Homo sapiens L. (human) [HSA]

FULL NAME: E3 ubiquitin-protein ligase RBX1


DESCRIPTION:
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

STRUCTURE SIMILARITY:
Contains 1 RING-type zinc finger.
Belongs to the RING-box family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ
        70         80         90        100
ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH 

Encoded by RBX1 gene

FULL NAME: ring-box 1, E3 ubiquitin protein ligase


OTHER NAME(S):
BA554C12.1
FLJ60363
MGC13357
MGC1481
RNF75
ROC1


DESCRIPTION:
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggcag cgatggatgt ggataccccg agcggcacca acagcggcgc gggcaagaag
        70         80         90        100        110        120
cgctttgaag tgaaaaagtg gaatgcagta gccctctggg cctgggatat tgtggttgat
       130        140        150        160        170        180
aactgtgcca tctgcaggaa ccacattatg gatctttgca tagaatgtca agctaaccag
       190        200        210        220        230        240
gcgtccgcta cttcagaaga gtgtactgtc gcatggggag tctgtaacca tgcttttcac
       250        260        270        280        290        300
ttccactgca tctctcgctg gctcaaaaca cgacaggtgt gtccattgga caacagagag
       310        320
tgggaattcc aaaagtatgg gcactag   

Last modification date: Oct. 2, 2011