Mus musculus L. (mouse) [MMU]

FULL NAME: N-glycosylase/DNA lyase


DESCRIPTION:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

STRUCTURE SIMILARITY:
Belongs to the type-1 OGG1 family.


CATALYTIC ACTIVITY:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MLFRSWLPSS MRHRTLSSSP ALWASIPCPR SELRLDLVLA SGQSFRWKEQ SPAHWSGVLA
        70         80         90        100        110        120
DQVWTLTQTE DQLYCTVYRG DDSQVSRPTL EELETLHKYF QLDVSLAQLY SHWASVDSHF
       130        140        150        160        170        180
QRVAQKFQGV RLLRQDPTEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG
       190        200        210        220        230        240
FPNLHALAGP EAETHLRKLG LGYRARYVRA SAKAILEEQG GPAWLQQLRV APYEEAHKAL
       250        260        270        280        290        300
CTLPGVGAKV ADCICLMALD KPQAVPVDVH VWQIAHRDYG WHPKTSQAKG PSPLANKELG
       310        320        330        340
NFFRNLWGPY AGWAQAVLFS ADLRQPSLSR EPPAKRKKGS KRPEG 

Encoded by Ogg1 gene

FULL NAME: 8-oxoguanine DNA-glycosylase 1


OTHER NAME(S):
Mmh


Nucleic acid sequence

        10         20         30         40         50         60
atgttattcc gttcctggct gcctagcagc atgagacatc gcaccctaag ctccagcccg
        70         80         90        100        110        120
gccctctggg cctctatccc gtgtccacgc tctgagctgc gtctggactt ggttttagct
       130        140        150        160        170        180
tctggacagt ccttccggtg gaaggagcag agccctgctc actggagtgg cgtgctggca
       190        200        210        220        230        240
gatcaagtat ggacactgac tcagacggag gaccagctct attgcactgt gtaccgagga
       250        260        270        280        290        300
gacgacagcc aggtcagcag gcccacccta gaggagctgg aaaccctaca caagtacttt
       310        320        330        340        350        360
cagctagatg tcagcctggc acagctgtat agccactggg cttctgtaga ctcccacttc
       370        380        390        400        410        420
caaagagtgg cccagaaatt ccaaggtgtg agactgctga gacaagaccc cactgagtgc
       430        440        450        460        470        480
cttttctctt tcatctgttc ctccaacaac aacattgctc gcattactgg catggtggaa
       490        500        510        520        530        540
cggctctgcc aggcctttgg acctcgactc attcagcttg atgatgtcac ttatcatggc
       550        560        570        580        590        600
ttcccaaacc tccatgccct ggctggtcca gaagcagaga ctcacctgag gaagttgggc
       610        620        630        640        650        660
ctggggtacc gtgcccgcta tgtacgtgcc agtgccaaag ccatcctcga agagcaaggt
       670        680        690        700        710        720
gggccagctt ggctgcagca gcttcgagtg gccccttatg aagaggccca caaggccctc
       730        740        750        760        770        780
tgcaccctgc ccggggtggg cgccaaggtg gctgactgca tctgcttaat ggcccttgac
       790        800        810        820        830        840
aaaccccagg ctgtgcccgt ggatgtccat gtatggcaga ttgcccatcg tgactacggc
       850        860        870        880        890        900
tggcatccta agacatccca ggctaagggc ccgagccctt tggccaacaa agaactggga
       910        920        930        940        950        960
aactttttcc ggaatctgtg gggaccttat gctggctggg cccaagcagt gctgttcagt
       970        980        990       1000       1010       1020
gctgaccttc gccaaccaag cctgtctcgg gagccaccag caaagcgcaa aaagggatct
      1030
aagaggccag agggctag    

Last modification date: Oct. 2, 2011