Homo sapiens L. (human) [HSA]

FULL NAME: UV excision repair protein RAD23 homolog A


DESCRIPTION:
Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

STRUCTURE SIMILARITY:
Belongs to the RAD23 family.
Contains 2 UBA domains.
Contains 1 ubiquitin-like domain.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP
        70         80         90        100        110        120
IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE
       130        140        150        160        170        180
DKSPSEESAP TTSPESVSGS VPSSGSSGRE EDAASTLVTG SEYETMLTEI MSMGYERERV
       190        200        210        220        230        240
VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ
       250        260        270        280        290        300
FQNMRQVIQQ NPALLPALLQ QLGQENPQLL QQISRHQEQF IQMLNEPPGE LADISDVEGE
       310        320        330        340        350        360
VGAIGEEAPQ MNYIQVTPQE KEAIERLKAL GFPESLVIQA YFACEKNENL AANFLLSQNF

DDE     

Encoded by RAD23A gene

FULL NAME: RAD23 homolog A (S. cerevisiae)


OTHER NAME(S):
HHR23A
MGC111083


DESCRIPTION:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggccgtca ccatcacgct caaaacgctg cagcagcaga ccttcaagat ccgcatggag
        70         80         90        100        110        120
cctgacgaga cggtgaaggt gctaaaggag aagatagaag ctgagaaggg tcgtgatgcc
       130        140        150        160        170        180
ttccccgtgg ctggacagaa actcatctat gccggcaaga tcttgagtga cgatgtccct
       190        200        210        220        230        240
atcagggact atcgcatcga tgagaagaac tttgtggtcg tcatggtgac caagaccaaa
       250        260        270        280        290        300
gccggccagg gtacctcagc acccccagag gcctcaccca cagctgcccc agagtcctct
       310        320        330        340        350        360
acatccttcc cgcctgcccc cacctcaggc atgtcccatc ccccacctgc cgccagagag
       370        380        390        400        410        420
gacaagagcc catcagagga atccgccccc acgacgtccc cagagtctgt gtcaggctct
       430        440        450        460        470        480
gttccctctt caggtagcag cgggcgagag gaagacgcgg cctccacgct agtgacgggc
       490        500        510        520        530        540
tctgagtatg agacgatgct gacggagatc atgtccatgg gctatgagcg agagcgggtc
       550        560        570        580        590        600
gtggccgccc tgagagccag ctacaacaac ccccaccgag ccgtggagta tctgctcacg
       610        620        630        640        650        660
ggaattcctg ggagccccga gccggaacac ggttctgtcc aggagagcca ggtatcggag
       670        680        690        700        710        720
cagccggcca cggaagcagc aggagagaac cccctggagt tcctgcggga ccagccccag
       730        740        750        760        770        780
ttccagaaca tgcggcaggt gattcagcag aaccctgcgc tgctgcccgc cctgctccag
       790        800        810        820        830        840
cagctgggcc aggagaaccc tcagctttta cagcaaatca gccggcacca ggagcagttc
       850        860        870        880        890        900
atccagatgc tgaacgagcc ccctggggag ctggcggaca tctcagatgt ggagggggag
       910        920        930        940        950        960
gtgggcgcca taggagagga ggccccgcag atgaactaca tccaggtgac gccgcaggag
       970        980        990       1000       1010       1020
aaagaagcta tagagaggtt gaaggccctg ggcttcccag agagcctggt catccaggcc
      1030       1040       1050       1060       1070       1080
tatttcgcgt gtgaaaaaaa tgagaacttg gctgccaact tcctcctgag tcagaacttt
      1090
gatgacgagt ga    

Last modification date: Oct. 2, 2011