Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA ligase


STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


PROTEIN TYPE(S):
DNA ligase


RELATED PATHWAY(S):
microhomology-mediated end-joining (MMEJ)
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MLLSRLTWQA RILTRLLCNK MASKGLHNED NKLDTFRRIC DEIAGESSYL KKAERLQRFF
        70         80         90        100        110        120
EKGSSGKGFK GDTVLWVQFL IPAANQRVYN LQNKALIKLF SRIFNADQQQ MHLDLEQDGD
       130        140        150        160        170        180
VSETLRKHFA ASKKLKPQKQ SKLYLQEVEE MLLHLVERTK EDEQTDLLQK LCSKATDLDL
       190        200        210        220        230        240
RTFIRLVKHD LRINARARHI LDAFGPDAYP AYQSSRDLVA IVEQFATKEN KNYASSPVKK
       250        260        270        280        290        300
TKKTSSSAIQ VMTPISPMLA SPCKSVEDAF KKSPTGLYSE IKYDGERVQI HKQGNDFKFF
       310        320        330        340        350        360
SRNLKPVVDH KIRALKKYIP QAFPGGGEMI LDSEIILVDT DTGALLPFGS LGAHKKQTFA
       370        380        390        400        410        420
NAAVCLFVFD CILYDGEDLT QLPFRKRREI LEQNIQPIKS HVQLSESEFL KTTRELAAMT
       430        440        450        460        470        480
ARVLHANLEG VVLKSPTSTY QPGKRNWLKV KKDYLFDGKM ADTADLVVLG AWYGSGKKGG
       490        500        510        520        530        540
TLSIFLMGCY DAFGRLWKTV TKVHSGLDDA TNAEVHKSLI KLTERADANA IPSWLLCSKS
       550        560        570        580        590        600
LVPDVLAKDP MKMPVWEITG AEFTKSDAHT ASGISVRFPR ITRRRSDKSA KEANDLAHLE
       610        620        630        640        650        660
DLFEASKSNV NVDLLLANCS KDETAMNNKT TPEKEKKLNG NQSNGSKKLK RSNTGSDDED
       670        680        690        700        710        720
GAPVLSKRKE SKAIRSLSPS QKGLKDFFKP SKEFKSVVKK EPKEDEGNIE STSSKPQLFE
       730        740        750        760        770        780
GLVAHFAMEK DSSKLMQQFS QHGGCCTTEP QKADLVFYAN TNEALDLEKL RTLYRRSCRH
       790        800
LNVSWLQSCL DTQSRQPFPL HAVMMK   

Encoded by lig3 gene

FULL NAME: DNA ligase III


OTHER NAME(S):
CG17227
Dmel\CG17227
LIG3


Nucleic acid sequence

        10         20         30         40         50         60
atgctattgt ccaggctaac gtggcaggcc aggattctaa ctcgtcttct gtgtaataag
        70         80         90        100        110        120
atggccagca agggattgca caatgaggac aacaagttgg acactttccg tcgcatctgt
       130        140        150        160        170        180
gatgaaattg ccggcgagtc aagttacctg aagaaagcgg agagactgca gcgattcttc
       190        200        210        220        230        240
gaaaagggga gcagtggcaa gggcttcaag ggcgacaccg tgctctgggt gcagttcctc
       250        260        270        280        290        300
attccggcgg ccaatcagcg cgtctacaat ctgcagaaca aggcgctgat caaactcttt
       310        320        330        340        350        360
tcgcgcattt ttaatgcaga tcaacagcaa atgcatctgg atctagagca ggatggcgac
       370        380        390        400        410        420
gtttcggaaa ctctacgcaa gcactttgct gcttctaaga aactcaagcc gcaaaagcag
       430        440        450        460        470        480
agcaaactct atctgcagga ggtggaggaa atgctcctgc acctggtgga gcgtaccaaa
       490        500        510        520        530        540
gaggatgagc aaacagatct gctacagaag ttgtgctcga aggccactga cctggatctg
       550        560        570        580        590        600
cgcaccttta ttcgcttggt gaagcacgac ttaagaatca atgcccgagc ccggcacatc
       610        620        630        640        650        660
ctggatgctt ttggtcctga tgcctacccc gcatatcagt cttcccgcga tttggtggca
       670        680        690        700        710        720
attgtcgaac agtttgccac caaagaaaat aaaaattatg ctagtagtcc cgttaagaag
       730        740        750        760        770        780
actaagaaaa cgagctcgag tgcaattcag gtaatgacac ccatatcgcc catgttggcc
       790        800        810        820        830        840
agtccctgca agtcggtgga ggacgccttc aagaagagcc ccactggact atatagcgag
       850        860        870        880        890        900
atcaaatacg atggagagcg agttcaaatc cacaagcagg gcaacgactt caagttcttt
       910        920        930        940        950        960
agtcgcaatc taaagcctgt ggtggatcac aagatacggg ctctgaaaaa atatattccg
       970        980        990       1000       1010       1020
caagcctttc ctggcggtgg cgaaatgata ctggactctg agatcattct ggtcgacact
      1030       1040       1050       1060       1070       1080
gacacaggag cactgctgcc ctttggttcg ttgggtgccc ataagaagca gactttcgcc
      1090       1100       1110       1120       1130       1140
aatgctgctg tatgcttatt cgtcttcgat tgcatactgt atgatggcga ggatttgacc
      1150       1160       1170       1180       1190       1200
cagctgccat ttcgcaagcg tcgcgagatt cttgagcaga atattcaacc cattaaatcc
      1210       1220       1230       1240       1250       1260
cacgtgcagc tgtcggagtc ggagttcctc aagaccacga gggaactggc cgcgatgacg
      1270       1280       1290       1300       1310       1320
gccagggtgt tacatgccaa tctggagggt gtggtcctaa agagtccaac cagcacatat
      1330       1340       1350       1360       1370       1380
cagcccggca aaaggaactg gcttaaggtc aagaaggatt acctattcga cggaaagatg
      1390       1400       1410       1420       1430       1440
gctgacaccg cggacttggt tgttttgggt gcttggtacg gatcagggaa gaaaggtggc
      1450       1460       1470       1480       1490       1500
acgcttagta tttttctcat gggctgctac gatgcgtttg ggcgtttgtg gaagacagtg
      1510       1520       1530       1540       1550       1560
accaaagtgc actctggctt ggatgatgct accaacgcag aggtacataa atcactaatc
      1570       1580       1590       1600       1610       1620
aaactaaccg aacgtgctga tgccaacgca attcccagtt ggctgttatg cagtaagtcc
      1630       1640       1650       1660       1670       1680
cttgtaccag atgtactggc caaggatccg atgaaaatgc cagtatggga gattactggc
      1690       1700       1710       1720       1730       1740
gcagagttca ccaagtccga tgcccatacc gcgtctggaa tctcagtacg atttcccagg
      1750       1760       1770       1780       1790       1800
attactcgtc gtcgcagtga taaatcagcc aaagaggcca atgatctggc ccatctagaa
      1810       1820       1830       1840       1850       1860
gatcttttcg aggcctcaaa atcgaatgta aatgttgatt tacttctggc caattgtagt
      1870       1880       1890       1900       1910       1920
aaagatgaga cagcaatgaa taacaaaaca actcctgaaa aggagaaaaa actgaatggc
      1930       1940       1950       1960       1970       1980
aatcaatcaa atggtagtaa gaaattgaaa aggtccaata ctggttctga tgacgaagac
      1990       2000       2010       2020       2030       2040
ggagctcctg tgctcagcaa acgcaaggag tccaaagcga ttcgaagctt gtccccttcg
      2050       2060       2070       2080       2090       2100
caaaagggat taaaggattt ttttaagccc agcaaggagt ttaaatcagt tgtgaaaaag
      2110       2120       2130       2140       2150       2160
gaaccaaagg aggatgaagg caatattgaa tccactagct cgaaacccca gttgttcgaa
      2170       2180       2190       2200       2210       2220
ggattggtgg cacactttgc catggagaag gattcaagta aactgatgca gcagttttca
      2230       2240       2250       2260       2270       2280
cagcatggag gatgctgtac aacagaacca caaaaagctg atctggtctt ttatgcgaat
      2290       2300       2310       2320       2330       2340
acgaacgagg cattggacct agagaagctt agaacgctct atcgtcgtag ctgccggcac
      2350       2360       2370       2380       2390       2400
ttgaatgtaa gctggctcca aagctgtctc gatactcaga gtcgtcaacc ttttccccta
      2410       2420
cacgccgtga tgatgaaatg a   

Last modification date: Oct. 2, 2011