Homo sapiens L. (human) [HSA]

FULL NAME: Cullin-4B


DESCRIPTION:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

STRUCTURE SIMILARITY:
Belongs to the cullin family.


POST-TRANSLATIONAL MODIFICATION:
Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MFPTGFSSPS PSAAAAAQEV RSATDGNTST TPPTSAKKRK LNSSSSSSSN SSNEREDFDS
        70         80         90        100        110        120
TSSSSSTPPL QPRDSASPST SSFCLGVSVA ASSHVPIQKK LRFEDTLEFV GFDAKMAEES
       130        140        150        160        170        180
SSSSSSSSPT AATSQQQQLK NKSILISSVA SVHHANGLAK SSTTVSSFAN SKPGSAKKLV
       190        200        210        220        230        240
IKNFKDKPKL PENYTDETWQ KLKEAVEAIQ NSTSIKYNLE ELYQAVENLC SYKISANLYK
       250        260        270        280        290        300
QLRQICEDHI KAQIHQFRED SLDSVLFLKK IDRCWQNHCR QMIMIRSIFL FLDRTYVLQN
       310        320        330        340        350        360
SMLPSIWDMG LELFRAHIIS DQKVQNKTID GILLLIERER NGEAIDRSLL RSLLSMLSDL
       370        380        390        400        410        420
QIYQDSFEQR FLEETNRLYA AEGQKLMQER EVPEYLHHVN KRLEEEADRL ITYLDQTTQK
       430        440        450        460        470        480
SLIATVEKQL LGEHLTAILQ KGLNNLLDEN RIQDLSLLYQ LFSRVRGGVQ VLLQQWIEYI
       490        500        510        520        530        540
KAFGSTIVIN PEKDKTMVQE LLDFKDKVDH IIDICFLKNE KFINAMKEAF ETFINKRPNK
       550        560        570        580        590        600
PAELIAKYVD SKLRAGNKEA TDEELEKMLD KIMIIFRFIY GKDVFEAFYK KDLAKRLLVG
       610        620        630        640        650        660
KSASVDAEKS MLSKLKHECG AAFTSKLEGM FKDMELSKDI MIQFKQYMQN QNVPGNIELT
       670        680        690        700        710        720
VNILTMGYWP TYVPMEVHLP PEMVKLQEIF KTFYLGKHSG RKLQWQSTLG HCVLKAEFKE
       730        740        750        760        770        780
GKKELQVSLF QTLVLLMFNE GEEFSLEEIK QATGIEDGEL RRTLQSLACG KARVLAKNPK
       790        800        810        820        830        840
GKDIEDGDKF ICNDDFKHKL FRIKINQIQM KETVEEQAST TERVFQDRQY QIDAAIVRIM
       850        860        870        880        890
KMRKTLSHNL LVSEVYNQLK FPVKPADLKK RIESLIDRDY MERDKENPNQ YNYIA

Encoded by CUL4B gene

FULL NAME: cullin 4B


OTHER NAME(S):
DKFZp686F1470
KIAA0695
MRXHF2
MRXSC
SFM2
MRXS15


DESCRIPTION:
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtttccaa caggtttttc ttcccccagt ccctcagctg ctgctgctgc tcaggaggtc
        70         80         90        100        110        120
agatctgcca ctgatggtaa taccagcacc actccgccca cctctgccaa gaagagaaag
       130        140        150        160        170        180
ttaaacagca gcagcagtag cagcagtaac agtagtaacg agagagaaga ctttgattcc
       190        200        210        220        230        240
acctcttcct cctcttccac tcctccttta caacccaggg attcggcatc cccttcaacc
       250        260        270        280        290        300
tcgtccttct gcctgggggt ttcagtggct gcttccagcc acgtaccgat acagaagaag
       310        320        330        340        350        360
ctgcgttttg aagacaccct ggagtttgta gggtttgatg cgaagatggc tgaggaatcc
       370        380        390        400        410        420
tcctcctcct cctcctcatc ttcaccaact gctgcaacat ctcagcagca gcaacttaaa
       430        440        450        460        470        480
aataagagta tattaatctc ttctgtggct tcggtgcatc atgcaaacgg cctagccaaa
       490        500        510        520        530        540
tcttctacca ccgtctctag ctttgctaac agcaaacctg gctctgctaa gaagttagtg
       550        560        570        580        590        600
atcaagaact ttaaagataa gcctaaatta ccagaaaact acacagatga aacctggcaa
       610        620        630        640        650        660
aaactgaaag aagcagtgga agctattcag aatagtactt caattaagta caatttagaa
       670        680        690        700        710        720
gaactctacc aggctgtaga aaatctctgt tcttacaaga tttctgcaaa cttgtacaaa
       730        740        750        760        770        780
cagctgagac agatctgcga agatcacatc aaagcacaga ttcatcaatt cagagaggat
       790        800        810        820        830        840
tcattggata gcgttctttt tttaaagaag attgatagat gctggcaaaa ccattgcaga
       850        860        870        880        890        900
caaatgatca tgatcaggag catttttttg tttctggata gaacttacgt tcttcagaat
       910        920        930        940        950        960
tcaatgctac cctccatttg ggacatggga ctggagttat ttagggctca tattataagt
       970        980        990       1000       1010       1020
gatcagaaag tgcagaataa gacaattgat ggcattcttc tcttgattga gagggaaagg
      1030       1040       1050       1060       1070       1080
aatggtgaag caattgatag aagtttactt cgaagccttt taagcatgct gtctgatttg
      1090       1100       1110       1120       1130       1140
caaatttatc aagattcttt tgaacaacga tttttggaag aaactaaccg gctctatgca
      1150       1160       1170       1180       1190       1200
gctgaaggcc aaaaattaat gcaagaaaga gaggttcctg aatatctaca tcatgttaac
      1210       1220       1230       1240       1250       1260
aaacgtctag aagaagaagc agacagactt attacttact tagatcagac cacccagaag
      1270       1280       1290       1300       1310       1320
tcattaattg ctactgtaga aaaacaactt ctaggtgaac acttaacagc aattcttcag
      1330       1340       1350       1360       1370       1380
aaaggtttaa ataacctcct tgatgaaaac cgaattcaag atttgtctct tctgtatcag
      1390       1400       1410       1420       1430       1440
ctcttcagta gagttcgagg tggagttcag gttcttttgc agcagtggat cgaatatatc
      1450       1460       1470       1480       1490       1500
aaggcatttg gcagcactat tgtaattaat cctgaaaaag ataaaaccat ggttcaagaa
      1510       1520       1530       1540       1550       1560
ttgctggatt ttaaagataa ggttgaccat ataattgata tctgctttct gaagaatgag
      1570       1580       1590       1600       1610       1620
aaatttatca atgccatgaa agaagcattt gaaacgttca ttaacaaaag accaaataaa
      1630       1640       1650       1660       1670       1680
ccagctgaac ttatagctaa gtatgtagat tcaaaacttc gtgcaggcaa caaagaagct
      1690       1700       1710       1720       1730       1740
acagatgaag aacttgagaa aatgttggat aaaattatga tcatatttag atttatctat
      1750       1760       1770       1780       1790       1800
ggcaaggatg tttttgaggc cttctataag aaagatttag ccaagcgcct gttagtcgga
      1810       1820       1830       1840       1850       1860
aagagtgcat ctgtagatgc tgaaaaatca atgctgtcca aacttaaaca tgaatgcgga
      1870       1880       1890       1900       1910       1920
gctgctttca ccagcaaact tgaaggaatg tttaaagaca tggaactttc taaagacatc
      1930       1940       1950       1960       1970       1980
atgattcagt tcaaacagta tatgcagaat cagaatgttc cgggaaatat tgagttaact
      1990       2000       2010       2020       2030       2040
gtgaatatcc tgacaatggg ctattggccg acatatgtgc ctatggaagt tcatttacca
      2050       2060       2070       2080       2090       2100
ccagagatgg taaaacttca ggagattttc aagacatttt acctaggcaa acatagtggc
      2110       2120       2130       2140       2150       2160
aggaaacttc agtggcagtc aaccctagga cactgtgtgt taaaagcaga atttaaagag
      2170       2180       2190       2200       2210       2220
ggtaaaaagg aactccaggt ctctcttttt caaacactgg tgctgctaat gtttaatgag
      2230       2240       2250       2260       2270       2280
ggagaggagt tcagtttaga agagatcaag caggcaactg gaatagagga tggagagtta
      2290       2300       2310       2320       2330       2340
aggagaacac tgcagtcatt agcctgtggc aaagctagag ttctggcgaa aaatccaaag
      2350       2360       2370       2380       2390       2400
ggcaaagaca ttgaagatgg tgacaagttc atttgtaatg atgatttcaa acataaactt
      2410       2420       2430       2440       2450       2460
ttcaggataa agatcaatca aatccagatg aaagaaacgg ttgaagaaca agcaagcact
      2470       2480       2490       2500       2510       2520
acagaaagag tatttcaaga cagacagtat caaattgatg ctgcaattgt tcgaattatg
      2530       2540       2550       2560       2570       2580
aagatgagaa agacacttag ccacaatctc cttgtttcag aagtgtacaa ccagttgaaa
      2590       2600       2610       2620       2630       2640
tttccagtaa agcctgctga tcttaagaag agaatagaat ctttaattga ccgggactac
      2650       2660       2670       2680
atggaaagag ataaagaaaa tccaaaccag tacaactata ttgcatag 

Last modification date: Oct. 2, 2011