Mus musculus L. (mouse) [MMU]

FULL NAME: High mobility group protein B1


DESCRIPTION:
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

STRUCTURE SIMILARITY:
Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF
        70         80         90        100        110        120
EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL
       130        140        150        160        170        180
SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK
       190        200        210
SKKKKEEEDD EEDEEDEEEE EEEEDEDEEE DDDDE  

Encoded by Hmgb1 gene

FULL NAME: high mobility group box 1


OTHER NAME(S):
DEF
HMG-1
Hmg1
MGC103168
MGC103169
MGC117896
MGC117897
SBP-1
amphoterin
p30


Nucleic acid sequence

        10         20         30         40         50         60
atgggcaaag gagatcctaa aaagccgaga ggcaaaatgt cctcatatgc attctttgtg
        70         80         90        100        110        120
caaacttgcc gggaggagca caagaagaag cacccggatg cttctgtcaa cttctcagag
       130        140        150        160        170        180
ttctccaaga agtgctcaga gaggtggaag accatgtctg ctaaagaaaa ggggaaattt
       190        200        210        220        230        240
gaagatatgg caaaggctga caaggctcgt tatgaaagag aaatgaaaac ctacatcccc
       250        260        270        280        290        300
cccaaagggg agaccaaaaa gaagttcaag gaccccaatg cacccaagag gcctccttcg
       310        320        330        340        350        360
gccttcttct tgttctgttc tgagtaccgc cccaaaatca aaggcgagca tcctggctta
       370        380        390        400        410        420
tccattggtg atgttgcaaa gaaactagga gagatgtgga acaacactgc agcagatgac
       430        440        450        460        470        480
aagcagccct atgagaagaa agctgccaag ctgaaggaga agtatgagaa ggatattgct
       490        500        510        520        530        540
gcctacagag ctaaaggaaa acctgatgca gcgaaaaagg gggtggtcaa ggctgaaaag
       550        560        570        580        590        600
agcaagaaaa agaaggaaga ggaagatgat gaggaggatg aagaggatga ggaagaggag
       610        620        630        640
gaagaagagg aagacgaaga tgaagaagaa gatgatgatg atgaataa 

Last modification date: Oct. 2, 2011