Homo sapiens L. (human) [HSA]

FULL NAME: Ribonuclease H2 subunit A


DESCRIPTION:
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

STRUCTURE SIMILARITY:
Belongs to the RNase HII family. Eukaryotic subfamily.


SUBUNIT STRUCTURE:
The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.


CATALYTIC ACTIVITY:
Endonucleolytic cleavage to 5'-phosphomonoester.


PROTEIN TYPE(S):
RNase


RELATED PATHWAY(S):
DNA replication


RELATED DISEASE(S):
Aicardi-Goutieres syndrome 4 (AGS4)


Amino acids sequence

        10         20         30         40         50         60
MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL
        70         80         90        100        110        120
EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT
       130        140        150        160        170        180
ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI
       190        200        210        220        230        240
CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT
       250        260        270        280        290
AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL

Encoded by RNASEH2A gene

FULL NAME: ribonuclease H2, subunit A


OTHER NAME(S):
AGS4
JUNB
RNASEHI
RNHIA
RNHL


DESCRIPTION:
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]


Nucleic acid sequence

        10         20         30         40         50         60
atggatctca gcgagctgga gagagacaat acaggccgct gtcgcctgag ttcgcctgtg
        70         80         90        100        110        120
cccgcggtgt gccgcaagga gccttgcgtc ctgggcgtcg atgaggcggg caggggcccc
       130        140        150        160        170        180
gtgctgggcc ccatggtcta cgccatctgt tattgtcccc tgcctcgcct ggcagatctg
       190        200        210        220        230        240
gaggcgctga aagtggcaga ctcaaagacc ctattggaga gcgagcggga aaggctgttt
       250        260        270        280        290        300
gcgaaaatgg aggacacgga ctttgtcggc tgggcgctgg atgtgctgtc tccaaacctc
       310        320        330        340        350        360
atctctacca gcatgcttgg gcgggtcaaa tacaacctga actccctgtc acatgataca
       370        380        390        400        410        420
gccactgggc ttatacagta tgcattggac cagggcgtga acgtcaccca ggtattcgtg
       430        440        450        460        470        480
gacaccgtag ggatgccaga gacataccag gcgcggctgc agcaaagttt tcccgggatt
       490        500        510        520        530        540
gaggtgacgg tcaaggccaa agcagatgcc ctctacccgg tggttagtgc tgccagcatc
       550        560        570        580        590        600
tgtgccaagg tggcccggga ccaggccgtg aagaaatggc agttcgtgga gaaactgcag
       610        620        630        640        650        660
gacttggata ctgattatgg ctcaggctac cccaatgatc ccaagacaaa agcgtggttg
       670        680        690        700        710        720
aaggagcacg tggagcctgt gttcggcttc ccccagtttg tccggttcag ctggcgcacg
       730        740        750        760        770        780
gcccagacca tcctggagaa agaggcggaa gatgttatat gggaggactc agcatccgag
       790        800        810        820        830        840
aatcaggagg gactcaggaa gatcacatcc tacttcctca atgaagggtc ccaagcccgt
       850        860        870        880        890        900
ccccgttctt cccaccgata tttcctggaa cgcggcctgg agtcagcaac cagcctctag

Last modification date: Oct. 8, 2011