Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Serine/threonine-protein kinase chk-1


DESCRIPTION:
Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. May also negatively regulate cell cycle progression during unperturbed cell cycles. Essential for embryogenesis.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.


RELATED PATHWAY(S):
DNA damage response (DDR)


Amino acids sequence

        10         20         30         40         50         60
MSAASTTSTP AAAAVAPQQP ESLYRVVQTL GEGAFGEVLL IVNTKNPEVA AAMKKINIAN
        70         80         90        100        110        120
KSKDFIDNIR KEYLLQKRVS AVGHDNVIRM IGMRNDPQFY YLFLEYADGG ELFDKIEPDC
       130        140        150        160        170        180
GMSPVFAQFY FKQLICGLKF IHDNDVVHRD IKPENLLLTG THVLKISDFG MATLYRNKGE
       190        200        210        220        230        240
ERLLDLSCGT IPYAAPELCA GKKYRGPPVD VWSSGIVLIA MLTGELPWDR ASDASQSYMG
       250        260        270        280        290        300
WISNTSLDER PWKKIDVRAL CMLRKIVTDK TDKRATIEQI QADPWYQHNF GQVETPNGRP
       310        320        330        340        350        360
LKRARNNDEN ITCTQQAECS AKRRHLETPN EKSTLAERQN ASFSQPTKTE DLLLTQHIDM
       370        380        390        400        410        420
SQTNSNLLQR MVCRMTRFCV VTDIRSTYQK VARASEHAGF GVRETDDYRL LVTWREVSMM
       430        440        450        460        470        480
VSLYTMGDIP DKPRVMVDFR RSRGDGIQFK KMFMDVRNRM HEWICTDGNN WLANLGYVPR
       490        500
NPQIVNGGGV NVEHSASSIN VDV   

Encoded by chk-1 gene

FULL NAME: CHeckpoint Kinase


Nucleic acid sequence

        10         20         30         40         50         60
atgtcagcag cgtccacgac ttctacgcca gcagcagcag cagtggcacc tcaacaacca
        70         80         90        100        110        120
gaatcgctgt acagagtcgt tcaaacgctc ggagaaggcg cgttcggcga agtcctcctc
       130        140        150        160        170        180
atcgtcaaca ccaagaatcc agaagtggcg gcggcgatga aaaaaatcaa tatcgccaat
       190        200        210        220        230        240
aaaagcaagg atttcataga caacattcga aaggagtacc ttcttcagaa acgtgtgtcc
       250        260        270        280        290        300
gctgtcggcc atgacaacgt gattcgaatg ataggaatgc gaaatgatcc gcaattttac
       310        320        330        340        350        360
tatctcttcc tggaatatgc ggacggcgga gagcttttcg ataaaataga gcccgattgt
       370        380        390        400        410        420
ggaatgtcgc cggttttcgc gcaattctac ttcaaacaac tcatctgtgg actcaaattt
       430        440        450        460        470        480
attcacgata atgatgtggt tcatcgtgat attaagccgg aaaatttgct gcttaccgga
       490        500        510        520        530        540
actcatgtct taaaaatctc ggatttcggc atggcaactc tttatcggaa caaaggagag
       550        560        570        580        590        600
gagcgactgc tggatttgag ctgtgggacg attccgtacg ctgctccaga gctctgcgcc
       610        620        630        640        650        660
ggaaagaagt accgtgggcc gcccgtcgat gtctggtcgt ctgggattgt gctcattgcg
       670        680        690        700        710        720
atgctcaccg gggagcttcc gtgggatcgg gctagcgacg cctctcaatc ctacatggga
       730        740        750        760        770        780
tggatcagca acacgagcct cgacgagaga ccgtggaaga agatcgacgt tcgagccctc
       790        800        810        820        830        840
tgcatgcttc gtaagatcgt caccgacaag acggacaagc gcgcgacaat cgagcagatc
       850        860        870        880        890        900
caagcggatc cgtggtatca gcacaatttc ggtcaagtcg agacaccgaa cgggcggcca
       910        920        930        940        950        960
ctgaaacgcg ctcgcaacaa tgatgagaat atcacatgca ctcaacaagc cgaatgctcc
       970        980        990       1000       1010       1020
gcgaaacgtc gtcacttgga gactccgaac gagaagagca ctctggcgga gagacagaat
      1030       1040       1050       1060       1070       1080
gcttcgttct cccagccgac aaagactgag gatcttctgc ttactcagca tattgatatg
      1090       1100       1110       1120       1130       1140
tcgcagacca actcgaatct cctccaacga atggtgtgcc gtatgacacg tttctgcgtc
      1150       1160       1170       1180       1190       1200
gtcaccgaca tccgttccac gtaccaaaaa gtggctcgag ccagtgagca cgccggcttc
      1210       1220       1230       1240       1250       1260
ggcgttcgtg agactgacga ctaccgtcta ctagtcacgt ggcgcgaggt ttcgatgatg
      1270       1280       1290       1300       1310       1320
gtcagtctgt acacgatggg cgatattccc gacaagccac gtgtcatggt agatttccgc
      1330       1340       1350       1360       1370       1380
aggtctcgcg gtgacggaat ccagtttaag aagatgttca tggacgttag aaaccgtatg
      1390       1400       1410       1420       1430       1440
catgagtgga tatgtaccga cggaaacaac tggctcgcca atcttggata tgtgccaaga
      1450       1460       1470       1480       1490       1500
aatccgcaga tagttaatgg tggtggagtc aatgtggagc actcggcgtc ctcgatcaat
      1510
gtggatgtct aa    

Last modification date: Oct. 2, 2011