Homo sapiens L. (human) [HSA]

Amino acids sequence

        10         20         30         40         50         60
MSLWVDKYRP CSLGRLDYHK EQAAQLRNLV QCGDFPHLLV YGPSGAGKKT RIMCILRELY
        70         80         90        100        110        120
GVGVEKLRIE HQTITTPSKK KIEISTIASN YHLEVNPSDA GNSDRVVIQE MLKTVAQSQQ
       130        140        150        160        170        180
LETNSQRDFK VVLLTEVDKL TKDAQHALRR TMEKYMSTCR LILCCNSTSK VIPPIRSRCL
       190        200        210        220        230        240
AVRVPAPSIE DICHVLSTVC KKEGLNLPSQ LAHRLAEKSC RNLRKALLMC EACRVQQYPF
       250        260        270        280        290        300
TADQEIPETD WEVYLRETAN AIVSQQTPQR LLEVRGRLYE LLTHCIPPEI IMKGLLSELL
       310        320        330        340        350
HNCDGQLKGE VAQMAAYYEH RLQLGSKAIY HLEAFVAKFM ALYKKFMEDG LEGMMF

Encoded by RFC3 gene

FULL NAME: replication factor C (activator 1) 3, 38kDa


OTHER NAME(S):
MGC5276
RFC38


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgagcctct gggtggacaa gtatcggccc tgctccttgg gacggctgga ctatcacaag
        70         80         90        100        110        120
gagcaggcgg cccagctgcg gaacctggtg cagtgtggtg actttcctca tctgttagtg
       130        140        150        160        170        180
tacggaccat caggtgctgg aaaaaagaca agaattatgt gtattctacg tgaactttat
       190        200        210        220        230        240
ggtgttggag tggaaaaatt gagaattgaa catcagacca tcacaactcc atctaaaaaa
       250        260        270        280        290        300
aaaattgaaa ttagcaccat tgcaagtaac taccaccttg aagttaatcc tagtgatgct
       310        320        330        340        350        360
ggaaatagtg accgagtagt cattcaggag atgttgaaaa cagtggcaca atcacaacaa
       370        380        390        400        410        420
cttgaaacaa actctcaaag ggattttaaa gtggtattat tgacagaagt tgacaaactc
       430        440        450        460        470        480
accaaagatg ctcagcatgc cttgcgaaga accatggaaa aatatatgtc tacctgcaga
       490        500        510        520        530        540
ttgatcttgt gctgcaattc tacatctaaa gtgatcccac ctattcgtag taggtgcttg
       550        560        570        580        590        600
gcggttcgtg tgcctgctcc cagcattgaa gatatttgcc acgtgttatc tactgtgtgt
       610        620        630        640        650        660
aagaaggaag gtctgaatct tccttcacaa ctggctcata gacttgcaga gaagtcttgt
       670        680        690        700        710        720
agaaatctca gaaaagccct gcttatgtgt gaagcctgca gagtgcaaca atatcctttt
       730        740        750        760        770        780
actgcagatc aagaaatccc tgagacagat tgggaggtgt atctgaggga gactgcaaat
       790        800        810        820        830        840
gctattgtca gtcagcaaac tccacaaagg ctccttgaag ttcgtggaag gctgtatgag
       850        860        870        880        890        900
cttctaactc attgtattcc tcctgagata ataatgaagg gccttctctc agaactgtta
       910        920        930        940        950        960
cataattgtg atggacaact gaaaggggag gtggcacaaa tggcagctta ctatgagcat
       970        980        990       1000       1010       1020
cgtctacagc tgggtagcaa agccatttat cacttggaag cgtttgtggc caaattcatg
      1030       1040       1050       1060       1070
gcactttata agaagttcat ggaggatgga ttggaaggca tgatgttctg a

Last modification date: Oct. 2, 2011