Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA damage response protein kinase DUN1


DESCRIPTION:
Transducer of the DNA damage signal. Phosphorylates SML1 on serine residues. Cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.

MISCELLANEOUS:
Present with 3480 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Contains 1 FHA domain.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.


POST-TRANSLATIONAL MODIFICATION:
Autophosphorylation increases in response to DNA damage.


RELATED PATHWAY(S):
DNA damage response (DDR)


Amino acids sequence

        10         20         30         40         50         60
MSLSTKREHS GDVTDSSFKR QQRSNKPSSE YTCLGHLVNL IPGKEQKVEI TNRNVTTIGR
        70         80         90        100        110        120
SRSCDVILSE PDISTFHAEF HLLQMDVDNF QRNLINVIDK SRNGTFINGN RLVKKDYILK
       130        140        150        160        170        180
NGDRIVFGKS CSFLFKYASS SSTDIENDDE KVSSESRSYK NDDEVFKKPQ ISATSSQNAT
       190        200        210        220        230        240
TSAAIRKLNK TRPVSFFDKY LLGKELGAGH YALVKEAKNK KTGQQVAVKI FHAQQNDDQK
       250        260        270        280        290        300
KNKQFREETN ILMRVQHPNI VNLLDSFVEP ISKSQIQKYL VLEKIDDGEL FERIVRKTCL
       310        320        330        340        350        360
RQDESKALFK QLLTGLKYLH EQNIIHRDIK PENILLNITR RENPSQVQLG PWDEDEIDIQ
       370        380        390        400        410        420
VKIADFGLAK FTGEMQFTNT LCGTPSYVAP EVLTKKGYTS KVDLWSAGVI LYVCLCGFPP
       430        440        450        460        470        480
FSDQLGPPSL KEQILQAKYA FYSPYWDKID DSVLHLISNL LVLNPDERYN IDEALNHPWF
       490        500        510
NDIQQQSSVS LELQRLQITD NKIPKTYSEL SCL  

Encoded by DUN1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgagtttgt ccacgaaaag agagcactct ggtgatgtaa ctgactcttc attcaaaaga
        70         80         90        100        110        120
cagcaacgaa gtaataagcc cagctcagaa tacacttgtc tgggccatct ggtgaactta
       130        140        150        160        170        180
atacccggaa aggagcaaaa agtggaaata acaaatagaa acgttactac aatcggtaga
       190        200        210        220        230        240
agtaggtcgt gcgacgttat attgagtgag cctgacatct cgactttcca tgctgagttt
       250        260        270        280        290        300
catctactgc aaatggatgt ggataatttc caaagaaatt tgattaatgt tatcgataag
       310        320        330        340        350        360
agcagaaacg gaacttttat taatggtaat cgtttggtga agaaagacta catccttaag
       370        380        390        400        410        420
aatggtgaca gaattgtctt tggcaaaagt tgctcctttt tgttcaagta cgcatcttca
       430        440        450        460        470        480
tcttctactg acatcgaaaa tgacgatgaa aaggtaagtt cagaaagtcg ttcatataag
       490        500        510        520        530        540
aacgacgacg aagttttcaa gaaaccgcaa ataagtgcta caagtagcca aaatgctaca
       550        560        570        580        590        600
acgagtgccg caattagaaa actgaataag acaaggcctg tgtcgttctt tgataaatat
       610        620        630        640        650        660
ttattaggta aagaattagg tgcagggcac tacgccctgg tgaaagaagc caaaaacaaa
       670        680        690        700        710        720
aaaactggtc agcaagtagc tgtgaaaata ttccacgctc agcaaaatga cgaccaaaaa
       730        740        750        760        770        780
aagaataaac aatttaggga ggaaactaac atcctaatga gagtgcaaca tccaaacatt
       790        800        810        820        830        840
gtcaacttac tagatagttt tgtagagcca atcagcaaat ctcagattca aaaatatttg
       850        860        870        880        890        900
gtactggaaa agatcgacga tggcgaacta tttgaaagaa tcgtcagaaa aacatgtttg
       910        920        930        940        950        960
agacaggatg aatccaaagc tctattcaaa cagttactta ccggattgaa gtatctgcat
       970        980        990       1000       1010       1020
gagcaaaaca tcattcacag agacatcaag ccagaaaata tcttattaaa tataacaagg
      1030       1040       1050       1060       1070       1080
cgcgaaaatc caagtcaagt ccaacttggc ccatgggatg aagatgaaat tgatattcaa
      1090       1100       1110       1120       1130       1140
gttaaaatag cggattttgg cctagcaaaa tttacaggag aaatgcaatt cacaaacaca
      1150       1160       1170       1180       1190       1200
ctttgtggta cgccttctta tgtagcgccc gaagtcctca caaagaaagg atacacatca
      1210       1220       1230       1240       1250       1260
aaagtagatc tttggagtgc tggtgtcata ttatatgtct gtttatgtgg ttttcctcca
      1270       1280       1290       1300       1310       1320
ttcagtgatc aattggggcc accttcattg aaggaacaga tcttacaagc taagtatgcg
      1330       1340       1350       1360       1370       1380
ttttactctc cgtactggga taaaatcgat gactcagtac tacatttaat atccaatctt
      1390       1400       1410       1420       1430       1440
ttggtcctaa atcctgatga aaggtacaat atagatgaag ctttgaacca cccttggttc
      1450       1460       1470       1480       1490       1500
aatgacatac agcaacaaag ctcggtctca ttagaattgc agcgtttaca aattactgac
      1510       1520       1530       1540
aataaaatac ccaaaacata ctcagaatta tcttgcctct aa 

Last modification date: Oct. 2, 2011