Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: Serine/threonine-protein kinase grp


DESCRIPTION:
Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of CDC2-cyclin complexes and consequent inhibition of cell cycle progression.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated in a MEI-41/ATR dependent manner in response to DNA damage or the presence of unreplicated DNA.


RELATED PATHWAY(S):
DNA damage response (DDR)


Amino acids sequence

        10         20         30         40         50         60
MAATLTEAGT GPAATREFVE GWTLAQTLGE GAYGEVKLLI NRQTGEAVAM KMVDLKKHPD
        70         80         90        100        110        120
AANSVRKEVC IQKMLQDKHI LRFFGKRSQG SVEYIFLEYA AGGELFDRIE PDVGMPQHEA
       130        140        150        160        170        180
QRYFTQLLSG LNYLHQRGIA HRDLKPENLL LDEHDNVKIS DFGMATMFRC KGKERLLDKR
       190        200        210        220        230        240
CGTLPYVAPE VLQKAYHAQP ADLWSCGVIL VTMLAGELPW DQPSTNCTEF TNWRDNDHWQ
       250        260        270        280        290        300
LQTPWSKLDT LAISLLRKLL ATSPGTRLTL EKTLDHKWCN MQFADNERSY DLVDSAAALE
       310        320        330        340        350        360
ICSPKAKRQR LQSSAHLSNG LDDSISRNYC SQPMPTMRSD DDFNVRLGSG RSKEDGGDRQ
       370        380        390        400        410        420
TLAQEARLSY SFSQPALLDD LLLATQMNQT QNASQNYFQR LVRRMTRFFV TTRWDDTIKR
       430        440        450        460        470        480
LVGTIERLGG YTCKFGDDGV VTVSTVDRNK LRLVFKAHII EMDGKILVDC RLSKGCGLEF
       490        500        510
KRRFIKIKNA LEDIVLKGPT TWPIAIATNS VP  

Encoded by grp gene

FULL NAME: grapes


OTHER NAME(S):
1C
CG17161
chk1
Chk1
CHK1
CHK1/Grapes
dChk1
DmChk1
Dmel\CG17161
Grp
grp(chk)
Grp/DChk1
grps
l(2)k15102
lemp
Pk36A
Pk?1


Nucleic acid sequence

        10         20         30         40         50         60
atggctgcaa cgctgacgga agcgggaaca ggtcctgcgg ccaccaggga gttcgtcgag
        70         80         90        100        110        120
ggatggactt tggcccaaac tctgggcgaa ggtgcctacg gcgaggtaaa gctactaatc
       130        140        150        160        170        180
aaccggcaga ctggcgaggc tgtggccatg aaaatggtgg atctaaaaaa acatccggat
       190        200        210        220        230        240
gcagcgaact cggtgcgaaa ggaggtatgc atacagaaga tgctccagga taagcatatc
       250        260        270        280        290        300
ctccgatttt tcggcaaacg ttcgcaaggc agtgtggagt acatattcct ggaatacgcc
       310        320        330        340        350        360
gccggcggag agctattcga tcgaatagaa ccagacgtgg gaatgccgca gcatgaggct
       370        380        390        400        410        420
caaaggtatt ttacacagct cctgtccgga ctcaattacc tgcatcagcg tgggatcgct
       430        440        450        460        470        480
catcgggatc tgaagccgga aaatctgctg cttgacgagc atgacaacgt gaaaatatcg
       490        500        510        520        530        540
gactttggca tggctactat gtttaggtgc aagggcaagg agcgactgct ggacaaacgc
       550        560        570        580        590        600
tgcggcacct tgccgtatgt ggcgcccgag gtgctacaga aggcatatca cgcccagccg
       610        620        630        640        650        660
gcggatctct ggtcgtgtgg cgttatattg gtgacaatgc tggcgggtga gctgccctgg
       670        680        690        700        710        720
gatcagccgt ccaccaattg cacggagttc accaactgga gggataacga tcactggcaa
       730        740        750        760        770        780
ctgcagactc cttggagcaa actggacacc ttggctattt cgctgcttcg caagctgctg
       790        800        810        820        830        840
gccaccagtc ctggcacgcg tttgaccctg gagaaaaccc tggatcacaa atggtgcaac
       850        860        870        880        890        900
atgcagtttg cagacaatga acgttcctat gacctggtgg actcggcggc tgccctggag
       910        920        930        940        950        960
atatgctcgc caaaggctaa gaggcagcgt ctgcagtcta gtgcccactt gagcaatggc
       970        980        990       1000       1010       1020
ctggatgact ccatctcccg gaactactgc tctcaaccca tgcccacaat gcgcagcgac
      1030       1040       1050       1060       1070       1080
gatgacttca atgtcagact gggcagtggc cgatccaagg aggatggagg cgaccgccag
      1090       1100       1110       1120       1130       1140
acgttggccc aggaggctcg gctcagttac tccttctcgc aaccagcttt gcttgatgat
      1150       1160       1170       1180       1190       1200
ctcctactgg ctacccagat gaaccaaacg cagaacgctt cccagaacta tttccagcgt
      1210       1220       1230       1240       1250       1260
ttggtgagga gaatgacccg attctttgtg accacacgat gggatgacac tatcaagcga
      1270       1280       1290       1300       1310       1320
ttggtgggaa ccatcgaaag actgggtggt tatacgtgca aatttggtga cgacggagtg
      1330       1340       1350       1360       1370       1380
gtcaccgtat ccacagtcga tcggaataag ctgcgattgg ttttcaaggc acacattata
      1390       1400       1410       1420       1430       1440
gagatggatg gcaagattct tgttgactgc cggctgtcaa agggttgcgg cttggagttt
      1450       1460       1470       1480       1490       1500
aaacgacgat ttatcaagat caaaaacgcc ctggaggata tcgtgcttaa aggacccacc
      1510       1520       1530
acctggccga ttgcgattgc tacaaattcg gtgccttag  

Last modification date: Oct. 2, 2011