Homo sapiens L. (human) [HSA]

FULL NAME: Replication factor C subunit 2


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).

STRUCTURE SIMILARITY:
Belongs to the activator 1 small subunits family.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MEVEAVCGGA GEVEAQDSDP APAFSKAPGS AGHYELPWVE KYRPVKLNEI VGNEDTVSRL
        70         80         90        100        110        120
EVFAREGNVP NIIIAGPPGT GKTTSILCLA RALLGPALKD AMLELNASND SMTDGAQQAL
       130        140        150        160        170        180
RRTMEIYSKT TRFALACNAS DKIIEPIQSR CAVLRYTKLT DAQILTRLMN VIEKERVPYT
       190        200        210        220        230        240
DDGLEAIIFT AQGDMRQALN NLQSTFSGFG FINSENVFKV CDEPHPLLVK EMIQHCVNAN
       250        260        270        280        290        300
IDEAYKILAH LWHLGYSPED IIGNIFRVCK TFQMAEYLKL EFIKEIGYTH MKIAEGVNSL
       310        320
LQMAGLLARL CQKTMAPVAS    

Encoded by RFC2 gene

FULL NAME: replication factor C (activator 1) 2, 40kDa


OTHER NAME(S):
A1
MGC3665
RFC40


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggaggtgg aggccgtctg tggtggcgcg ggcgaggtgg aggcccagga ctctgaccct
        70         80         90        100        110        120
gcccctgcct tcagcaaggc ccccggcagc gccggccact acgaactgcc gtgggttgaa
       130        140        150        160        170        180
aaatataggc cagtaaagct gaatgaaatt gtcgggaatg aagacaccgt gagcaggcta
       190        200        210        220        230        240
gaggtctttg caagggaagg aaatgtgccc aacatcatca ttgcgggccc tccaggaacc
       250        260        270        280        290        300
ggcaagacca caagcattct gtgcttggcc cgggccctgc tgggcccagc actcaaagat
       310        320        330        340        350        360
gccatgttgg aactcaatgc ttcaaatgac agcatgaccg acggagccca gcaagccttg
       370        380        390        400        410        420
aggagaacca tggaaatcta ctctaaaacc actcgcttcg cccttgcttg taatgcttcg
       430        440        450        460        470        480
gataagatca tcgagcccat tcagtcccgc tgtgcagtcc tccggtacac aaagctgacc
       490        500        510        520        530        540
gacgcccaga tcctcaccag gctgatgaat gttatcgaga aggagagggt accctacact
       550        560        570        580        590        600
gatgacggcc tagaagccat catcttcacg gcccagggag acatgaggca ggcgctgaac
       610        620        630        640        650        660
aacctgcagt ccaccttctc aggatttggc ttcattaaca gtgagaacgt gttcaaggtc
       670        680        690        700        710        720
tgtgacgagc cccacccact gctggtaaag gagatgatcc agcactgtgt gaatgccaac
       730        740        750        760        770        780
attgacgaag cctacaagat tcttgctcac ttgtggcatc tgggctactc accagaagat
       790        800        810        820        830        840
atcattggca acatctttcg agtgtgtaaa actttccaaa tggcagaata cctgaaactg
       850        860        870        880        890        900
gagtttatca aggaaattgg atacactcac atgaaaatag cggaaggagt gaactctctt
       910        920        930        940        950        960
ttgcagatgg caggcctcct ggcaaggctg tgtcagaaga caatggcccc ggtggccagt

tag     

Last modification date: Oct. 2, 2011