Homo sapiens L. (human) [HSA]

Amino acids sequence

        10         20         30         40         50         60
MVLELNASDD RGIDIIRGPI LSFASTRTIF KKGFKLVILD EADAMTQDAQ NALRRVIEKF
        70         80         90        100        110        120
TENTRFCLIC NYLSKIIPAL QSRCTRFRFG PLTPELMVPR LEHVVEEEKV DISEDGMKAL
       130        140        150        160        170        180
VTLSSGDMRR ALNILQSTNM AFGKVTEETV YTCTGHPLKS DIANILDWML NQDFTTAYRN
       190        200        210        220        230        240
ITELKTLKGL ALHDILTEIH LFVHRVDFPS SVRIHLLTKM ADIEYRLSVG TNEKIQLSSL
       250
IAAFQVTRDL IVAEA    

Encoded by RFC5 gene

FULL NAME: replication factor C (activator 1) 5, 36.5kDa


OTHER NAME(S):
MGC1155
RFC36


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]


Nucleic acid sequence

        10         20         30         40         50         60
atggtcttgg agctgaatgc ttcagatgac cgaggaatag acatcattcg aggaccgatc
        70         80         90        100        110        120
ctgagctttg ctagcacaag gacaatattt aagaaaggct ttaagctagt gatcttggat
       130        140        150        160        170        180
gaagcagacg ccatgactca ggacgcccag aatgccttga gaagagtaat tgagaaattc
       190        200        210        220        230        240
acagaaaata ccagattctg cctcatctgt aactatctgt caaagatcat ccctgccttg
       250        260        270        280        290        300
cagtcccgct gcacgaggtt tcggttcggt cccctgactc ctgaactcat ggttccccgc
       310        320        330        340        350        360
ctggaacatg tcgtggaaga agagaaagtt gatataagtg aagatggaat gaaagcacta
       370        380        390        400        410        420
gtcactcttt ccagtggaga catgcgtagg gctctgaaca ttttgcagag caccaatatg
       430        440        450        460        470        480
gcctttggga aggtgacaga ggagactgtc tacacctgca ccgggcaccc gctcaagtca
       490        500        510        520        530        540
gacattgcca acatcctgga ctggatgttg aatcaagatt tcaccacagc ctacagaaat
       550        560        570        580        590        600
attacagagt tgaaaactct gaaggggttg gcactgcatg atatcctgac agagatacac
       610        620        630        640        650        660
ttgtttgtgc atagagttga ctttccatct tcagttcgaa tacatttatt gaccaaaatg
       670        680        690        700        710        720
gcagacattg agtacaggct ttctgttggc accaacgaga agatccagct gagctccctc
       730        740        750        760
attgctgcat ttcaagtcac cagagacctg attgttgcag aggcctag 

Last modification date: Oct. 2, 2011