Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: Mutator mutT protein


DESCRIPTION:
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.

STRUCTURE SIMILARITY:
Contains 1 nudix hydrolase domain.
Belongs to the Nudix hydrolase family.


CATALYTIC ACTIVITY:
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.


RELATED PATHWAY(S):
modulation of nucleotide pools


RELATED DAMAGE:
8-oxodGTP
8-oxodGDP


Amino acids sequence

        10         20         30         40         50         60
MKKLQIAVGI IRNENNEIFI TRRAADAHMA NKLEFPGGKI EMGETPEQAV VRELQEEVGI
        70         80         90        100        110        120
TPQHFSLFEK LEYEFPDRHI TLWFWLVERW EGEPWGKEGQ PGEWMSLVGL NADDFPPANE

PVIAKLKRL     

Encoded by mutT gene


OTHER NAME(S):
ECK0100
JW0097
nudA


DESCRIPTION:
Nudix hydrolase. [More information is available at EcoGene: EG10626]. dGTP pyrophosphohydrolase (MutT) can catalyze the hydrolysis of all eight canonical nucleotides, but it shows a marked preference for dGTP. [More information is available at EcoCyc: EG10626].


Nucleic acid sequence

        10         20         30         40         50         60
atgaaaaagc tgcaaattgc ggtaggtatt attcgcaacg agaacaatga aatctttata
        70         80         90        100        110        120
acgcgtcgcg cagcagatgc gcacatggcg aataaactgg agtttcccgg cggtaaaatt
       130        140        150        160        170        180
gaaatgggtg aaacgccgga acaggcggtg gtgcgtgaac ttcaggaaga agtcgggatt
       190        200        210        220        230        240
accccccaac atttttcgct atttgaaaaa ctggaatatg aattcccgga caggcatata
       250        260        270        280        290        300
acactgtggt tttggctggt cgaacgctgg gaaggggagc cgtggggtaa agaagggcaa
       310        320        330        340        350        360
cccggtgagt ggatgtcgct ggtcggtctt aatgccgatg attttccgcc agccaatgaa
       370        380        390
ccggtaattg cgaagcttaa acgtctgtag   

Last modification date: Oct. 2, 2011