Homo sapiens L. (human) [HSA]

FULL NAME: Replication factor C subunit 4


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.

MISCELLANEOUS:
Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP.


STRUCTURE SIMILARITY:
Belongs to the activator 1 small subunits family.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MQAFLKGTSI STKPPLTKDR GVAASAGSSG ENKKAKPVPW VEKYRPKCVD EVAFQEEVVA
        70         80         90        100        110        120
VLKKSLEGAD LPNLLFYGPP GTGKTSTILA AARELFGPEL FRLRVLELNA SDERGIQVVR
       130        140        150        160        170        180
EKVKNFAQLT VSGSRSDGKP CPPFKIVILD EADSMTSAAQ AALRRTMEKE SKTTRFCLIC
       190        200        210        220        230        240
NYVSRIIEPL TSRCSKFRFK PLSDKIQQQR LLDIAKKENV KISDEGIAYL VKVSEGDLRK
       250        260        270        280        290        300
AITFLQSATR LTGGKEITEK VITDIAGVIP AEKIDGVFAA CQSGSFDKLE AVVKDLIDEG
       310        320        330        340        350        360
HAATQLVNQL HDVVVENNLS DKQKSIITEK LAEVDKCLAD GADEHLQLIS LCATVMQQLS

QNC     

Encoded by RFC4 gene

FULL NAME: replication factor C (activator 1) 4, 37kDa


OTHER NAME(S):
A1
MGC27291
RFC37


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgcaagcat ttcttaaagg tacatccatc agtactaaac ccccgctgac caaggatcga
        70         80         90        100        110        120
ggagtagctg ccagtgcggg aagtagcgga gagaacaaga aagccaaacc cgttccctgg
       130        140        150        160        170        180
gtggaaaaat atcgcccaaa atgtgtggat gaagttgctt tccaggaaga agtggttgca
       190        200        210        220        230        240
gtgctgaaaa aatctttaga aggagcagat cttcctaatc tcttgtttta cggaccacct
       250        260        270        280        290        300
ggaactggaa aaacatccac tattttggca gcagctagag aactctttgg gcctgaactt
       310        320        330        340        350        360
ttccgattaa gagttcttga gttaaatgca tctgatgaac gtggaataca agtagttcga
       370        380        390        400        410        420
gagaaagtga aaaattttgc tcaattaact gtgtcaggaa gtcgctcaga tgggaagccg
       430        440        450        460        470        480
tgtccgcctt ttaagattgt gattctggat gaagcagatt ctatgacctc agctgctcag
       490        500        510        520        530        540
gcagctttaa gacgtaccat ggagaaggag tcgaaaacca cccgattctg tcttatctgt
       550        560        570        580        590        600
aactatgtca gtcgaataat tgaacccctg acctctagat gttcaaaatt ccgcttcaag
       610        620        630        640        650        660
cctctgtcag ataaaattca acagcagcga ttactagaca ttgccaagaa ggaaaatgtc
       670        680        690        700        710        720
aaaattagtg atgagggaat agcttatctt gttaaagtgt cagaaggaga cttaagaaaa
       730        740        750        760        770        780
gccattacat ttcttcaaag cgctactcga ttaacaggtg gaaaggagat cacagagaaa
       790        800        810        820        830        840
gtgattacag acattgccgg ggtaatacca gctgagaaaa ttgatggagt atttgctgcc
       850        860        870        880        890        900
tgtcagagtg gctcttttga caaactagaa gctgtggtca aggatttaat agatgagggt
       910        920        930        940        950        960
catgcagcaa ctcagctcgt caatcaactc catgatgtgg ttgtagaaaa taacttatct
       970        980        990       1000       1010       1020
gataaacaga agtctattat cacagaaaaa cttgccgaag ttgacaaatg cctagcagat
      1030       1040       1050       1060       1070       1080
ggtgctgatg aacatttgca actcatcagc ctttgtgcaa ctgtgatgca gcagttatct
      1090
cagaattgtt aa    

Last modification date: Oct. 2, 2011