Mus musculus L. (mouse) [MMU]

FULL NAME: A/G-specific adenine DNA glycosylase


DESCRIPTION:
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities (By similarity).

STRUCTURE SIMILARITY:
Contains 1 nudix hydrolase domain.
Belongs to the Nth/MutY family.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MKKLQASVRS HKKQPANHKR RRTRALSSSQ AKPSSLDGLA KQKREELLQA SVSPYHLFSD
        70         80         90        100        110        120
VADVTAFRSN LLSWYDQEKR DLPWRNLAKE EANSDRRAYA VWVSEVMLQQ TQVATVIDYY
       130        140        150        160        170        180
TRWMQKWPKL QDLASASLEE VNQLWSGLGY YSRGRRLQEG ARKVVEELGG HMPRTAETLQ
       190        200        210        220        230        240
QLLPGVGRYT AGAIASIAFD QVTGVVDGNV LRVLCRVRAI GADPTSTLVS HHLWNLAQQL
       250        260        270        280        290        300
VDPARPGDFN QAAMELGATV CTPQRPLCSH CPVQSLCRAY QRVQRGQLSA LPGRPDIEEC
       310        320        330        340        350        360
ALNTRQCQLC LTSSSPWDPS MGVANFPRKA SRRPPREEYS ATCVVEQPGA IGGPLVLLVQ
       370        380        390        400        410        420
RPDSGLLAGL WEFPSVTLEP SEQHQHKALL QELQRWCGPL PAIRLQHLGE VIHIFSHIKL
       430        440        450        460        470        480
TYQVYSLALD QAPASTAPPG ARWLTWEEFC NAAVSTAMKK VFRMYEDHRQ GTRKGSKRSQ
       490        500        510
VCPPSSRKKP SLGQQVLDTF FQRHIPTDKP NSTTQ  

Encoded by Mutyh gene

FULL NAME: mutY homolog (E. coli)


OTHER NAME(S):
5730495A01Rik
Mutyha
Mutyhalpha
Mutyhb
Mutyhbeta
Mutyhc
Myh


Nucleic acid sequence

        10         20         30         40         50         60
atgaagaaac tccaagcatc tgtgaggagt cacaaaaagc aaccagccaa ccacaagaga
        70         80         90        100        110        120
aggagaacac gtgcccttag cagcagccag gccaagcctt ccagcctgga tggcctggcc
       130        140        150        160        170        180
aagcagaaga gagaggagtt actgcaggcc tctgtctccc catatcatct cttcagcgac
       190        200        210        220        230        240
gtggccgatg tcacagcttt ccgaagcaac ttgctcagct ggtatgacca agagaagcgt
       250        260        270        280        290        300
gacctccctt ggagaaactt ggcaaaagaa gaggccaact cggacaggag ggcctatgct
       310        320        330        340        350        360
gtgtgggtgt cagaggttat gctgcagcag acccaggttg ccacagtgat cgactattat
       370        380        390        400        410        420
actcgatgga tgcagaagtg gccaaagctt caagacctgg ccagcgcttc cctggaggag
       430        440        450        460        470        480
gtgaaccagc tctggtctgg cctgggctac tattctcgag gccgtcggct acaagaagga
       490        500        510        520        530        540
gctaggaagg tggtagagga gctaggaggc catatgccac gtacagcaga gaccctacag
       550        560        570        580        590        600
cagctcctgc ctggtgtggg gcggtacacg gctggagcca ttgcttccat cgcctttgac
       610        620        630        640        650        660
caggtaaccg gtgtggtgga tgggaacgtt ttacgggtgc tgtgccgtgt ccgggccatt
       670        680        690        700        710        720
ggtgccgatc ccaccagcac ccttgtctct catcacctct ggaacttagc ccagcagctc
       730        740        750        760        770        780
gtggacccag cccggcctgg ggacttcaat caagctgcca tggagctggg ggctacagtg
       790        800        810        820        830        840
tgcaccccac agcgccctct ctgcagccat tgccccgtgc agagtttatg ccgggcatac
       850        860        870        880        890        900
cagagggtgc agcggggtca gctctcagcc ttgccaggcc gtcctgacat agaggagtgt
       910        920        930        940        950        960
gctctcaaca ctagacagtg ccagctttgc ctcacttcct caagcccctg ggaccccagc
       970        980        990       1000       1010       1020
atgggagtgg ccaactttcc tcgaaaggcc agccgcaggc ctcccaggga ggagtactct
      1030       1040       1050       1060       1070       1080
gccacctgtg ttgtggagca gcccggagcc atcgggggtc ccctggtcct cctggtgcaa
      1090       1100       1110       1120       1130       1140
aggcctgact caggtctgct ggcaggactg tgggagttcc catctgtcac cttggagccc
      1150       1160       1170       1180       1190       1200
tcagaacagc atcagcacaa agcccttctg caggaactgc agcgctggtg tgggcccctc
      1210       1220       1230       1240       1250       1260
cctgccattc gtctccagca ccttggggag gttatccaca tcttctctca catcaaactg
      1270       1280       1290       1300       1310       1320
acgtatcaag tatatagtct ggctctagat caagccccag cgagcactgc acctcctggc
      1330       1340       1350       1360       1370       1380
gctcgatggc tgacctggga ggaattctgc aatgcagctg tgtctactgc catgaaaaag
      1390       1400       1410       1420       1430       1440
gtgttccgca tgtatgagga ccatcggcaa gggacccgca agggttcaaa aaggtcccag
      1450       1460       1470       1480       1490       1500
gtgtgtcctc catcaagcag gaaaaaaccc agcctgggac agcaagtcct ggatactttc
      1510       1520       1530       1540
tttcagcgtc atatccccac agacaaaccc aacagtacta cccagtga 

Last modification date: Oct. 2, 2011