Homo sapiens L. (human) [HSA]

FULL NAME: Cullin-4A


DESCRIPTION:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.

STRUCTURE SIMILARITY:
Belongs to the cullin family.


POST-TRANSLATIONAL MODIFICATION:
Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ
        70         80         90        100        110        120
DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP
       130        140        150        160        170        180
FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY VLQNSTLPSI WDMGLELFRT
       190        200        210        220        230        240
HIISDKMVQS KTIDGILLLI ERERSGEAVD RSLLRSLLGM LSDLQVYKDS FELKFLEETN
       250        260        270        280        290        300
CLYAAEGQRL MQEREVPEYL NHVSKRLEEE GDRVITYLDH STQKPLIACV EKQLLGEHLT
       310        320        330        340        350        360
AILQKGLDHL LDENRVPDLA QMYQLFSRVR GGQQALLQHW SEYIKTFGTA IVINPEKDKD
       370        380        390        400        410        420
MVQDLLDFKD KVDHVIEVCF QKNERFVNLM KESFETFINK RPNKPAELIA KHVDSKLRAG
       430        440        450        460        470        480
NKEATDEELE RTLDKIMILF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK
       490        500        510        520        530        540
HECGAAFTSK LEGMFKDMEL SKDIMVHFKQ HMQNQSDSGP IDLTVNILTM GYWPTYTPME
       550        560        570        580        590        600
VHLTPEMIKL QEVFKAFYLG KHSGRKLQWQ TTLGHAVLKA EFKEGKKEFQ VSLFQTLVLL
       610        620        630        640        650        660
MFNEGDGFSF EEIKMATGIE DSELRRTLQS LACGKARVLI KSPKGKEVED GDKFIFNGEF
       670        680        690        700        710        720
KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAI VRIMKMRKTL GHNLLVSELY
       730        740        750
NQLKFPVKPG DLKKRIESLI DRDYMERDKD NPNQYHYVA  

Encoded by CUL4A gene

FULL NAME: cullin 4A


DESCRIPTION:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggacg aggccccgcg gaagggcagc ttctcggcgc tcgtgggccg caccaacggc
        70         80         90        100        110        120
ctcaccaagc ccgcggccct ggccgccgcg cccgccaagc cggggggcgc gggcggctcc
       130        140        150        160        170        180
aagaagctgg tcatcaagaa cttccgagac agacctcggc tgcccgacaa ctacacgcag
       190        200        210        220        230        240
gacacgtggc ggaagctgca cgaggcggtg cgggccgtgc agagcagcac ctccatcagg
       250        260        270        280        290        300
tacaacctcg aggagctcta ccaggctgtg gaaaatctct gttctcacaa agtctcccca
       310        320        330        340        350        360
atgctctaca agcaactgcg tcaggcctgt gaagaccacg tccaggcaca gatccttccg
       370        380        390        400        410        420
tttagagaag actcactaga tagtgtttta tttttaaaga agattaacac gtgctggcag
       430        440        450        460        470        480
gaccactgca gacaaatgat catgatcaga agcatcttcc tgttcttgga ccgcacctat
       490        500        510        520        530        540
gtgctgcaga actccacgct gccctccatc tgggatatgg gattagaact gtttagaacc
       550        560        570        580        590        600
catattatta gtgataaaat ggttcagagt aaaaccattg atggaatcct actgctgatc
       610        620        630        640        650        660
gagcgcgaga ggagcggcga ggccgtggac cggagcctgt tgcggagcct cctgggcatg
       670        680        690        700        710        720
ctgtctgacc tgcaggtgta taaagattca tttgaactga aatttttgga agagactaat
       730        740        750        760        770        780
tgcttatatg ctgccgaagg ccaaaggtta atgcaggaaa gagaggttcc agaatatctt
       790        800        810        820        830        840
aaccatgtaa gtaaacgctt agaggaagag ggagacagag taatcactta cttggaccac
       850        860        870        880        890        900
agcacacaga aaccactgat tgcttgtgtg gagaaacagc tattaggaga acatttaaca
       910        920        930        940        950        960
gcaattctgc agaaagggct cgaccactta ctggatgaga acagagtgcc ggacctcgca
       970        980        990       1000       1010       1020
cagatgtacc agctgttcag ccgggtgagg ggcgggcagc aggcgctgct gcagcactgg
      1030       1040       1050       1060       1070       1080
agcgagtaca tcaagacttt tggaacagcg atcgtaatca atcctgagaa agacaaagac
      1090       1100       1110       1120       1130       1140
atggtccaag acctgttgga cttcaaggac aaggtggacc acgtgatcga ggtctgcttc
      1150       1160       1170       1180       1190       1200
cagaagaatg agcggttcgt caacctgatg aaggagtcct ttgagacgtt catcaacaag
      1210       1220       1230       1240       1250       1260
agacccaaca agcctgcaga actgatcgca aagcatgtgg attcaaagtt aagagcaggc
      1270       1280       1290       1300       1310       1320
aacaaagaag ccacagacga ggagctggag cggacgttgg acaagatcat gatcctgttc
      1330       1340       1350       1360       1370       1380
aggtttatcc acggtaaaga tgtctttgaa gcattttata aaaaagattt ggcaaaaaga
      1390       1400       1410       1420       1430       1440
ctccttgttg ggaaaagtgc ctcagtcgat gctgaaaagt ctatgttgtc aaagctcaag
      1450       1460       1470       1480       1490       1500
catgagtgcg gtgcagcctt caccagcaag ctggaaggca tgttcaagga catggagctt
      1510       1520       1530       1540       1550       1560
tcgaaggaca tcatggttca tttcaagcag catatgcaga atcagagtga ctcaggccct
      1570       1580       1590       1600       1610       1620
atagacctca cagtgaacat actcacaatg ggctactggc caacatacac gcccatggaa
      1630       1640       1650       1660       1670       1680
gtgcacttaa ccccagaaat gattaaactt caggaagtat ttaaggcatt ttatcttgga
      1690       1700       1710       1720       1730       1740
aagcacagtg gtcgaaaact tcagtggcaa actactttgg gacatgctgt tttaaaagcg
      1750       1760       1770       1780       1790       1800
gagtttaaag aagggaagaa ggaattccag gtgtccctct tccagacact ggtgctcctc
      1810       1820       1830       1840       1850       1860
atgttcaacg agggagatgg cttcagcttt gaggagataa aaatggccac ggggatagag
      1870       1880       1890       1900       1910       1920
gatagtgaat tgcgcagaac gctgcagtcc ctggcctgtg gcaaagcacg tgtgctgatt
      1930       1940       1950       1960       1970       1980
aaaagtccca aaggaaagga agtggaagat ggagacaagt tcatttttaa tggagagttc
      1990       2000       2010       2020       2030       2040
aagcacaagt tgtttagaat aaagatcaat caaattcaga tgaaggaaac tgttgaggaa
      2050       2060       2070       2080       2090       2100
caggttagca ccactgagag agtgtttcag gatagacaat atcagattga tgctgctatc
      2110       2120       2130       2140       2150       2160
gtcagaataa tgaagatgag aaagactctt ggtcataatc ttctagtttc tgaattatat
      2170       2180       2190       2200       2210       2220
aatcagctga aatttccagt aaagcctgga gatttgaaaa agagaattga atctctgata
      2230       2240       2250       2260       2270       2280
gacagagact atatggagag agacaaagac aatccgaatc agtaccacta cgtggcctga

Last modification date: Oct. 2, 2011