Homo sapiens L. (human) [HSA]

FULL NAME: DNA2-like helicase


DESCRIPTION:
May function in chromosomal DNA replication (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA2/NAM7 helicase family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MKTPCIPSPK QGSKGRGQSP AAQVRGPTWN APAREGRPGA GHLGHLRVGA CARGAQARAF
        70         80         90        100        110        120
FPFLSFLCYP RFRCLFCLQF AIPASRMEQL NELELLMEKS FWEEAELPAE LFQKKVVASF
       130        140        150        160        170        180
PRTVLSTGMD NRYLVLAVNT VQNKEGNCEK RLVITASQSL ENKELCILRN DWCSVPVEPG
       190        200        210        220        230        240
DIIHLEGDCT SDTWIIDKDF GYLILYPDML ISGTSIASSI RCMRRAVLSE TFRSSDPATR
       250        260        270        280        290        300
QMLIGTVLHE VFQKAINNSF APEKLQELAF QTIQEIRHLK EMYRLNLSQD EIKQEVEDYL
       310        320        330        340        350        360
PSFCKWAGDF MHKNTSTDFP QMQLSLPSDN SKDNSTCNIE VVKPMDIEES IWSPRFGLKG
       370        380        390        400        410        420
KIDVTVGVKI HRGYKTKYKI MPLELKTGKE SNSIEHRSQV VLYTLLSQER RADPEAGLLL
       430        440        450        460        470        480
YLKTGQMYPV PANHLDKREL LKLRNQMAFS LFHRISKSAT RQKTQLASLP QIIEEEKTCK
       490        500        510        520        530        540
YCSQIGNCAL YSRAVEQQMD CSSVPIVMLP KIEEETQHLK QTHLEYFSLW CLMLTLESQS
       550        560        570        580        590        600
KDNKKNHQNI WLMPASEMEK SGSCIGNLIR MEHVKIVCDG QYLHNFQCKH GAIPVTNLMA
       610        620        630        640        650        660
GDRVIVSGEE RSLFALSRGY VKEINMTTVT CLLDRNLSVL PESTLFRLDQ EEKNCDIDTP
       670        680        690        700        710        720
LGNLSKLMEN TFVSKKLRDL IIDFREPQFI SYLSSVLPHD AKDTVACILK GLNKPQRQAM
       730        740        750        760        770        780
KKVLLSKDYT LIVGMPGTGK TTTICTLVRI LYACGFSVLL TSYTHSAVDN ILLKLAKFKI
       790        800        810        820        830        840
GFLRLGQIQK VHPAIQQFTE QEICRSKSIK SLALLEELYN SQLIVATTCM GINHPIFSRK
       850        860        870        880        890        900
IFDFCIVDEA SQISQPICLG PLFFSRRFVL VGDHQQLPPL VLNREARALG MSESLFKRLE
       910        920        930        940        950        960
QNKSAVVQLT VQYRMNSKIM SLSNKLTYEG KLECGSDKVA NAVINLRHFK DVKLELEFYA
       970        980        990       1000       1010       1020
DYSDNPWLMG VFEPNNPVCF LNTDKVPAPE QVEKGGVSNV TEAKLIVFLT SIFVKAGCSP
      1030       1040       1050       1060       1070       1080
SDIGIIAPYR QQLKIINDLL ARSIGMVEVN TVDKYQGRDK SIVLVSFVRS NKDGTVGELL
      1090       1100       1110       1120       1130       1140
KDWRRLNVAI TRAKHKLILL GCVPSLNCYP PLEKLLNHLN SEKLIIDLPS REHESLCHIL

GDFQRE     

Encoded by DNA2 gene

FULL NAME: DNA replication helicase 2 homolog (yeast)


OTHER NAME(S):
DNA2L
FLJ10063
KIAA0083
MGC133297


DESCRIPTION:
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atgaagactc cctgtattcc cagtcctaag caagggagca aaggcagggg acagagccct
        70         80         90        100        110        120
gctgctcagg tgaggggccc cacgtggaac gcgccggcgc gggaggggcg gcctggcgca
       130        140        150        160        170        180
ggtcatttgg gacatctgcg ggttggcgca tgcgcgcgag gtgcgcaggc tcgcgccttt
       190        200        210        220        230        240
ttcccttttc taagctttct gtgttacccc cggttccgct gtcttttctg tctacagttt
       250        260        270        280        290        300
gcgatccccg cgtccaggat ggagcagctg aacgaactgg agctgctgat ggagaagagt
       310        320        330        340        350        360
ttttgggagg aggcggagct gccggcggag ctatttcaga agaaagtggt agcttccttt
       370        380        390        400        410        420
ccaagaacag ttctgagcac aggaatggat aaccggtacc tggtgttggc agtcaatact
       430        440        450        460        470        480
gtacagaaca aagagggaaa ctgtgaaaag cgcctggtca tcactgcttc acagtcacta
       490        500        510        520        530        540
gaaaataaag aactatgcat ccttaggaat gactggtgtt ctgttccagt agagccagga
       550        560        570        580        590        600
gatatcattc atttggaggg agactgcaca tctgacactt ggataataga taaagatttt
       610        620        630        640        650        660
ggatatttga ttctgtatcc agacatgctg atttctggca ccagcatagc cagtagtatt
       670        680        690        700        710        720
cgatgtatga gaagagctgt cctgagtgaa acttttagga gctctgatcc agccacacgc
       730        740        750        760        770        780
caaatgctaa ttggtacggt tctccatgag gtgtttcaaa aagccataaa taatagcttt
       790        800        810        820        830        840
gccccagaaa agctacaaga acttgctttt caaacaattc aagaaataag acatttgaag
       850        860        870        880        890        900
gaaatgtacc gcttaaatct aagtcaagat gaaataaaac aagaagtaga ggactatctt
       910        920        930        940        950        960
ccttcgtttt gtaaatgggc aggagatttc atgcataaaa acacttcgac tgacttccct
       970        980        990       1000       1010       1020
cagatgcagc tctctctgcc aagtgataat agtaaggata attcaacatg taacattgaa
      1030       1040       1050       1060       1070       1080
gtcgtgaaac caatggatat tgaagaaagc atttggtccc ctaggtttgg attgaaaggc
      1090       1100       1110       1120       1130       1140
aaaatagatg ttacagttgg tgtgaaaata catcgagggt ataaaacaaa atacaagata
      1150       1160       1170       1180       1190       1200
atgccgctgg aacttaaaac tggcaaagaa tcaaattcta ttgaacaccg tagtcaggtt
      1210       1220       1230       1240       1250       1260
gttctgtaca ctctactaag ccaagagaga agagctgatc cagaggctgg cttgcttctc
      1270       1280       1290       1300       1310       1320
tacctcaaga ctggtcagat gtaccctgtg cctgccaacc atctagataa aagagaatta
      1330       1340       1350       1360       1370       1380
ttaaagctaa gaaaccagat ggcattctca ttgtttcacc gtattagcaa atctgctact
      1390       1400       1410       1420       1430       1440
agacagaaga cacagcttgc ttctttgcca caaataattg aggaagagaa aacttgtaaa
      1450       1460       1470       1480       1490       1500
tattgttcac aaattggcaa ttgtgctctt tatagcagag cagttgaaca acagatggat
      1510       1520       1530       1540       1550       1560
tgtagttcag tcccaattgt gatgctgccc aaaatagaag aagaaaccca gcatctgaag
      1570       1580       1590       1600       1610       1620
caaacacact tagaatattt cagcctttgg tgtctaatgt taaccctgga gtcacaatcg
      1630       1640       1650       1660       1670       1680
aaggataata aaaagaatca ccaaaatatc tggctaatgc ctgcttcgga aatggagaag
      1690       1700       1710       1720       1730       1740
agtggcagtt gcattggaaa cctgattaga atggaacatg taaagatagt ttgtgatggg
      1750       1760       1770       1780       1790       1800
caatatttac ataatttcca atgtaaacat ggtgccatac ctgtcacaaa tctaatggca
      1810       1820       1830       1840       1850       1860
ggtgacagag ttattgtaag tggagaagaa aggtcactgt ttgctttgtc tagaggatat
      1870       1880       1890       1900       1910       1920
gtgaaggaga ttaacatgac aacagtaact tgtttattag acagaaactt gtcggtcctt
      1930       1940       1950       1960       1970       1980
ccagaatcaa ctttgttcag attagaccaa gaagaaaaaa attgtgatat agatacccca
      1990       2000       2010       2020       2030       2040
ttaggaaatc tttccaaatt gatggaaaac acgtttgtca gcaaaaaact tcgagattta
      2050       2060       2070       2080       2090       2100
attattgact ttcgtgaacc tcagtttata tcctacctta gttctgttct tccacatgat
      2110       2120       2130       2140       2150       2160
gcaaaggata cagttgcctg cattctaaag ggtttgaata agcctcagag gcaagcgatg
      2170       2180       2190       2200       2210       2220
aaaaaggtac ttctttcaaa agactacaca ctcatcgtgg gtatgcctgg gacaggaaaa
      2230       2240       2250       2260       2270       2280
acaactacga tatgtactct cgtaagaatt ctctacgcct gtggttttag cgttttgttg
      2290       2300       2310       2320       2330       2340
accagctata cacactctgc tgttgacaat attcttttga agttagccaa gtttaaaata
      2350       2360       2370       2380       2390       2400
ggatttttgc gtttgggtca gattcagaag gttcatccag ctatccagca atttacagag
      2410       2420       2430       2440       2450       2460
caagaaattt gcagatcaaa gtccattaaa tccttagctc ttctagaaga actctacaat
      2470       2480       2490       2500       2510       2520
agtcaactta tagttgcaac aacatgtatg ggaataaacc atccaatatt ttcccgtaaa
      2530       2540       2550       2560       2570       2580
atttttgatt tttgtattgt ggatgaagcc tctcaaatta gccaaccaat ttgtctgggc
      2590       2600       2610       2620       2630       2640
cccctttttt tttcacggag atttgtgtta gtgggggacc atcagcagct tcctcccctg
      2650       2660       2670       2680       2690       2700
gtgctaaacc gtgaagcaag agctcttggc atgagtgaaa gcttattcaa gaggctggag
      2710       2720       2730       2740       2750       2760
cagaataaga gtgctgttgt acagttaacc gtgcagtaca gaatgaacag taaaattatg
      2770       2780       2790       2800       2810       2820
tccttaagta ataagctgac ctatgagggc aagctggagt gtggatcaga caaagtggcc
      2830       2840       2850       2860       2870       2880
aatgcagtga taaacctacg tcactttaaa gatgtgaagc tggaactgga attttatgct
      2890       2900       2910       2920       2930       2940
gactattctg ataatccttg gttgatggga gtatttgaac ccaacaatcc tgtttgtttc
      2950       2960       2970       2980       2990       3000
cttaatacag acaaggttcc agcgccagaa caagttgaaa aaggtggtgt gagcaatgta
      3010       3020       3030       3040       3050       3060
acagaagcca aactcatagt tttcctaacc tccatttttg ttaaggctgg atgcagtccc
      3070       3080       3090       3100       3110       3120
tctgatattg gtattattgc accgtacagg cagcaattaa agatcatcaa tgatttattg
      3130       3140       3150       3160       3170       3180
gcacgttcta ttgggatggt cgaagttaat acagtagaca aataccaagg aagggacaaa
      3190       3200       3210       3220       3230       3240
agtattgtcc tagtatcttt tgttagaagt aataaggatg gaactgttgg tgaactcttg
      3250       3260       3270       3280       3290       3300
aaagattggc gacgtcttaa tgttgctata accagagcca aacataaact gattcttctg
      3310       3320       3330       3340       3350       3360
gggtgtgtgc cctcactaaa ttgctatcct cctttggaga agctgcttaa tcatttaaac
      3370       3380       3390       3400       3410       3420
tcagaaaaat taatcattga tcttccatca agagaacatg aaagtctttg ccacatattg
      3430       3440
ggtgactttc aaagagaata a   

Last modification date: Oct. 2, 2011