatgattga tgaagctgat cgagatggag atggagaggt cagtgagcaa
       490        500        510
gagttcctgc gcatcatgaa aaagaccagc ctctattaa  

Last modification date: Oct. 2, 2011