Mus musculus L. (mouse) [MMU]

FULL NAME: DNA ligase


STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


PROTEIN TYPE(S):
DNA ligase


RELATED PATHWAY(S):
microhomology-mediated end-joining (MMEJ)
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MTLAFKILFP RNLCALGRKE LCLFPEQNRW AAISQFSQWS ETNLLGGCCL LQRRKPVLAL
        70         80         90        100        110        120
QRGHLRPRAT HLTFWPGSHV GLCTGPCAMA EQRFCVDYAK RGTAGCKKCK EKIVKGVCRI
       130        140        150        160        170        180
GKVVPNPFSE SGGDMKEWYH IKCMFEKLER ARATTKKIED LTELEGWEEL EDNEKEQISQ
       190        200        210        220        230        240
HIADLSSKAA ATPKKKAAVQ AKLTTTGQVT SPVKGASFIT STNPRKFSGF SAAKPNNSEQ
       250        260        270        280        290        300
APSSPAPGTS LSASKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIHD FLQKGSTGDG
       310        320        330        340        350        360
FHGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNP DDMARDLEQG DVSETIRIFF
       370        380        390        400        410        420
EQSKSFPPAA KSLLTIQEVD AFLLHLSKLT KEDEQQQALQ DIASRCTAND LKCIIRLIKH
       430        440        450        460        470        480
DLKMNSGAKH VLDALDPNAY EAFKASRNLQ DVVERVLHNE QEVEKDPGRR RALRVQASLM
       490        500        510        520        530        540
TPVQPMLAEA CKSIEYAMKK CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV
       550        560        570        580        590        600
AHFKDYIPKA FPGGQSMILD SEVLLIDNNT GKPLPFGTLG VHKKAAFQDA NVCLFVFDCI
       610        620        630        640        650        660
YFNDVSLMDR PLCERRKFLH DNMVEIRNRI MFSEMKQVTK ASDLADMINR VIREGLEGLV
       670        680        690        700        710        720
LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF YGQGSKGGMM SIFLMGCYDP
       730        740        750        760        770        780
DSQKWCTVTK CAGGHDDATL ARLQKELVMV KISKDPSKIP SWLKINKIYY PDFIVPDPKK
       790        800        810        820        830        840
AAVWEITGAE FSRSEAHTAD GISIRFPRCT RIRDDKDWKS ATNLPQLKEL YQLSKDKADF
       850        860        870        880        890        900
AVVAGDEASP TTGGSSGENE GTAGSAGPCK GPPSKSSASA KTTEQKLNSP SSRGGIKPIP
       910        920        930        940        950        960
KHSPMKPGEK LAVKSSPVKV GMKRKATDET PCLKKVLLDV FTGVRLYLPP STPDFKRLKR
       970        980        990       1000       1010
YFVAFDGDLV QEFDMGSATH VLGNREKNTD AQLVSSEWIW ACIRKRRLIA PC

Encoded by Lig3 gene

FULL NAME: ligase III, DNA, ATP-dependent


OTHER NAME(S):
D11Wsu78e
MGC78176


Nucleic acid sequence

        10         20         30         40         50         60
atgactttgg ctttcaagat cctcttcccg agaaaccttt gtgcccttgg cagaaaagaa
        70         80         90        100        110        120
ctgtgcctgt tcccagaaca gaatcgctgg gctgccataa gtcagttcag ccagtggtcg
       130        140        150        160        170        180
gaaacaaatc tcctcggtgg gtgctgcctt ctccagagaa gaaagcctgt cctagctctc
       190        200        210        220        230        240
cagagaggtc atctaagacc acgtgccacc caccttactt tctggccagg gtcgcatgtg
       250        260        270        280        290        300
ggactctgta ctggcccctg tgcgatggca gagcagcggt tctgtgtgga ctatgccaag
       310        320        330        340        350        360
cggggcacag ctggatgcaa gaaatgcaag gagaagattg taaagggcgt gtgccgcatt
       370        380        390        400        410        420
ggcaaagtgg tgcccaaccc cttctcagag tctgggggtg atatgaaaga gtggtaccac
       430        440        450        460        470        480
attaagtgca tgtttgagaa actggaacgg gctcgggcca ccacaaagaa aattgaagac
       490        500        510        520        530        540
ctcacagagc tggaaggctg ggaagagctg gaagataacg aaaaggaaca gataagccag
       550        560        570        580        590        600
catattgcag acctgtcttc taaggcagct gccacaccta agaagaaagc tgctgtccag
       610        620        630        640        650        660
gctaagctga caaccactgg ccaggtgaca tctccagtga aaggtgcttc gtttattacc
       670        680        690        700        710        720
agtaccaatc ctcggaagtt ctctggcttt tcagcagcaa aacccaacaa ctctgagcaa
       730        740        750        760        770        780
gccccctcaa gccctgctcc tggaacgagt ctgtctgcaa gtaaatgtga ccctaagcac
       790        800        810        820        830        840
aaagattgtc tgctacgaga gttccggaag ctgtgcgcca tggtggctga aaatcctagc
       850        860        870        880        890        900
tataacacca agacccagat catccatgac ttcttgcaga aaggctccac aggagatggc
       910        920        930        940        950        960
tttcacggtg atgtgtacct gacagttaag ctgctgctgc ctggtgtcat caagagtgtt
       970        980        990       1000       1010       1020
tacaacttga atgataagca gattgtaaaa ctttttagcc gaatttttaa ctgcaaccca
      1030       1040       1050       1060       1070       1080
gatgatatgg cccgggacct agaacagggt gacgtgtcag agacgatcag aatcttcttt
      1090       1100       1110       1120       1130       1140
gagcagagca agtctttccc cccagctgcc aaaagcctcc tcaccattca ggaagtggat
      1150       1160       1170       1180       1190       1200
gccttcctcc tgcacctctc caagctcacc aaagaggatg agcagcagca ggccctgcag
      1210       1220       1230       1240       1250       1260
gacatagcct cccggtgtac agccaatgac cttaagtgca ttattcggct gatcaaacat
      1270       1280       1290       1300       1310       1320
gatctgaaga tgaactcggg tgcaaaacac gtgttagatg cccttgaccc caatgcttat
      1330       1340       1350       1360       1370       1380
gaagccttca aagcatcgcg caacctgcag gatgtggtgg agcgagtcct tcacaatgag
      1390       1400       1410       1420       1430       1440
caggaggtgg agaaggaccc aggccggcga cgggctctga gggtccaggc ctcactgatg
      1450       1460       1470       1480       1490       1500
acgcctgtgc agcccatgct ggctgaggcc tgcaaatcca ttgaatatgc aatgaagaag
      1510       1520       1530       1540       1550       1560
tgtcccaatg gcatgttctc tgagatcaag tacgatggtg agcgagtcca ggtgcataag
      1570       1580       1590       1600       1610       1620
aagggggacc acttcagcta cttcagccgc agtctcaagc ctgtcctgcc tcacaaggtg
      1630       1640       1650       1660       1670       1680
gcccacttca aggactatat acccaaagct tttcctgggg gtcaaagcat gatcttggat
      1690       1700       1710       1720       1730       1740
tccgaggtac tcctgattga caacaacaca ggcaaaccac tgccctttgg gactctggga
      1750       1760       1770       1780       1790       1800
gtgcacaaga aagctgcttt ccaggatgct aatgtctgcc tgtttgtttt tgattgtatc
      1810       1820       1830       1840       1850       1860
tactttaatg atgtcagctt gatggacagg cctctctgtg agcgacggaa gtttcttcat
      1870       1880       1890       1900       1910       1920
gacaacatgg ttgaaatccg taaccggatc atgttctcag aaatgaagca agtcacaaaa
      1930       1940       1950       1960       1970       1980
gcttcagacc tggctgacat gataaaccgg gtgatccgag agggcttgga agggttggtg
      1990       2000       2010       2020       2030       2040
ctaaaggatg tgaagggtac atatgagcct gggaagcggc actggctgaa agttaagaaa
      2050       2060       2070       2080       2090       2100
gattatttga atgagggggc catggctgat acagctgatc tggtggttct tggggccttc
      2110       2120       2130       2140       2150       2160
tatgggcaag ggagcaaagg cggaatgatg tccatcttcc tcatgggctg ctatgaccct
      2170       2180       2190       2200       2210       2220
gacagccaaa agtggtgcac tgttacaaaa tgtgctggag gccatgatga tgccacactt
      2230       2240       2250       2260       2270       2280
gcccgcctgc agaaagagct ggttatggtg aagatcagca aggatcctag taagataccc
      2290       2300       2310       2320       2330       2340
agctggctga agatcaacaa gatctattat cctgacttta tcgtcccaga cccaaagaaa
      2350       2360       2370       2380       2390       2400
gctgctgtgt gggagatcac aggggcagaa ttctccagat ctgaggcaca cactgctgat
      2410       2420       2430       2440       2450       2460
ggcatctcca tccgatttcc tcgatgcacc cgaatccggg acgacaagga ctggaaatct
      2470       2480       2490       2500       2510       2520
gccactaacc tcccccaact caaggaactg taccagctgt ccaaagacaa ggcagacttt
      2530       2540       2550       2560       2570       2580
gctgtggtgg ctggagatga ggcaagcccc actactggag gcagcagtgg cgagaacgag
      2590       2600       2610       2620       2630       2640
ggcactgctg ggtctgctgg gccctgcaag ggccccccca gtaagtcctc tgccagtgcc
      2650       2660       2670       2680       2690       2700
aagaccaccg aacagaagct caatagcccc agtagcagag gtggcatcaa accgattcca
      2710       2720       2730       2740       2750       2760
aagcattccc ccatgaaacc aggagagaag ctggctgtga agtcttctcc agtcaaagtg
      2770       2780       2790       2800       2810       2820
ggaatgaaga ggaaagctac tgatgagacc ccatgcctga aaaaggtact gttggatgtc
      2830       2840       2850       2860       2870       2880
ttcactgggg tgcggctcta cttgccacct tctacaccag acttcaaacg tctcaaacgc
      2890       2900       2910       2920       2930       2940
tactttgtgg cattcgacgg ggacctggta caggaatttg acatgggctc agccacacat
      2950       2960       2970       2980       2990       3000
gtgctaggta acagggaaaa gaacactgat gcccagttgg tctcctcaga gtggatttgg
      3010       3020       3030
gcatgtatcc ggaaacggag gctgatagct ccctgctag  

Last modification date: Oct. 2, 2011