Homo sapiens L. (human) [HSA]

FULL NAME: Structure-specific endonuclease subunit SLX1


DESCRIPTION:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.

STRUCTURE SIMILARITY:
Contains 1 SLX1-type zinc finger.
Belongs to the SLX1 family.
Contains 1 GIY-YIG domain.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


RELATED DAMAGE:
intErstrand crosslinks (ICLs)


Amino acids sequence

        10         20         30         40         50         60
MGPAGVAARP GRFFGVYLLY CLNPRYRGRV YVGFTVNTAR RVQQHNGGRK KGGAWRTSGR
        70         80         90        100        110        120
GPWEMVLVVH GFPSSVAALR FEWAWQHPHA SRRLAHVGPR LRGETAFAFH LRVLAHMLRA
       130        140        150        160        170        180
PPWARLPLTL RWVRPDLRQD LCLPPPPHVP LAFGPPPPQA PAPRRRAGPF DDAEPEPDQG
       190        200        210        220        230        240
DPGACCSLCA QTIQDEEGPL CCPHPGCLLR AHVICLAEEF LQEEPGQLLP LEGQCPCCEK
       250        260        270
SLLWGDLIWL CQMDTEKEVE DSELEEAHWT DLLET  

Encoded by SLX1A gene

FULL NAME: SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)


OTHER NAME(S):
GIYD1
GIYD2
SLX1B


DESCRIPTION:
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atgggtcccg cgggggtcgc ggcgaggcca gggcgctttt tcggcgtcta cctgctctac
        70         80         90        100        110        120
tgcctgaacc cccggtaccg gggccgcgtc tacgtggggt tcactgtcaa cactgctcgt
       130        140        150        160        170        180
cgggtccagc agcacaatgg gggccgcaaa aaaggcgggg cctggcggac cagcgggcga
       190        200        210        220        230        240
gggccctggg agatggtgct cgtcgtgcac ggcttcccgt cctccgtggc cgcccttcgg
       250        260        270        280        290        300
tttgagtggg cttggcagca cccgcacgcc tcgcgccgcc tggcgcacgt ggggcctcgc
       310        320        330        340        350        360
ctgcgaggag agacagcctt cgctttccac ctgcgcgtgc tggcgcacat gctgcgcgca
       370        380        390        400        410        420
ccgccctggg ctcgcctccc gctcacgctg cgctgggtgc gcccagacct ccgccaggac
       430        440        450        460        470        480
ctctgcctcc cgccgccgcc gcacgtgcct ctggccttcg ggcctccacc gccccaggcc
       490        500        510        520        530        540
ccggccccaa ggcgccgcgc aggtcccttt gatgacgcgg agcctgagcc agaccagggg
       550        560        570        580        590        600
gatccagggg cctgctgctc cctgtgcgcc cagaccatcc aggatgaaga ggggcccttg
       610        620        630        640        650        660
tgttgccccc accctggctg cctgctaagg gcccatgtga tctgcctggc agaggagttt
       670        680        690        700        710        720
cttcaggaag aaccagggca gcttctgccc ctagagggcc aatgcccttg ctgtgagaag
       730        740        750        760        770        780
tcactgcttt ggggagacct gatctggctg tgccagatgg acactgagaa agaagtagaa
       790        800        810        820
gactcagaat tagaagaggc acactggaca gacctgctgg agacctga 

Last modification date: Oct. 2, 2011